A5089204718- Diabetes Management and Research
- Diabetes Treatment and Management
- Cancer Immunotherapy and Biomarkers
- Acute Ischemic Stroke Management
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Thyroid Disorders and Treatments
- Ovarian function and disorders
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Disease and Adiposity
- Neuroblastoma Research and Treatments
- Oral health in cancer treatment
- Pregnancy and preeclampsia studies
- Platelet Disorders and Treatments
- Cerebrovascular and genetic disorders
- Diabetic Foot Ulcer Assessment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Circular RNAs in diseases
- Pharmacology and Obesity Treatment
- Gestational Diabetes Research and Management
Second Affiliated Hospital of Zhejiang University
2023-2025
Zhejiang Hospital
2025
Jiaxing University
2025
Zhejiang Chinese Medical University
2023
Zhejiang Cancer Hospital
2023
University of Chinese Academy of Sciences
2023
Shanghai Jiao Tong University
2009-2022
Renji Hospital
2015-2019
First Affiliated Hospital of Guangdong Pharmaceutical University
2019
Wuxi Fourth People's Hospital
2017
To investigate the associations of dyslipidemia with insulin resistance and β cell function in individuals normal glucose tolerance (NGT) different categories impaired regulation (IGR).544 subjects (365 and/or IGR 179 lipid tolerance) were enrolled study. All underwent oral test (OGTT). HOMA-IR was used to evaluate sensitivity. Disposition index (DI) function. Multiple linear regression analysis performed assess correlations among profiles, function.Among NGT, those had higher level but...
Current evidence provides limited support for the superiority of endovascular thrombectomy (EVT) in patients with M2 segment middle cerebral artery occlusion. We aim to investigate whether imaging features occlusion impact effectiveness EVT.
To explore clinical characteristics and beta cell function in Chinese patients with newly diagnosed drug naive type 2 diabetes mellitus (T2DM) different levels of serum triglyceride (TG).Patients T2DM (n = 624) were enrolled divided into groups according to TG. All underwent oral glucose tolerance tests insulin releasing tests. Demographic data, lipid profiles, levels, profiles compared between groups. Basic secretion index (homeostasis model assessment for index, HOMA-β), modified (MBCI),...
1) Background: Infertility and dyslipidemia are frequently present in both women with polycystic ovary syndrome (PCOS) subjects thyroid dysfunction. Limited study regarding the association between stimulating hormone (TSH) level phenotypes euthyroid PCOS women. We aimed to determine whether variation of TSH associates patients. 2) Methods: Cross-sectional including 600 200 age, body mass index (BMI) autoimmunity-matched Chinese from Renji hospital, Shanghai Jiaotong university during January...
The effects and risks of the use intravenous thrombolysis between 4.5 24 hours after onset a posterior circulation ischemic stroke are not well studied. In trial conducted in China, we randomly assigned patients with stroke, without extensive early hypodensity on computed tomography no planned thrombectomy, to receive alteplase (0.9 mg per kilogram body weight; maximum dose, 90 mg) or standard medical treatment symptoms. primary outcome was functional independence (defined as score 0 2...
White matter injury (WMI) is associated with cognitive dysfunction in aging population; however, a clinicoradiological discrepancy often arises between WMI and cognition function clinical practice. Emerging evidence suggests that the glymphatic system plays crucial role clearing metabolic waste maintaining function. We hypothesize may contribute to this by moderating impact of on cognition. conducted retrospective review community-dwelling residents our center who underwent multimodal MRI...
Is the secretion of gastrointestinal hormones impaired in patients with polycystic ovary syndrome (PCOS)? Gastrointestinal hormone levels were abnormal PCOS. The glucagon-like peptide-1 (GLP-1) and peptide tyrosine–tyrosine (PYY) are both involved signaling satiety. Secretion GLP-1 PYY response to nutrients small intestine plays an important role energy metabolism. Most PCOS overweight or obese, which suggests dysregulation appetite. In order evaluate PCOS, a cohort study was undertaken,...
Background Apolipoprotein B/apolipoprotein A-I (ApoB/ApoA-I) ratio is a useful predictor of cardiovascular risk. However, the association between ApoB/ApoA-I and risk type 2 diabetes mellitus (T2DM) still obscure. Aims To investigate associations T2DM pre-diabetes in Chinese population, to assess role gender these associations. Methods A stratified random sampling design was used this cross-sectional study which included 264 men 465 women with normal glucose tolerance (NGT), or T2DM. Serum...
