A5041822106- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Blood Coagulation and Thrombosis Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Statistical Methods in Clinical Trials
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Liver Diseases and Immunity
- Venomous Animal Envenomation and Studies
- Multiple Myeloma Research and Treatments
- Computational Drug Discovery Methods
- COVID-19 and Mental Health
- Vitamin K Research Studies
- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
- Gastrointestinal motility and disorders
- Protease and Inhibitor Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Gastrointestinal disorders and treatments
- Pleural and Pulmonary Diseases
- Neonatal Respiratory Health Research
Wuhan Pulmonary Hospital
2019-2025
Renmin Hospital of Wuhan University
2008-2025
Wuhan University
2008-2025
Shanghai Jiao Tong University
2015-2024
Ruijin Hospital
2022-2024
Hangzhou First People's Hospital
2024
Shanghai Public Health Clinical Center
2020-2024
Anhui University of Traditional Chinese Medicine
2024
Shanghai Institute of Pharmaceutical Industry
2024
Fudan University
2003-2024
Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP are polymorphic, with common alleles conferring reduced function.We tested the association between functional genetic variants in genes, plasma concentrations of drug metabolite, and platelet inhibition response to clopidogrel 162 healthy subjects. We then examined these cardiovascular outcomes a separate cohort 1477 subjects acute coronary...
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes disease 2019 (Covid-19), which is most frequently mild yet can be severe and life-threatening. Virus-neutralizing monoclonal antibodies are predicted to reduce viral load, ameliorate symptoms, prevent hospitalization.MethodsIn this ongoing phase trial involving outpatients with recently diagnosed or moderate Covid-19, we randomly assigned 452 patients receive a single intravenous infusion of neutralizing antibody...
The biological mechanisms linking obesity to insulin resistance have not been fully elucidated. We shown that or glucose intolerance in diet-induced obese mice is related a shift the ratio of pro- and anti-inflammatory T cells adipose tissue. sought test hypothesis balance T-cell phenotypes would be similarly human obesity.Healthy overweight subjects underwent adipose-tissue biopsies quantification insulin-mediated disposal by modified suppression test. subsets were quantified flow cytometry...
<h3>Importance</h3> Preventive interventions are needed to protect residents and staff of skilled nursing assisted living facilities from COVID-19 during outbreaks in their facilities. Bamlanivimab, a neutralizing monoclonal antibody against SARS-CoV-2, may confer rapid protection SARS-CoV-2 infection COVID-19. <h3>Objective</h3> To determine the effect bamlanivimab on incidence among <h3>Design, Setting, Participants</h3> Randomized, double-blind, single-dose, phase 3 trial that enrolled 74...
The current pathological and molecular classification of pancreatic ductal adenocarcinoma (PDAC) provides limited guidance for treatment options, especially immunotherapy. Cancer-associated fibroblasts (CAFs) are major players desmoplastic stroma in PDAC, modulating tumor progression therapeutic response. Using single-cell RNA sequencing, we explored the intertumoral heterogeneity among PDAC patients with different degrees desmoplasia. We found substantial CAFs, cancer cells, immune cells...
IgA, the predominant isotype in secretions, mediates neutralization and removal of environmental antigens from mucosal sites. Although cell surface receptors for Fc region IgA (Fc alpha R) have been implicated a variety immune effector mechanisms, molecular features R remain only marginally characterized. In this report, we describe isolation clone myeloid line cDNA library that directs expression molecule with binding specificity. The encodes peptide Mr 30,000 including putative...
T helper cells that produce IL-17 (Th17 cells) have recently been identified as the third distinct subset of effector cells. Emerging data suggests Th17 play an important role in pathogenesis many liver diseases by regulating innate immunity, adaptive and autoimmunity. In this study, we examine mechanism autoimmune hepatitis (AIH). The serum levels IL-23, well frequency IL-17+ liver, were significantly elevated patients with AIH, compared to other chronic healthy controls. hepatic...
Obesity-related insulin resistance correlates with type I interferon–driven activation and expansion of intrahepatic T cells. See the related Focus by Ma et al .
