A5063318421- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Medical Imaging Techniques and Applications
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Cholesterol and Lipid Metabolism
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Immune cells in cancer
- Advanced Glycation End Products research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Asthma and respiratory diseases
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects of Natural Compounds
- MRI in cancer diagnosis
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Prostate Cancer Treatment and Research
Chinese Academy of Sciences
2012-2025
University of Chinese Academy of Sciences
2025
Institute of Atmospheric Physics
2025
Army Medical University
2013-2024
Quzhou University
2024
Shanghai University of Medicine and Health Sciences
2022-2024
Renji Hospital
2008-2024
Shanghai Jiao Tong University
2008-2024
University of Shanghai for Science and Technology
2022-2024
Jiading District Central Hospital
2022-2024
Abstract Background High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate mechanism by which hypoxia promotes HCC through inducing epithelial-mesenchymal transition (EMT). Methods The expression EMT markers was analyzed immunohistochemistry. Effect on induction ability cell migration were...
Abstract The main challenges for programmed cell death 1(PD-1)/PD-1 ligand (PD-L1) checkpoint blockade lie in a lack of sufficient T infiltration, tumor immunosuppressive microenvironment, and the inadequate accumulation penetration anti-PD-1/PD-L1 antibody. Resetting tumor-associated macrophages (TAMs) is promising strategy to enhance T-cell antitumor immunity ameliorate immunosuppression. Here, mannose-modified macrophage-derived microparticles (Man-MPs) loading metformin (Met@Man-MPs) are...
Abstract The farnesoid X receptor (FXR) is a member of the nuclear superfamily that highly expressed in liver, kidney, adrenal gland, and intestine. It plays an important role regulating progression several cancers including hepatocellular carcinoma (HCC). So it necessary to study regulation FXR. In this study, we found expression miR-421 was inversely correlated with FXR protein level HCC cell lines. Treatment mimic repressed translation. reporter assay revealed targeted 3′ untranslated...
CD274, one of two co-stimulatory ligands for programmed death 1 and widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells regulates inflammatory responses. However, changes CD274 gene expression underlying molecular mechanism are poorly understood during Therefore, delineation complex mechanisms regulating is critical to understand this immunoregulatory The purpose study was assess an vitro monocyte model response. Firstly, levels human primary monocytes after...
The noninflamed microenvironment in prostate cancer represents a barrier to immunotherapy. Genetic alterations underlying cell-intrinsic oncogenic signaling are increasingly appreciated for their role shaping the immune landscape. Recently, we identified Pygopus 2 (
Recent studies show that thymic stromal lymphopoietin (TSLP) plays a critical role in the upstream phase of allergic cascade to induce T helper type 2 cell (Th2)-dominant diseases. However, effect blocking TSLP signalling with soluble receptor (TSLPR), TSLPR-immunoglobulin (Ig), on asthma development needs further investigation. Here, we examined effects TSLPR-Ig asthmatic airway inflammation and dendritic (DC) function. (comprising extracellular domain murine TSLPR an IgG2a Fc tail)...
microRNA-122 (miR-122) is the most abundant and specific miRNA in liver. It acts as an important tumor suppressor hepatocellular carcinoma (HCC) through regulating its target genes, but details of own regulation are largely unknown. Farnesoid X receptor (FXR), a transcription factor with multiple functions, plays role protecting against liver carcinogenesis, it unclear whether anti-HCC effect FXR involved miR-122. The levels miR-122 HCC tissues cell lines were examined by quantitative...
Receptor for advanced glycation end products (RAGE) plays a role in inflammatory reactions. The soluble form of RAGE (sRAGE) acts as decoy to inhibit interactions with such High mobility group box 1 (HMGB1). We have demonstrated that HMGB1 directs Th17 skewing by regulating dendritic cell (DC) functions previous study. However, the protective effects blockade sRAGE development neutrophilic asthma remain unclear. Here, we showed allergen challenge decreased expression murine model asthma,...
The Warburg effect describes the increased reliance of tumor cells on glycolysis for ATP generation. Mitochondrial respiratory defect is thought to be an important factor leading in some types cells. Consequently, there growing interest developing anti-cancer drugs that target mitochondria. One example dichloroacetate (DCA) stimulates mitochondria through inhibition pyruvate dehydrogenase kinase. We investigated activity DCA using biochemical and isotopic tracing methods. observed...
Abstract Melatonin has been previously shown to prevent nonalcoholic fatty liver disease (NAFLD), yet the underlying mechanisms are poorly understood. Here, we identified a unknown regulatory action of melatonin on apoptosis signal‐regulating kinase 1 (ASK1) signaling pathway in pathogenesis and development NAFLD. Although administration did not alter food intake, it significantly alleviated phenotypes, including body weight gain, insulin resistance, hepatic lipid accumulation,...
// Fei Guo 1, * , Zhizhen Xu 2, Yan Zhang 2 Peng Jiang 1 Gang Huang Shan Chen Xilin Lyu Ping Zheng Xin Zhao Yijun Zeng Shuguang Wang Fengtian He Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing 400038, China Biochemistry and Molecular Biology, College Basic Sciences, These authors have contributed equally to this work Correspondence to: He, e-mail: hefengtian06@aliyun.com Wang, sgwang90@aliyun.com Keywords: HCC, FXR, SOCS3, STAT3...
Abstract Background MicroRNAs (miRNAs) emerge as new important regulators of lipid homeostasis by regulating corresponding genes. MiR-613 is a newly discovered microRNA, which the biological function unknown. A recent report has shown that miR-613 downregulates liver X receptor α (LXRα), ligand-activated nuclear playing an role in regulation metabolism. The purpose this study to explore effect and molecular basis on lipogenesis HepG2 cells. Methods cells were transiently transfected with...
We demonstrate that high mobility group box 1 protein (HMGB1) directs Th17 skewing by regulating dendritic cell (DC) function. First, our in vitro studies reveal recombinant HMGB1 (rHMGB1) activates myeloid DCs to produce IL-23 , and rHMGB1-activated prime naïve lymphocytes the cytokine IL-17A. Second, we anti-HMGB1 neutralizing antibody attenuates expression, neutrophilic inflammation, airway hyperresponsiveness, Th17-related secretion vivo using a murine model of asthma induced ovalbumin...