A5100784682- TGF-β signaling in diseases
- Mesenchymal stem cell research
- Obesity, Physical Activity, Diet
- Reconstructive Facial Surgery Techniques
- Esophageal Cancer Research and Treatment
- Cancer-related Molecular Pathways
- Birth, Development, and Health
- Cancer Cells and Metastasis
- Ear and Head Tumors
- Epigenetics and DNA Methylation
- Bone Metabolism and Diseases
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Chronic Myeloid Leukemia Treatments
- Child Nutrition and Water Access
- Breastfeeding Practices and Influences
- Liver Disease Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Cell Adhesion Molecules Research
- Bone health and treatments
- Hedgehog Signaling Pathway Studies
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
Shanxi Medical University
2020-2025
Qingdao Women and Children's Hospital
2025
Qingdao University
2025
Ningbo University
2025
Beijing Sport University
2025
First Affiliated Hospital of Henan University
2023-2025
Guangzhou Medical University
2024-2025
Chinese Academy of Fishery Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Shanghai Jiao Tong University
2015-2024
Nutrients are absorbed solely by the intestinal villi. Aging of this organ causes malabsorption and associated illnesses, yet its aging mechanisms remain unclear. Here, we show that aging-caused villus structural functional decline is regulated mTORC1, a sensor nutrients growth factors, which highly activated in stem progenitor cells geriatric mice. These phenotypes recapitulated cell-specific Tsc1 knockout Mechanistically, mTORC1 activation increases protein synthesis MKK6 augments p38...
Significance Hybrid rice developed in China has been contributing greatly to the world’s food production. The pioneer super hybrid by crossing 93–11 and Peiai 64s , Liang–You–Pei–Jiu widely grown other Asia-Pacific regions for its high yield. Here, quality genome sequences both parental lines were presented updated, a high-resolution map of genome-wide graphic genotypes was constructed deep resequencing core population 132 recombinant inbred lines. A series yield-associated loci fine-mapped,...
Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly activated in cartilage and bone tumors. Yet deletion Ptch1, encoding an inhibitor IHH receptor Smoothened (SMO), chondrocyte or osteoblasts does not cause tumorigenesis. Here, we show that Ptch1 mice Prrx1+mesenchymal stem/stromal cells (MSCs) promotes MSC proliferation osteogenic chondrogenic differentiation but inhibits adipogenic differentiation. Moreover, led to development osteoarthritis-like phenotypes,...
Dietary micronutrient deficiencies, such as the lack of vitamin A, are a major source morbidity and mortality worldwide. Carotenoids in food can function provitamin A humans, while grains Chinese elite wheat cultivars generally have low carotenoid contents. To increase contents common endosperm, transgenic has been generated by expressing maize y1 gene encoding phytoene synthase driven endosperm-specific 1Dx5 promoter (Triticum aestivum L.) variety EM12, together with bacterial desaturase...
Melatonin, an endogenously produced neurohormone secreted by the pineal gland, has a variety of physiological functions and neuroprotective effects. It can modulate neural stem cells (NSCs) including proliferation differentiation in embryonic brain tissue but its effect mechanism on hypoxia remains to be explored. Here, we show that melatonin stimulates NSCs during hypoxia. Additionally, it also promoted into neurons. However, did not appear exert obvious astrocytes. The present results have...
Platelet-derived growth factors (PDGFs) play important roles in skeletal development and bone fracture healing, yet how PDGFs execute their functions remains incompletely understood. Here we show that PDGF-AA, but not -AB or -BB, could activate the BMP-Smad1/5/8 pathway mesenchymal stem cells (MSCs), which requires BMPRIA as well PDGFRα. PDGF-AA promotes MSC osteogenic differentiation through BMP-Smad1/5/8-Runx2/Osx axis migration via BMP-Smad1/5/8-Twist1/Atf4 axis. Mechanistic studies...
Abstract Bone mass is determined by the balance between bone formation, carried out mesenchymal stem cell-derived osteoblasts, and resorption, monocyte-derived osteoclasts. Here we investigated potential roles of p38 MAPKs, which are activated growth factors cytokines including RANKL BMPs, in osteoclastogenesis resorption ablating p38α MAPK LysM+monocytes. deficiency promoted monocyte proliferation but regulated osteoclastic differentiation a cell-density dependent manner, with proliferating...
