A5100322983- Immune cells in cancer
- interferon and immune responses
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- T-cell and B-cell Immunology
- NF-κB Signaling Pathways
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Stress Responses and Cortisol
- Cytokine Signaling Pathways and Interactions
- Tryptophan and brain disorders
- RNA regulation and disease
- RNA and protein synthesis mechanisms
- Diet, Metabolism, and Disease
- Systemic Lupus Erythematosus Research
- Sesquiterpenes and Asteraceae Studies
- Inflammasome and immune disorders
- Galectins and Cancer Biology
- Bone Metabolism and Diseases
- Inflammation biomarkers and pathways
University of Chinese Academy of Sciences
2006-2025
Institute of Psychology, Chinese Academy of Sciences
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2025
Shanghai Jiao Tong University
2016-2025
Wuhan University
2013-2025
Ruijin Hospital
2019-2025
Renmin Hospital of Wuhan University
2025
Shanghai Institute of Hematology
2019-2025
Guang’anmen Hospital
2025
Sichuan University
2022-2025
Significance Multiple myeloma (MM) is one of the most common hematological malignancies. Developing an effective treatment strategy for refractory/relapsed (R/R) MM represents a major challenge. In this trial, 17 R/R patients, who had previously experienced multiple lines treatments, received chimeric antigen receptor modified T (CAR T) cell preparation targeting two epitopes BCMA, and remarkable overall response 88.2% was achieved. This work confirms feasibility importance CAR therapy in...
Abstract Stat6 is known to drive macrophage M2 polarization. However, how polarization fine-tuned by poorly understood. Here, we find that Lys383 of acetylated the acetyltransferase CREB-binding protein (CBP) during activation suppress Mechanistically, Trim24, a CBP-associated E3 ligase, promotes acetylation catalyzing CBP ubiquitination at Lys119 facilitate recruitment Stat6. Loss Trim24 inhibits and thus in both mouse human macrophages, potentially compromising antitumor immune responses....
Abstract Metabolites from intestinal microbes modulate the mucosal immune system by regulating polarization and expansion of T cells. Whether microbial metabolites influence macrophage polarization, however, is poorly understood. Here, we show that large bowel fermentation product, butyrate, facilitates M2 in vitro vivo . The supernatant butyrate-treated increased migration enhanced wound closure rate MLE-12 Butyrate attenuated inflammation mice with dextran sulfate sodium (DSS)-induced...
Abnormal metabolism, including abnormal lipid is a hallmark of cancer cells. Some studies have demonstrated that the lipogenic pathway might promote development hepatocellular carcinoma (HCC). However, role lipolytic in HCC has not been elucidated. We compared levels adipose triglyceride lipase (ATGL) human and healthy liver tissues by real time PCR, western blot immunohistochemistry. measured diacylglycerol(DAG) free fatty acid (FFA) cells driven NEAT1-ATGL axis tissues. also assessed...
Metformin is a commonly used drug for the treatment of diabetes. Accumulating evidence suggests that it exerts anti-tumor effects in many cancers, including multiple myeloma (MM); however, underlying molecular mechanisms have not been clearly elucidated. The anti-myeloma metformin were evaluated using human MM cell lines (RPMI8226 and U266) vitro vivo NOD-SCID murine xenograft model. Cell viability was assessed with CCK8 proliferation measured by EdU incorporation assay. cycle distribution...
Histone 3 Lys27 (H3K27) trimethyltransferase Ezh2 is implicated in the pathogenesis of autoimmune inflammation. Nevertheless, role macrophage/microglial activation remains to be defined. In this study, we identified that H3K27me3 or Ezh2, rather than functioning as a repressor, mediates toll-like receptor (TLR)-induced proinflammatory gene expression, and therefore depletion diminishes attenuates inflammation dextran sulfate sodium–induced colitis experimental encephalomyelitis. Mechanistic...
Pathological cardiac hypertrophy is characterized by myocyte enlargement and dysfunction. However, the pathogenesis for this disease still poorly understood. Stimulator of interferon genes (STING) could meditate inflammation immune response in various kinds diseases. In work, we demonstrated that STING was critical pressure overload-induced hypertrophy. Results showed expression up-regulated human mouse hypertrophic hearts. knockout attenuated induced aortic banding (AB). The effects...
Abstract Background Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying effects remain unclear. Here, we studied A1 and their contribution murine Methods were induced by treatment with lipopolysaccharide (LPS) vitro. The functional phenotype was determined quantitative RT-PCR, ELISA, immunohistochemistry. To assess role vivo, mice injected intraperitoneally LPS. Then,...
