A5100689991- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA modifications and cancer
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Virus-based gene therapy research
- Plant Molecular Biology Research
- Cancer-related gene regulation
- Pulmonary Hypertension Research and Treatments
- CRISPR and Genetic Engineering
- Photosynthetic Processes and Mechanisms
- Lipid metabolism and biosynthesis
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Biocrusts and Microbial Ecology
- Epigenetics and DNA Methylation
- Polyamine Metabolism and Applications
- Phytochemistry and Bioactivity Studies
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- NF-κB Signaling Pathways
- Silicon Effects in Agriculture
- PI3K/AKT/mTOR signaling in cancer
- Ferroptosis and cancer prognosis
Guizhou University
2023-2024
Tongji University
2021-2024
Yangzhou University
2024
ZheJiang Academy of Agricultural Sciences
2024
Ningbo University
2024
Henan Agricultural University
2024
Shanghai Pulmonary Hospital
2021-2024
Hebei Medical University
2023-2024
Second Hospital of Hebei Medical University
2023-2024
Sun Yat-sen University
2022
Abstract Laryngeal squamous cell carcinoma (LSCC) is a common malignancy of the head and neck. Recently, circular RNA (circRNA) has been studied extensively in multisystem diseases. However, there are few research on biological functions molecular mechanisms circRNAs LSCC. CircRNA array was used to detect differentially expressed circRNAs. Kaplan–Meier cox regression analysis were identify survival based circMMP9. The qRT-PCR, RNase R treatment, sanger sequencing situ hybridization verify...
Hemophilia A is a monogenic disease with blood clotting factor VIII (FVIII) deficiency caused by mutation in the (F8) gene. Current and emerging treatments such as FVIII protein injection gene therapies via AAV-delivered F8 transgene an episome are costly nonpermanent. Here, we describe CRISPR/Cas9-based vivo genome editing method, combined non-homologous end joining, enabling permanent chromosomal integration of modified human B domain deleted-F8 (BDD-F8) at albumin (Alb) locus liver cells....
Acute lymphoblastic leukemia (ALL) is characterized by abnormal lymphoblasts accumulation in the bone marrow and blood. Despite great efforts have been made exploring novel therapeutic method, prognosis of children with ALL still unsatisfied. Glucocorticoid (GC) resistance a obstacle for clinical treatment ALL. Therefore, it essential to investigate molecular mechanism underlying GC resistance. According previous reports, long noncoding RNAs (lncRNAs) are involved drug various human cancers....
Human dental pulp cells (hDPCs) possess the capacity to differentiate into odontoblast-like in response exogenous stimuli. Histone methylation is one of most robust epigenetic marks and essential for regulation multiple cellular processes. Previous studies have shown that histone methyltransferases (HMTs) demethylases (HDMs) are crucial osteogenic differentiation human bone marrow, adipose tissue, tooth tissue. However, little known about role hDPC differentiation. Here, expression levels...
Elicitation is a well-known strategy for increasing the accumulation of secondary metabolites in callus cultures. In this study, induction system Saxifraga stolonifera Meerb. was developed, and elicitors were used to enhance metabolite production. Tender leaves S. as explants vitro culture. We examined characteristics its response various by assessing sterilization conditions explants, varying hormone ratios, determining optimal concentrations salicylic acid (SA), Sodium nitroprusside (SNP)...
Abstract Deubiquitinases (DUBs) regulate diverse biological processes and represent a novel class of drug targets. However, the function only small fraction DUBs, especially in adaptive immune response regulation, is well-defined. In this study, we identified DUB ubiquitin-specific peptidase 12 (USP12) as critical regulator CD4 + T cell activation. USP12 plays an intrinsic role promoting phenotype, including differentiation, activation, proliferation. Although USP12-deficient cells protected...
The young shoots of the tea plant Baiye No. 1 display an albino phenotype in early spring under low environmental temperatures, and leaves re-green like those common cultivars during warm season. Periodic albinism is precisely regulated by a complex gene network that leads to metabolic differences enhances nutritional value leaves. Here, we identified messenger RNAs (mRNAs), long noncoding (lncRNAs), circular (circRNAs), microRNAs (miRNAs) construct competing endogenous RNA (ceRNA)...