B7-H6, a member of the B7 family molecules, participates in clearance tumor cells by binding to NKp30 on NK cells. B7-H6 expression level esophageal squamous cell carcinoma (ESCC) and clinical value remain unknown. The goal this study was determine ESCC further explore its significance. We retrospectively collected data 145 patients diagnosed with between January 2007 December 2008. pathological tissue samples detected immunohistochemistry. chi-square (χ2) test used analyse relationships...
Immunotherapy-associated hypophysitis is an uncommon adverse event. However, if not handled properly, it could lead to fatal sequelae.Case 1. A 66-year-old man presented our hospital with hyponatremia. He had low plasma levels of adrenocorticotropin and cortisol. The patient a history non-small cell lung cancer undergone 16 cycles immunotherapy sintilimab, monoclonal antibody against programmed death protein 1 (PD1). was diagnosed adrenal insufficiency secondary immunotherapy-associated...
Current evidence suggests a potential association between cerebral microbleeds (CMBs), low-density lipoprotein cholesterol (LDL-C) levels, and statin use, but the exact relationship remains unclear. This study aims to prospectively examine these relationships in stroke-free population.From January 2010 2020, we enrolled individuals with at least one small vessel disease imaging marker from CIRCLE (ClinicalTrials.gov ID: NCT03542734). Participants underwent baseline 1-year follow-up...
Background: Insulin autoimmune syndrome (IAS) is a rare cause of hypoglycemia that characterized by hyperinsulinemia, hypoglycemia, and high autoantibody titer. About 50% patients with IAS have taken medication containing sulfhydryl (-SH) groups. We present case developed after taking clopidogrel, drug an active metabolite contains SH-group. Case report: was suspected in 63-year-old Chinese man because concentrations insulin C-peptide during hypoglycemic episodes, positivity for anti-insulin...
The aim of the present study was to investigate serum levels free triiodothyronine (FT3), thyroxine (FT4) and thyroid stimulating hormone (TSH) during pregnancy comparative analysis markers in non-pregnant women pregnant women. Pregnant were divided into four groups according their gestational age: 8-14, 15-20, 21-36 ≥37 weeks. Non-pregnant three 20-40, 41-55 56-85 years, reproductive age (20-40 years) as control, which match body mass index with measured by magnetic microparticle...
Background . It has been well accepted that insulin therapy is the ideal treatment for newly diagnosed diabetic patients. However, there was no study about assessment of initial dosage in new onset Chinese patients with type 2 diabetes. Research Design and Methods 65 diabetes (39 males/26 females; HbA1c ≥ 11.80 ± 0.22%) were investigated. All had random hyperglycaemia (at 21.8 3.9 mmol/L) on first day admission received infusion intravenously (5 U/per hour). When blood glucose level dropped...
Cancer pain is a common symptom in cancer patients. However, few reports have evaluated the effect of baseline on efficacy immunotherapy lung The aim this retrospective study to reveal prognosis patients receiving immunotherapy.We retrospectively reviewed medical records who received at Zhejiang Hospital and were included 280 with or without pain. Propensity score matching (PSM) was used minimize potential selection bias. Progression-free survival (PFS) overall (OS) assessed using...
To investigate the safety of early antiplatelet therapy for non-cardioembolic mild stroke patients with thrombocytopenia.
Objective: It is established that early insulin therapy can improve both β cell function and glycaemic control in newly diagnosed type 2 diabetic patients.The dipeptidyl peptidase-4 (DPP-4) inhibitor, sitagliptin, preserve or even increase the number of cells animal models diabetes.Therefore, we aimed to determine whether treatment with sitagliptin after initial intensive would further reduce glycaemia new-onset diabetes.Methods: 48 Chinese patients diabetes (fasting blood glucose...
Objective To assess the clinical safety and efficacy of multi-parameter bolus advisor in insulin pump therapy explore application value advisor. Methods A total 158 diabetic patients from endocrine departments 10 tertiary comprehensive hospitals were randomly (2∶1∶1) assigned to three groups May 2012 July 2013, including with form continuous subcutaneous infusion (CSII) (BA-CSII group), common CSII system (CO-CSII multiple daily injection (MDI group). The dosage, blood glucose...