Abstract Background Macrophage polarization and reprogramming in the lung play a critical role initiation, development progression of acute injury (ALI). Regulating activation differentiation pulmonary macrophages may provide potential therapeutic strategy to treat ALI. We previously developed novel class anti-inflammatory nanoparticles (P12) that can potently inhibit Toll-like receptor (TLR) signaling macrophages. These bioactive nanodevices were made gold (GNPs) coated with hexapeptides...
Obesity-associated insulin resistance, a common precursor of type 2 diabetes, is characterized by chronic inflammation tissues, including visceral adipose tissue (VAT). Here we show that B-1a cells, subpopulation B lymphocytes, are novel and important regulators this process. cells reduced in frequency obese high-fat diet (HFD)-fed mice, EGFP interleukin-10 (IL-10) reporter mice marked reductions anti-inflammatory IL-10 production vivo during obesity. In VAT, the dominant producers...
Pathogenic factors driving obesity to type 2 diabetes (T2D) are not fully understood. Group 1 innate lymphoid cells (ILC1s) effectors of immunity and enriched in inflamed tissues. Here we show that the number adipose ILC1s increases obese T2D patients correlates with glycemic parameters blood; circulating ILC1 numbers decrease as a result metabolic improvements after bariatric surgery. In vitro co-culture experiments human promote fibrogenesis CD11c+ macrophage activation. Reconstruction...
Innate lymphoid cells (ILCs) are tissue-resident lymphocytes differing from conventional T in having no antigen-specific receptors. ILCs include natural killer (NK) cells, helper-like ILC1s, ILC2s, and ILC3s, tissue-inducer (LTi) cells. Tumor frequently found various cancers, but their roles cancer immunity immunotherapy remain largely unclear. We report here the single-cell characterization of blood gut ILC subsets healthy conditions colorectal (CRC). The contains ILC3/NKs, ILC2s....
Group 2 innate lymphoid cells (ILC2s) are highly heterogeneous tissue-resident lymphocytes that regulate inflammation and tissue homeostasis in health disease. However, how these integrate into the microenvironment to perform tissue-specific functions is unclear. Here, we show neuropilin-1 (Nrp1), which induced postnatally sustained by lung-derived transforming growth factor beta-1 (TGFβ1), a marker of lung ILC2s. Genetic ablation or pharmacological inhibition Nrp1 suppresses IL-5 IL-13...
To determine the prevalence of nonalcoholic fatty liver in a specific population Shanghai by an epidemiological survey, and to analyze risk factors liver.Total 4009 administrative officers who denied regular alcohol drinking participated underwent physical examination laboratory tests. The important parameters were body mass index (BMI), waist hip circumferences ratio (WHR) levels serum lipids. Diagnosis was based on established real-time ultrasonographic criteria, presence pattern...
Obesity-related inflammation of metabolic tissues, including visceral adipose tissue (VAT) and liver, are key factors in the development insulin resistance (IR), though many contributing mechanisms remain unclear. We show that nucleic-acid-targeting pathways downstream extracellular trap (ET) formation, unmethylated CpG DNA, or ribonucleic acids drive IR. High-fat diet (HFD)-fed mice increased release ETs VAT, decreased systemic clearance ETs, autoantibodies against conserved nuclear...
Abstract Background and Aims: Although irritable bowel syndrome (IBS) is a common disorder in the West, information on prevalence of IBS university students relatively scant, especially Asia. The aims present study were to investigate pattern symptoms its relationship with psychological stress status Chinese students. Methods: Basic demographic data sought using Rome II criteria validated symptom questionnaire. Another questionnaire used related psychosomatic depression anxiety. Results: In...
MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. Several studies have indicated abnormal expression miRNAs occurs frequently in human osteosarcoma. In the present study, we found miR-128 was significantly increased osteosarcoma tissues compared to adjacent normal tissues. Ectopic overexpression promoted while suppression by its antisense inhibited proliferation MG63 and U2OS cells. At...