A5012875312- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Ion Transport and Channel Regulation
- Eicosanoids and Hypertension Pharmacology
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Acute Kidney Injury Research
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Blood Pressure and Hypertension Studies
- Cancer-related molecular mechanisms research
- Heme Oxygenase-1 and Carbon Monoxide
- Adenosine and Purinergic Signaling
- Metabolomics and Mass Spectrometry Studies
- Sodium Intake and Health
- RNA modifications and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Extracellular vesicles in disease
- Neurological Complications and Syndromes
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Neurotransmitter Receptor Influence on Behavior
Qilu Hospital of Shandong University
2025
Wenzhou City People's Hospital
2025
Chengdu University of Traditional Chinese Medicine
2022-2025
University of Macau
2025
Army Medical University
2014-2024
Daping Hospital
2014-2024
Chinese PLA General Hospital
2007-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Nanjing University of Chinese Medicine
2024
Peking University
2024
Long noncoding RNAs (lncRNAs) have recently been implicated in many biological processes and diseases. Atherosclerosis is a major risk factor for cardiovascular disease. However, the functional role of lncRNAs atherosclerosis largely unknown.We identified lincRNA-p21 as key regulator cell proliferation apoptosis during atherosclerosis. The expression was dramatically downregulated atherosclerotic plaques ApoE(-/-) mice, an animal model Through loss- gain-of-function approaches, we showed...
Extracellular vesicles (EVs) carry signals within or at their limiting membranes, providing a mechanism by which cells can exchange more complex information than what was previously thought. In addition to mRNAs and microRNAs, there are DNA fragments in EVs. Solexa sequencing indicated the presence of least 16434 genomic (gDNA) EVs from human plasma. Immunofluorescence study showed direct evidence that acridine orange-stained EV DNAs could be transferred into localize inside nuclear...
Background Exercise is a major nonpharmacological treatment for hypertension, but its underlying mechanisms are still not completely elucidated. Irisin, polypeptide containing 112 amino acids, which secreted mainly by skeletal muscle cells during exercise, exerts protective role in metabolic diseases, such as diabetes mellitus and obesity. Because of the close relationship between irisin we hypothesized that may play regulation blood pressure. Methods Results Blood pressures male...
Abstract: Irisin, a muscle-origin protein derived from the extracellular domain of fibronectin domain-containing 5 (FNDC5), has been shown to modulate mitochondria welfare through paracrine action. Here, we test hypothesis that irisin contributes cardioprotection after myocardial infarction by preserving mitochondrial function in cardiomyocytes. Animal model studies show intravenous administration exogenous produces dose-dependent protection against ischemia/reperfusion (I/R)-induced injury...
Both oxidative stress and inflammation are involved in the pathogenesis of contrast-induced nephropathy (CIN). Epigallocatechin-3-gallate (EGCG), a purified catechin from green tea, has antioxidant anti-inflammatory effects. However, it is unknown whether or not EGCG effective treating CIN. Our present study found that intravenous administration EGCG, either before just after establishment CIN, had protective effect, determined by normalization serum creatinine blood urea nitrogen levels,...
Mitochondrial (mt) dysfunction and oxidative stress are involved in the pathogenesis of ischemia/reperfusion (I/R)-injury. Lycopene, a lipophilic antioxidant found mainly tomatoes other vegetables fruits, can protect mtDNA against damage. However, role myocardial I/R-injury is unclear. In present study, we aimed to determine if how lycopene protects cardiomyocytes from I/R-injury. both vitro vivo studies, increased mt 8-hydroxyguanine (8-OHdG) content, decreased content transcription levels,...
Our previous study showed that besides mRNAs and microRNAs, there are DNA fragments within extracellular vesicles (EVs). The BCR/ABL hybrid gene, involved in the pathogenesis of chronic myeloid leukemia (CML), could be transferred from K562 EVs to neutrophils decrease their phagocytic activity vitro. present provides evidence DNAs have pathophysiological significance vivo. Two months after injection into tail vein Sprague-Dawley (SD) rats, they some characteristics CML, e.g., feeble,...
Vascular smooth muscle cell (VSMC) phenotype switching is a pathological hallmark in various cardiovascular diseases. N4-acetylcytidine (ac4C) catalyzed by N-acetyltransferase 10 (NAT10) well conserved the enzymatic modification of ribonucleic acid (RNA). NAT10-mediated ac4C acetylation involved physiological and processes, including cardiac remodelling. However, biological functions underlying regulatory mechanisms mRNA modifications vascular diseases remain elusive.
