A5034403741- Hip and Femur Fractures
- Cancer-related molecular mechanisms research
- Cardiac, Anesthesia and Surgical Outcomes
- RNA modifications and cancer
- Acute Ischemic Stroke Management
- Identification and Quantification in Food
- Leech Biology and Applications
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- CAR-T cell therapy research
- RNA Research and Splicing
- Diet and metabolism studies
- Nanoplatforms for cancer theranostics
- Scoliosis diagnosis and treatment
- Immune cells in cancer
- Advanced Nanomaterials in Catalysis
- High Altitude and Hypoxia
- Pulmonary Hypertension Research and Treatments
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Species Distribution and Climate Change
- Nutrition, Genetics, and Disease
- Thyroid Cancer Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
Chongqing Jiaotong University
2025
City of Hope
2023-2025
Beckman Research Institute
2023-2025
Northwest A&F University
2025
University of South China
2019-2024
Air Force Medical University
2024
Tianjin University of Sport
2021-2024
Igenbio (United States)
2024
Beijing Institute of Petrochemical Technology
2024
South China Agricultural University
2024
The lack of high-throughput methods to analyze the adipose tissue protein composition limits our understanding networks responsible for age and diet related metabolic response. We have developed an approach using multiple-dimension liquid chromatography tandem mass spectrometry extended multiplexing (24 biological samples) with tags (TMT) labeling proteomes epididymal tissues isolated from mice fed either low or high fat a short long-term, that aged on versus diets. peripheral health (as...
Abstract Mitochondrial dysfunction of cardiomyocytes (CMs) has been identified as a significant pathogenesis early myocardial infarction (MI). However, only few agents or strategies have developed to improve mitochondrial for the effective MI treatment. Herein, reactive oxygen species (ROS)‐responsive PAMB‐G‐TK/4‐arm‐PEG‐SG hydrogel is localized drug‐loaded liposome delivery. Notably, liposomes contain both elamipretide (SS‐31) and sphingosine‐1‐phosphate (S1P), where SS‐31 acts an inhibitor...
Abstract Background and Purpose Chronic kidney disease (CKD) is characterised by inflammation, which can lead to tubular atrophy fibrosis. The molecular mechanisms are not well understood. In this study, we investigated the functional role of cyclic GMP–AMP synthase (cGAS)– stimulator interferon genes (STING) signalling in renal inflammation Experimental Approach Mice with global cGAS deficiency or myeloid cell‐specific STING wild‐type mice treated RU.521, a selective inhibitor, were used...
Genome-wide association studies have to date identified 159 significant and suggestive loci for coronary artery disease (CAD). We now report comprehensive bioinformatics analyses of sequence variation in these predict candidate causal genes.All annotated genes the were evaluated with respect protein-coding single-nucleotide polymorphism gene expression parameters. The latter included quantitative trait loci, tissue specificity, miRNA binding. High priority further based on literature...
Tumors display widespread transcriptome alterations, but the full repertoire of isoform-level alternative splicing in cancer is unknown. We developed a long-read (LR) RNA sequencing and analytical platform that identifies annotates full-length isoforms infers tumor-specific events. Application this to breast samples thousands previously unannotated isoforms; ~30% affect protein coding exons are predicted alter localization function. performed extensive cross-validation with -omics datasets...
Highlights•Fructose promotes transcriptomic and epigenomic reprogramming to perturb brain networks linking metabolism function.•The extracellular matrix genes Bgn Fmod emerge as key regulators of gene responsive fructose.•The omega-3 fatty acid DHA reverses fructose-induced genomic network reprogramming.Meng et al. report fructose a powerful inducer variability with the capacity reorganize critical for central metabolic regulation neuronal processes in brain; conversely, an acid, DHA, has...
Recent genome-wide association studies of coronary artery disease (CAD) have revealed 58 significant and 148 suggestive genetic loci. However, the molecular mechanisms through which they contribute to CAD clinical implications these findings remain largely unknown. We aim retrieve gene subnetworks 206 loci identify prioritize candidate regulators better understand biological underlying associations.
To overcome the oxidative stress and resistance of cancer stem cells (CSCs) for successful metastatic triple-negative breast (TNBC) treatment, we report polyhedral oligosilsesquioxanes (POSS)-based metal-phenolic networks (MPNs) that integrate hard POSS as a rigid dendritic macromolecular moiety binding with photosensitizer (PS), Chlorin e6 (Ce6) to improve reactive oxygen species (ROS) generation efficiency photodynamic therapy (PDT), soft metal ions dynamic coordination-driven...
The occurrence and development of tumors require the metabolic reprogramming cancer cells, namely alteration flux in an autonomous manner via various pathways to meet increased bioenergetic biosynthetic demands. Tumor cells consume large quantities nutrients produce related metabolites their metabolism; this leads remodeling tumor microenvironment (TME) better support growth. During TME remodeling, immune cell metabolism antitumor activity are affected. This further escape from surveillance...
To functionally link coronary artery disease (CAD) causal genes identified by genome wide association studies (GWAS), and to investigate the cellular molecular mechanisms of atherosclerosis, we have used chromatin immunoprecipitation sequencing (ChIP-Seq) with CAD associated transcription factor TCF21 in human smooth muscle cells (HCASMC). Analysis target for enrichment annotation terms processes relevant pathophysiology, including "growth binding," "matrix interaction," "smooth...
Abstract Background Long-term poor posture may affect the morphological development of spine. However, there is no definite answer as to how writing affects students’ This study attempted compare sagittal curvature spine between sitting and standing postures in adolescents reveal variation rule spinal students with learning posture, discover key factors that health. Methods 1138 participants (male, 604; female, 534; age range, 6–18 years) from three schools Tianjin, China, including 570...
Acute lymphoblastic leukemia (ALL) is characterized by abnormal lymphoblasts accumulation in the bone marrow and blood. Despite great efforts have been made exploring novel therapeutic method, prognosis of children with ALL still unsatisfied. Glucocorticoid (GC) resistance a obstacle for clinical treatment ALL. Therefore, it essential to investigate molecular mechanism underlying GC resistance. According previous reports, long noncoding RNAs (lncRNAs) are involved drug various human cancers....
In a GM-CSF driven myeloid cell deficient mouse model (Csf2-/-) that has preserved insulin sensitivity despite increased adiposity, we used unbiased three-dimensional integration of proteome profiles, metabolic and gene regulatory networks to understand adipose tissue proteome-wide changes their implications. Multi-dimensional liquid chromatography mass spectrometry extended multiplex labeling was analyze proteomes epididymal tissues isolated from Csf2+/+ Csf2-/- mice were fed low fat, high...
Type 2 diabetes (T2D) has become an increasingly challenging health burden due to its high morbidity, mortality, and heightened prevalence worldwide. Although dietary nutritional imbalances have long been recognized as key risk factors for T2D, the underlying mechanisms remain unclear. The advent of systems biology, a field that aims elucidate interactions between nutrients endogenous molecular entities in disease-related tissues, offers unique opportunities unravel complex health-modifying...
Leeches are classic annelids that have a huge diversity and closely related to people, especially medicinal leeches. Medicinal leeches been widely utilized in medicine based on the pharmacological activities of their bioactive ingredients. Comparative genomic study these enables us understand difference among other facilitates discovery ingredients.In this study, we reported genome Whitmania pigra compared it with Hirudo medicinalis Helobdella robusta. The assembled size W. is 177 Mbp, close...