Long noncoding RNA HOXB cluster antisense 3 (HOXB-AS3) has been reported to be dysregulated in several tumors. The present study mainly aims at the investigation how HOXB-AS3 works epithelial ovarian cancer (EOC) and elucidate mechanism involved. Initially, 'GEPIA' was mined examine differential expression levels prognostic value of EOC patients. cell lines patient specimens examined with quantitative RT-PCR. Simultaneously, correlation a variety clinicopathological factors survival...
Circular RNAs can serve as regulators influencing the development of pulmonary hypertension (PH). However, their function in vascular intimal injury remains undefined. Thus, we aimed to identify specifically expressed circular microvascular endothelial cells (PMECs) under hypoxia and PH.
Metastatic castration-resistant prostate cancer (mCRPC) is a lethal form of cancer, and the molecular mechanism driving mCRPC progression has not yet been fully elucidated. Immunotherapies such as chimeric antigen receptor, T-cell therapy immune checkpoint blockade have exerted promising antitumor effects in hematological solid tumor malignancies; however, no encouraging responses observed against mCRPC. The deubiquitinase USP13 functions suppressor many human cancers, it sustains protein...
Abstract Polyamine biosynthesis is an essential metabolic pathway for cell growth and differentiation in non-small-cell lung cancer (NSCLC). Fragile-site associated tumour suppressor (FATS) a novel gene involved cancer. The results of our previous study showed that FATS-mediated polyubiquitination p53 promotes the activation response to DNA damage; however, little known about role FATS reprogramming NSCLC. In present study, was observed be significantly downregulated NSCLC tissues compared...
At present, the role of lncRNAs in pathogenesis hypoxia-induced pulmonary hypertension (HPH) is not fully understood. This study aimed to explore differences expression and their potential multiple artery cells.LncRNA smooth muscle cells (PASMCs), microvascular endothelial (PMECs), pericytes (PCs) was analyzed by high-throughput sequencing compared between normoxic hypoxic cells. Bioinformatics analysis conducted predict functions.PASMCs, PMECs, PCs displayed 275 (140 upregulated), 251 (162...
Objective. Pediatric asthma is still a health threat to the children. Long noncoding RNA-NEAT1 (lncRNA-NEAT1) was reported be positively correlated with severity of asthma. We aimed study effects and mechanism lncRNA-NEAT1on inflammatory reaction phenotypic transformation airway smooth muscle cells (ASMCs) in bronchial Method. The degree lncRNA-NEAT1 miR-128 mRNA children healthy individuals tested by qRT-PCR. After PDGF-BB-induced ASMCs, expression or AMSC disturbed AMSC. Subsequently,...
Akebia trifoliata is a medicinal plant with high oil content and broad pharmacological effects. To investigate the regulatory mechanisms of key metabolic pathways during seed development, we conducted an integrated multi-omics analysis, including transcriptomics, proteomics, metabolomics, exploring dynamic changes in carbon lipid metabolism. Metabolomics analysis revealded that glucose sucrose levels decreased, while glycolytic intermediate phosphoenolpyruvate fatty acids increased...
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In order to get know the imitation of wild Gastrodia elata in life history and phenology period, by G. f. forest simulated cultivation Dafang county, Guizhou province, observing recording its morphological characteristics each growth development stage. This experiment summarized law over 24 months, amplified 5 periods sexual asexual reproduction cultivated Guizhou. Which results could clear process Guizhou, provide a theoretical support for standard technical elata.
The incidence of prostate cancer (PC) is growing rapidly worldwide, and studies uncovering the molecular mechanisms driving progression modulating immune infiltration antitumor immunity PC are urgently needed. long noncoding RNA SNHG family has been recognized as a prognostic marker in cancers contributes to multiple cancers, including PC. In this study, we aimed clarify values underlying SNHGs promoting tumor microenvironment through data mining based on Cancer Genome Atlas (TCGA) database....