Ischemic injury to neurons represents the underlying cause of stroke brain. Our previous studies identified MG53 as an essential component cell membrane repair machinery. Here we show that recombinant human (rh)MG53 protein facilitates ischemia-reperfusion (IR) rapidly moves acute sites on neuronal cells form a patch. IR-induced brain increases permeability blood-brain-barrier, providing access from blood circulation target injured tissues. Exogenous rhMG53 can protect cultured against...
The renin-angiotensin (Ang) system controls blood pressure, in part, by regulating renal tubular sodium transport. In the kidney, activation of angiotensin II type 1 (AT(1)) receptor increases reabsorption, whereas 2 (AT(2)) produces opposite effect. We hypothesized that AT(2) regulates AT(1) expression and function kidney.In immortalized proximal tubule (RPT) cells from Wistar-Kyoto rats, CGP42112, an agonist, decreased mRNA protein (P < 0.05), as assessed reverse transcriptase-polymerase...
Abstract Background Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain amino acids (BCAA) metabolism can protect against cardiac I/R injury, which may be related to bioactive molecules generated by BCAA metabolites. L-β-aminoisobutyric acid (L-BAIBA), metabolite of BCAA, has multi-organ protective effects, but whether it protects lung unclear. Methods To assess the effect L-BAIBA an animal model was clamping hilum left...
G-protein–coupled receptor kinase 4 (GRK4) gene variants, via impairment of renal dopamine and enhancement renin–angiotensin system functions, cause sodium retention increase blood pressure. Whether GRK4 the angiotensin type 1 (AT R) interact in aorta is not known. We report that expressed vascular smooth muscle cells aorta. Heterologous expression GRK4γ variant 142V A10 increased AT R protein R-mediated intracellular calcium concentration. The was related to an mRNA NF-κB pathway. As...
Medicinal plants are the primary sources for discovery of novel medicines and basis ethnopharmacological research. While existing studies mainly focus on chemical compounds, there is little research about functions other contents in medicinal plants. Extracellular vesicles (EVs) functionally active, nanoscale, membrane-bound secreted by almost all eukaryotic cells. Intriguingly, plant-derived extracellular (PDEVs) also have been implicated to play an important role therapeutic application....
Diabetic macular edema (DME) stands as a leading cause for vision loss among the working-age population. Anti-vascular endothelial growth factor (VEGF) agents are currently recognized first-line treatment. However, significant portion of patients remain insensitive to anti-VEGF, resulting in sustained visual impairment. Therefore, it's imperative predict prognosis and formulate personalized therapeutic regimens. Generative adversarial networks (GANs) have demonstrated remarkably forecasting...
The effects and risks of the use intravenous thrombolysis between 4.5 24 hours after onset a posterior circulation ischemic stroke are not well studied. In trial conducted in China, we randomly assigned patients with stroke, without extensive early hypodensity on computed tomography no planned thrombectomy, to receive alteplase (0.9 mg per kilogram body weight; maximum dose, 90 mg) or standard medical treatment symptoms. primary outcome was functional independence (defined as score 0 2...
The dopaminergic and endothelin systems, by regulating sodium transport in the renal proximal tubule (RPT), participate control of blood pressure. D3 ETB receptors are expressed RPTs, receptor function RPTs is impaired spontaneously hypertensive rats (SHRs). Therefore, we tested hypothesis that can regulate receptors, regulation SHRs. expression RPT cells was measured immunoblotting reverse transcriptase–PCR measuring Na+−K+ ATPase activity. D3/ETB interaction studied co-immunoprecipitation....
Proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the development and progression diabetes-related complications. (−)-Epigallocatechin gallate (EGCG), major catechin derived from green tea, is able to exert antidiabetes effects animal models. However, it not known whether or EGCG inhibits VSMC proliferation induced by high glucose. This study tested hypothesis that might have inhibitory effect on was determined [3H]-thymidine incorporation uptake...
Abstract Hypertensive nephropathy (HN) is a common cause of end-stage renal disease with fibrosis; chronic kidney associated elevated serum gastrin. However, the relationship between gastrin and fibrosis in HN still unknown. We, now, report that mice angiotensin II (Ang II)-induced had increased cholecystokinin receptor B (CCKBR) expression. Knockout CCKBR aggravated, while long-term subcutaneous infusion ameliorated injury interstitial unilateral ureteral obstruction (UUO). The protective...
Soil environmental monitoring is crucial for ensuring the sustainability and productivity of agriculture. This study aims to develop a wireless soil system that utilizes Narrowband Internet Things (NB-IoT), solar energy, Global Positioning System (GPS) technologies address issues high labor demand, costs, delayed feedback in traditional methods. can collect temperature, humidity, meteorological data real time, transmit them cloud platform analysis visualization, predict future data. It...