Abstract Chronic inflammation has been implicated as an etiologic factor in cancer, whereas autophagy may help preserve cancer cell survival but exert anti-inflammatory effects. How these phenomenas interact during carcinogenesis remains unclear. We explored this question a human bronchial epithelial cell–based model of lung that is mediated by subchronic exposure to arsenic. found sustained overexpression the pro-inflammatory IL6 promoted arsenic-induced transformation inhibiting autophagy....
// Deyong Jia 1 , Yuan Tan Huijuan Liu 1, 2 Sarah Ooi Li Kathryn Wright Steffany Bennett Christina L. Addison 3 Lisheng Wang 4, 5 Department of Biochemistry, Microbiology and Immunology, Faculty Medicine, University Ottawa, Ontario K1H 8M5, Canada Bio-X Institutes, Key Laboratory for the Genetics Developmental Neuropsychiatric Disorders, Ministry Education, Shanghai Jiao Tong University, 200240, China Centre Cancer Therapeutics, Ottawa Hospital Research Institute, 8L6, 4 Regenerative...
Abstract Background The global issue of low breastfeeding rates has been widely reported. Quantitative studies have shown the positive effects peer support on breastfeeding. However, experiences mothers who receive found to vary. To date, no systematic qualitative summary conducted document impact support, nor provide advice for its implementation from perspective mothers. This review aims systematically synthesize findings mothers’ evidence optimizing services and ultimately enhancing their...
Abstract Chronic atrophic gastritis (AG) is initiated mainly by Helicobacter pylori infection, which may progress to stomach cancer following the Correa's cascade. The current treatment regimen H. eradication, yet evidence lacking that this effective on later stages of AG especially gastric gland atrophy. Here, using mouse model, patient samples, organoids, and lineage tracing, study unraveled stem cell (GSC) defect as a crucial pathogenic factor in human. Moreover, natural peptide isolated...
Grifola frondosa polysaccharide (GFP) is a consumable fungus recognized for its potential health advantages. The present study aimed to investigate the development and etiologies of ulcerative colitis (UC) utilizing oxazolone (OXZ) as an inducer in mice, along with assessing therapeutic effects GFP at varying doses UC sulfasalazine (SASP) serving positive control. obtained results indicated that OXZ intervention mice induced numerous physical manifestations UC, including increased disease...
Neural stem cells (NSCs) play essential roles in nervous system development and postnatal neuroregeneration their deregulation underlies the of neurodegenerative disorders. Yet how NSC proliferation differentiation are controlled is not fully understood. Here we present evidence that tumor suppressor p53 regulates via bone morphogenetic proteins (BMP)-Smad1 pathway its target gene inhibitor DNA binding 1 (Id1). deficiency led to increased neurogenesis vivo, biased neuronal augmented ex vivo...
Esophageal squamous cell carcinoma (ESCC) is a malignant upper digestive tract cancer, and its pathogenesis etiology are poorly understood. Because gut microbes commonly impact progression, metastasis, immunotherapy responses in colorectal cancer (CRC), the roles of esophageal microbiota ESCC have gradually drawn attention. As reported previously, Fusobacterium nucleatum (Fn), notable "culprit" CRC, can also influence prognosis clinical studies. However, thus far, underlying mechanism...
DNA damage and the elicited cellular response underlie etiology of tumorigenesis ageing. Yet, how this integrates inputs from cells' environmental cues remains underexplored. Here we report that BMP-Smad1 pathway, which is essential for embryonic development tissue homeostasis, has an important role in oncogenesis. On genotoxic stress, Atm phosphorylates BMPs-activated Smad1 nucleus on S239, disrupts interaction with protein phosphatase PPM1A, leading to enhanced activation upregulation...
Resident stromal cells suppress IBD pathogenesis in mice.
Objectives To investigate the safety and therapeutic efficacy of autologous olfactory ensheathing cell (OEC) transplantation in cervical spinal cord injury (SCI). Methods Patients with SCI >6 months’ duration were treated OECs, injected into area surrounding under magnetic resonance imaging guidance, twice a week for 4 weeks. evaluated before treatment at 3, 6, 12 24 months post-treatment, using American Spinal Injury Association (ASIA) Impairment Scale, ASIA sensory motor score...