A5080747136- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- RNA regulation and disease
- Birth, Development, and Health
- Antioxidant Activity and Oxidative Stress
- Atherosclerosis and Cardiovascular Diseases
- Sodium Intake and Health
- Pregnancy and preeclampsia studies
- Single-cell and spatial transcriptomics
- Muscle Physiology and Disorders
- Signaling Pathways in Disease
- Cardiac Valve Diseases and Treatments
- Extracellular vesicles in disease
- Sirtuins and Resveratrol in Medicine
- Antimicrobial Resistance in Staphylococcus
- Chronic Kidney Disease and Diabetes
- Adipose Tissue and Metabolism
- Down syndrome and intellectual disability research
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Cardiac Ischemia and Reperfusion
- Lipid metabolism and disorders
Army Medical University
2015-2025
Daping Hospital
2015-2025
Boston Children's Hospital
2013-2024
Harvard University
2013-2024
Tibet University
2024
Boston University
2024
Ministry of Education of the People's Republic of China
2023
Harvard Stem Cell Institute
2014
Dana-Farber Cancer Institute
2014
Long noncoding RNAs (lncRNAs) have recently been implicated in many biological processes and diseases. Atherosclerosis is a major risk factor for cardiovascular disease. However, the functional role of lncRNAs atherosclerosis largely unknown.We identified lincRNA-p21 as key regulator cell proliferation apoptosis during atherosclerosis. The expression was dramatically downregulated atherosclerotic plaques ApoE(-/-) mice, an animal model Through loss- gain-of-function approaches, we showed...
Long non-coding RNAs (lncRNAs) have been reported to be involved in the pathogenesis of cardiovascular disease (CVD), but whether circulating lncRNAs can serve as a coronary artery (CAD), biomarker is not known. The present study screened by microarray analysis plasma from CAD patients and control individuals found that 265 were differentially expressed. To find specific possible candidates, we used following criteria for 174 up-regulated lncRNAs: signal intensity ≥8, fold change >2.5...
Heart failure (HF) is among the leading causes of morbidity and mortality, its prevalence continues to rise. LARP7 (La ribonucleoprotein domain family member 7) a master regulator that governs DNA damage response RNAPII (RNA polymerase II) pausing pathway, but role in HF pathogenesis incompletely understood. We assessed expression human nonhuman primate mouse models. To study function heart, we generated global cardiac-specific knockout mice. acutely abolished mature cardiomyocytes by...
Circular RNAs (circRNAs) have been recently recognized as playing a role in the pathogenesis of vascular remodeling–related diseases by modulating functions miRNAs. However, interplay between circRNAs and proteins during remodeling remains poorly understood. Here, we investigated previously identified circRNA, circEsyt2, whose expression is known to be upregulated remodeling. Loss- gain-of‑function mutation analyses smooth muscle cells (VSMCs) revealed that circEsyt2 enhanced cell...
Cellular senescence is associated with pleiotropic physiopathological processes, including aging and age-related diseases. The persistent DNA damage a major stress leading to senescence, but the underlying molecular link remains elusive. Here, we identify La Ribonucleoprotein 7 (LARP7), 7SK RNA binding protein, as an antagonist. damage-mediated Ataxia Telangiectasia Mutated (ATM) activation triggers extracellular shuttling downregulation of LARP7, which dampens SIRT1 deacetylase activity,...
BackgroundWhile the adult mammalian heart undergoes only modest renewal through cardiomyocyte proliferation, boosting this process is considered a promising therapeutic strategy to repair cardiac injury. This study explored role and mechanism of dual-specificity tyrosine regulated kinase 1A (DYRK1A) in regulating cell cycle activation after myocardial infarction (MI).MethodsDYRK1A-knockout mice DYRK1A inhibitors were used investigate following MI. Additionally, we underlying mechanisms by...
Our previous study showed that besides mRNAs and microRNAs, there are DNA fragments within extracellular vesicles (EVs). The BCR/ABL hybrid gene, involved in the pathogenesis of chronic myeloid leukemia (CML), could be transferred from K562 EVs to neutrophils decrease their phagocytic activity vitro. present provides evidence DNAs have pathophysiological significance vivo. Two months after injection into tail vein Sprague-Dawley (SD) rats, they some characteristics CML, e.g., feeble,...
Ischemic cardiomyopathy (ICM) resulting from myocardial infarction is a major cause of heart failure (HF). Recently, thousands long non-coding RNAs (lncRNAs) have been discovered and implicated in variety biological processes. However, the role most lncRNAs HF remains largely unknown. The aim this study to test hypothesis that expression function are differentially regulated diseased hearts. In study, we performed RNA deep sequencing protein-coding cardiac samples patients with ICM ( n = 15)...
Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to proliferative is a pathological hallmark in various cardiovascular diseases. Recently, subset of long noncoding RNAs was identified produce functional polypeptides. However, the impact and regulatory mechanisms VSMCs switching remain be fully elucidated.
Adverse environmental exposure during the prenatal period can lead to diseases in offspring, including hypertension. Whether or not hypertensive phenotype be transgenerationally transmitted is known.Pregnant Sprague Dawley rats were intraperitoneally injected with lipopolysaccharide (LPS) on gestation days 6, 8, 10, and 12 generate LPS model. Blood pressure was monitored by both telemetry tail-cuff method. RNA sequencing performed analyze transcriptome alteration kidney of third generation....
Aims: Smooth muscle cell (SMC) remodeling poses a critical feature in the development and progression of atherosclerosis.Although fate mapping silicon approaches have expanded SMC phenotypes atherosclerosis, it still remains elusive about contributions individual molecular dynamics to advanced atherosclerotic plaque.Methods: Using single-cell transcriptome, we investigated cellular compositions human carotid plaque laden with core, followed by vivo experiments utilizing SMC-lineage tracing...
Long noncoding RNA (lncRNA) can regulate various physiological and pathological processes through multiple molecular mechanisms in cis trans. However, the role of lncRNAs cardiac hypertrophy is yet to be fully elucidated. A mouse lncRNA microarray was used identify differentially expressed hearts following transverse aortic constriction-induced pressure overload comparing sham-operated samples. The direct impact one lncRNA, Ahit, on cardiomyocyte characterized neonatal rat cardiomyocytes...
Abstract Background MicroRNAs (miRNAs) emerge as new important regulators of lipid homeostasis by regulating corresponding genes. MiR-613 is a newly discovered microRNA, which the biological function unknown. A recent report has shown that miR-613 downregulates liver X receptor α (LXRα), ligand-activated nuclear playing an role in regulation metabolism. The purpose this study to explore effect and molecular basis on lipogenesis HepG2 cells. Methods cells were transiently transfected with...
Cardiomyopathy is a common human disorder that characterized by contractile dysfunction and cardiac remodeling. Genetic mutations altered expression of genes encoding many signaling molecules proteins are associated with cardiomyopathy; however, how cardiomyocytes sense pathophysiological stresses in order to then modulate remodeling remains poorly understood. Here, we have described regulator the heart harmonizes progression hypertrophy dilation. We determined myocyte-enriched protein...
The colony-forming ability of cervical cancer is affected by many factors. Oct4, an important transcription factor, highly expressed in several tumors and promotes the cells. Thus, it considered a potential target for treatment cancer. However, we know little about expression level Oct4 its epigenetic regulatory mechanism In this study, are first to observe that human papillomavirus (HPV)-positive cell lines (HeLa, Caski) have stronger than HPV-negative (C-33A). Moreover, both HeLa Caski...
One of the features pathological cardiac hypertrophy is enhanced translation and protein synthesis. Translational inhibition has been shown to be an effective means treating hypertrophy, although system-wide side effects are common. Regulators translation, such as cardiac-specific long non-coding RNAs (lncRNAs), could provide new, more targeted, therapeutic approaches inhibit hypertrophy. Therefore, we generated mice lacking a previously identified lncRNA named CARDINAL examine its function....
The aim of this study was to evaluate the prevalence vitamin D deficiency in chronic renal failure (CRF) patients on peritoneal dialysis (PD) and correlate findings with various demographic osteodystrophy markers.This cross-sectional, multicenter carried out 273 PD a mean age 61.7 +/- 10.9 years duration 3.3 2.2 years. It included 123 female 150 male from 20 centers Greece Turkey, countries that are same latitude, namely, 36-42 degrees north. We measured 25(OH)D3 1.25(OH)2D3 levels some...
Abstract Hypertensive nephropathy (HN) is a common cause of end-stage renal disease with fibrosis; chronic kidney associated elevated serum gastrin. However, the relationship between gastrin and fibrosis in HN still unknown. We, now, report that mice angiotensin II (Ang II)-induced had increased cholecystokinin receptor B (CCKBR) expression. Knockout CCKBR aggravated, while long-term subcutaneous infusion ameliorated injury interstitial unilateral ureteral obstruction (UUO). The protective...
Abstract Genome-wide association studies (GWAS) have identified many genetic variants in genes related to lipid metabolism. However, how these variations affect levels remains elusive. Long non-coding RNAs (lncRNAs) been implicated a variety of biological processes. We hypothesize lncRNAs are likely be located within disease or trait-associated DNA regions regulate The aim this study was investigate whether and lipid- associated cholesterol homeostasis hepatocytes. In study, we novel long...