A5029849389- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Advancements in Transdermal Drug Delivery
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Hydrogels: synthesis, properties, applications
- Natural Compounds in Disease Treatment
- 3D Printing in Biomedical Research
- Luminescence and Fluorescent Materials
- Cancer Research and Treatments
- Immune cells in cancer
- Drug Solubulity and Delivery Systems
- Innovative Microfluidic and Catalytic Techniques Innovation
- Gold and Silver Nanoparticles Synthesis and Applications
- Immunotherapy and Immune Responses
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
- Nanocluster Synthesis and Applications
- Dendrimers and Hyperbranched Polymers
Huazhong University of Science and Technology
2016-2025
National Engineering Research Center for Nanotechnology
2011-2025
Xinjiang Institute of Materia Medica
2018-2025
Zhejiang Shuren University
2025
South China University of Technology
2025
Wuhan National Laboratory for Optoelectronics
2025
Central Hospital of Wuhan
2025
Tongji Hospital
2015-2024
Sinovac Biotech
2024
First Affiliated Hospital of Fujian Medical University
2023
Developing biomimetic nanoparticles without loss of the integrity proteins remains a major challenge in cancer chemotherapy. Here, we develop biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon (PSiNPs) as drug carrier for targeted Exosome-sheathed doxorubicin-loaded PSiNPs (DOX@E-PSiNPs), generated by exocytosis endocytosed DOX-loaded from tumor cells, exhibit enhanced accumulation, extravasation blood vessels and penetration into deep parenchyma following intravenous...
One of the main challenges for immune checkpoint blockade antibodies lies in malignancies with limited T-cell responses or immunologically "cold" tumors. Inspired by capability fever-like heat inducing an immune-favorable tumor microenvironment, mild photothermal therapy (PTT) is proposed to sensitize tumors inhibition and turn "hot." Here we present a combined all-in-one all-in-control strategy realize local symbiotic photothermal-assisted immunotherapy (SMPAI). We load both near-infrared...
Abstract The ultrahigh concentration of glutathione (GSH) inside tumors destroys reactive oxygen species (ROS)‐based therapy, improving the outcome chemodynamic therapy (CDT)‐enhanced sonodynamic (SDT) by depleting GSH is full great challenge. Herein, PtCu 3 nanocages are first reported as acting a sonosensitizer with highly efficient ROS generation under ultrasound irradiation. In addition, can act horseradish peroxidase‐like nanozymes, catalyzing decomposition H 2 O into • OH acidic...
Ag2S nanoparticles are increasingly important in biomedicine, such as cancer imaging. However, there has been only limited success the exploration of theranostic for photoinduced imaging and simultaneous therapy. Here we report size-dependent nanodots (NDs) with well-defined nanostructure a agent multimodal photothermal The NDs precisely synthesized through carefully controlled growth hollow human serum albumin nanocages. These produce effective fluorescence second near-infrared (NIR-II)...
Abstract The main challenges for programmed cell death 1(PD-1)/PD-1 ligand (PD-L1) checkpoint blockade lie in a lack of sufficient T infiltration, tumor immunosuppressive microenvironment, and the inadequate accumulation penetration anti-PD-1/PD-L1 antibody. Resetting tumor-associated macrophages (TAMs) is promising strategy to enhance T-cell antitumor immunity ameliorate immunosuppression. Here, mannose-modified macrophage-derived microparticles (Man-MPs) loading metformin (Met@Man-MPs) are...
The acquisition of multidrug resistance (MDR) is a major hurdle for the successful chemotherapy tumors. Herein, novel hybrid micelle with pH and near‐infrared (NIR) light dual‐responsive property reported reversing doxorubicin (DOX) in breast cancer. micelles are designed to integrate pH‐ NIR light‐responsive an amphiphilic diblock polymer high DOX loading capacity polymeric prodrug into one single nanocomposite. At physiological condition (i.e., 7.4), form compact nanostructure particle...
Development of efficient therapeutic strategy to incorporate ultrasound (US)-triggered sonodynamic therapy (SDT) and ferroptosis is highly promising in cancer therapy. However, the SDT efficacy severely limited by hypoxia high glutathione (GSH) tumor microenvironment, associated with reactive oxygen species (ROS) GSH depletion. Methods: A manganese porphyrin-based metal-organic framework (Mn-MOF) was constructed as a nanosensitizer self-supply (O2) decrease for enhanced ferroptosis. In vitro...
Abstract Despite the promise of sonodynamic processes in cancer therapy, existing sonosensitizers often fail to regulate generation reactive oxygen species (ROS) against tumors, potentially leading off‐target toxicity normal tissues. We report a transformable core‐shell nanosonosensitizer (TiO 2 @CaP) that reinvigorates ROS and dissolves its CaP shell release Ca 2+ an acidic tumor microenvironment (TME) under ultrasound activation. Thus, TiO @CaP acts as smart specifically induces...
Cost-effective adsorbents for water treatment is easy available through one-pot Friedel–Crafts reaction of triptycene. With hierarchical porous structure, high surface area, thermal stability, and excellent adsorption capacities organic solvents dyes, the triptycene-based hyper-cross-linked polymer sponge (THPS) may be ideal a wide range large-scale applications in purification treatment.
Transition metal sulfide nanocrystals are developed as a theranostic platform through the protein-nanoreactor approach with facile functionalization for multimodal NIRF/PA/SPECT/CT imaging and photothermal tumor ablation. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials peer reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should...
Abstract Insufficient tumor accumulation and distribution of photosensitizers as well low antitumor immunity severely restrict the therapeutic efficacy photothermal therapy (PTT). Cancer-associated fibroblasts (CAFs) play a key role in extracellular matrix (ECM) remodeling immune evasion. Reshaping microenvironment via CAF regulation might provide potential approach for complete elimination combination with PTT. Here, cell-derived microparticles co-delivering calcipotriol Indocyanine green...
Elemental tellurium (Te) nanoparticles are increasingly important in a variety of applications such as thermoelectricity, photoconductivity, and piezoelectricity. However, they have been explored with limited success their biomedical use, thus tremendous challenge still exists the exploration Te that can treat tumors an effective anticancer agent. Here, we introduce bifunctional nanodots well-defined nanostructure agent for photo-induced synergistic cancer therapy tumor ablation, which is...