Loss of phosphatase and tensin homolog (PTEN) activation the PI3K/AKT signaling pathway are hallmarks prostate cancer (PCa). However, these alterations alone insufficient for cells to acquire metastatic traits. Here, we have shown that histone dimethyl transferase WHSC1 critically drives indolent PTEN-null tumors become PCa. In a murine PCa model, overexpression in epithelium cooperated with Pten deletion produce metastasis-prone tumor. Conversely, genetic ablation Whsc1 prevented tumor...
Pathogenic factors driving obesity to type 2 diabetes (T2D) are not fully understood. Group 1 innate lymphoid cells (ILC1s) effectors of immunity and enriched in inflamed tissues. Here we show that the number adipose ILC1s increases obese T2D patients correlates with glycemic parameters blood; circulating ILC1 numbers decrease as a result metabolic improvements after bariatric surgery. In vitro co-culture experiments human promote fibrogenesis CD11c+ macrophage activation. Reconstruction...
Abstract For decades, great strides have been made in the field of immunometabolism. A plethora evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism center stage innate and adaptive immunomodulation. Given this, we focus changes immunometabolism, a converging series biochemical events that alters immune cell function, propose roles played by diversified metabolic derivatives enzymes, emphasize key metabolism-related checkpoints distinct...
Despite the encouraging outcome of chimeric antigen receptor T cell (CAR-T) targeting B maturation (BCMA) in managing relapsed or refractory multiple myeloma (RRMM) patients, therapeutic side effects and dysfunctions CAR-T cells have limited efficacy clinical application this promising approach. In study, we incorporated a short hairpin RNA cassette PD-1 into BCMA-CAR with an OX-40 costimulatory domain. The transduced PD-1KD BCMA were evaluated for surface CAR expression, T-cell...
Perturb-seq enabled the profiling of transcriptional effects genetic perturbations in single cells but lacks ability to examine impact on tissue environments. We present Perturb-DBiT for simultaneous co- sequencing spatial transcriptome and guide RNAs (gRNAs) same section vivo CRISPR screen with genome-scale gRNA libraries, offering a comprehensive understanding how modifications affect cellular behavior architecture. This platform supports variety delivery vectors, library sizes,...
Tumor virotherapy has been and continues to be used in clinical trials. One barrier effective viral oncolysis, consisting of the interferon (IFN) response induced by infection, is inhibited valproic acid (VPA) other histone deacetylase inhibitors (HDACi). Innate immune cell recruitment activation have shown deleterious efficacy oncolytic herpes simplex virus (oHSV) this report we demonstrate that VPA limits response. VPA, administered prior oHSV inoculation an orthotopic glioblastoma mouse...
Our previous studies demonstrated that volatile oil from saussurea lappa root (VOSL), rich in two natural sesquiterpene lactones, costunolide (Cos) and dehydrocostuslactone (Dehy), exerts better anti-breast cancer efficacy lower side effects than Cos or Dehy alone vivo, however, their anti-cancer molecular mechanisms were still unknown. In this study, we investigated the underlying of combination treatment (CD) on breast cells through proteomics technology coupled with Western blot...
Abstract Systemic lupus erythematosus (SLE) is characterized by uncontrolled secretion of autoantibodies plasma cells. Although the functional importance cells and in SLE has been well established, underlying molecular mechanisms controlling autoantibody production remain poorly understood. Here we show that Peli1 a B cell-intrinsic function to protect against lupus-like autoimmunity mice. deficiency induces via noncanonical NF-κB signaling. Mechanically, functions as an E3 ligase associate...
Type I interferon (IFN) is a critical pathogenic factor during the progression of lupus nephritis (LN). Although microRNAs (miRNAs) have been shown to control IFN response in immune cells LN, role miRNAs resident renal remains unclear. We undertook this study investigate microRNA-130b (miR-130b) pathway as well its therapeutic effect LN.Kidney tissues from patients and (NZB × NZW)F1 lupus-prone mice were collected for detecting miR-130b levels. Primary mesangial (RMCs) used determine...
Human papillomavirus (HPV) vaccine has been increasingly discussed in mainland China since its first approval 2016. To date, nearly all studies assessing HPV perceptions and attitudes were implemented during pre-licensure period. Therefore, the nationwide post-marketing survey was conducted to update knowledge, practice on among general population China.Participants aged 18-45 years living recruited April 2019 by multi-stage non-randomized sampling. Sociodemographic factors, related...
Abstract: Stimulator of interferon genes (STING1) is a key intermediary in activating the type I IFN response. STING-associated vasculopathy with onset infancy (SAVI) very rare autoinflammatory disease that caused by heterozygous gain-of-function mutations STING1. SAVI typically manifests as neonatal-onset systemic inflammation, interstitial lung (ILD), and severe cutaneous located acral regions, including fingers, toes, ears, nose. Severity ILD recurrent pulmonary infections are crucial for...