A5100669662- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Toxic Organic Pollutants Impact
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Immune Response and Inflammation
- Smoking Behavior and Cessation
- Immune cells in cancer
- Indoor Air Quality and Microbial Exposure
- Genomics, phytochemicals, and oxidative stress
- Phosphodiesterase function and regulation
- Epigenetics and DNA Methylation
- Postharvest Quality and Shelf Life Management
- Muscle Physiology and Disorders
- MicroRNA in disease regulation
- Receptor Mechanisms and Signaling
- Phytochemicals and Antioxidant Activities
- Inhalation and Respiratory Drug Delivery
- Phagocytosis and Immune Regulation
- Mesenchymal stem cell research
- Plant-derived Lignans Synthesis and Bioactivity
- Pluripotent Stem Cells Research
- Heat shock proteins research
Fudan University
2019-2025
Xinjiang Medical University
2024-2025
Minhang District Central Hospital
2020-2025
Chongqing Three Gorges University
2025
Chongqing University
2025
Yale University
2025
Tsinghua University
2021-2024
Tobacco Research Institute
2015-2024
Institute of Biophysics
2019-2024
Chinese Academy of Sciences
2019-2024
Protein kinase A (PKA) is a key regulatory enzyme that, on activation by cAMP, modulates wide variety of cellular functions. PKA isoforms type I and II possess different structural features biochemical characteristics, resulting in nonredundant function. However, how expressed the same cell manage to perform distinct functions soluble intracellular messenger, remains be established. Here, we provide mechanism for function subsets cardiac myocytes demonstrate that PKA-RI PKA-RII, binding...
Loss of phosphatase and tensin homolog (PTEN) activation the PI3K/AKT signaling pathway are hallmarks prostate cancer (PCa). However, these alterations alone insufficient for cells to acquire metastatic traits. Here, we have shown that histone dimethyl transferase WHSC1 critically drives indolent PTEN-null tumors become PCa. In a murine PCa model, overexpression in epithelium cooperated with Pten deletion produce metastasis-prone tumor. Conversely, genetic ablation Whsc1 prevented tumor...
The cAMP-specific phosphodiesterase PDE4D5 can interact with the signalling scaffold proteins RACK (receptors for activated C-kinase) 1 and β-arrestin. Two-hybrid co-immunoprecipitation analyses showed that RACK1 β-arrestin in a mutually exclusive manner. Overlay studies scanning peptide array libraries at overlapping sites within unique N-terminal region of distinct conserved PDE4 catalytic domain. Screening alanine substitution arrays, coupled mutagenesis truncation studies, allowed...
Autophagy is associated with secondary injury following traumatic brain (TBI) and expected to be a therapeutic target. Baicalin, neuroprotective agent, has been proven exert multi-functional bioactive effects in diseases. However, it unknown if Baicalin influences autophagy after TBI. In the present study, we aimed explore that had on TBI mice model, focusing as potential mechanism. We found administration significantly improved motor function, reduced cerebral edema, alleviated disruption...
Inflammatory bowel disease (IBD) is regarded as a kind of chronic and unspecific intestinal inflammatory disorder. Its exact pathogenesis has not been elucidated. Curcumin, an herbal drug, used in the treatment IBD due to its immunoregulation. Autophagy reported play important role mechanism IBD. In present study, we focused on autophagic regulation curcumin murine model dextran sulfate sodium (DSS)-induced colitis.We investigated effects progress DSS-induced acute colitis mice by evaluating...
The molecular and pathogenic mechanisms of esophageal squamous cell carcinoma (ESCC) development are still unclear, which hinders the effective treatments. In this study, we report that DUSP4 is highly expressed in human ESCC negatively correlated with patient prognosis. Knockdown suppresses proliferation patient-derived xenograft (PDX)-derived organoid (PDXO) growth inhibits cell-derived (CDX) development. Mechanistically, directly binds to heat shock protein isoform β (HSP90β) promotes...
There are several whole smoke exposure systems used to assess the biological and toxicological impact of tobacco in vitro. One such system is Vitrocell® VC 10 Smoking Robot module. Using quartz crystal microbalances (QCMs) installed into module, we were able particle deposition real-time. We compared regional across module positions doses delivered by six 10s four independent laboratories: two UK, one Germany China. Gauge R&r analysis was applied total data package from 10s. As a percentage...
Abstract Mechanical inputs give rise to p38 and JNK activation, which mediate adaptive physiological responses in various tissues. In skeletal muscle, contraction‐induced signaling ensure adaptation exercise, muscle repair, hypertrophy. However, the mechanisms by fibers sense mechanical load activate this have remained elusive. Here, we show that upstream MAP3K ZAKβ is activated cellular compression induced osmotic shock cyclic vitro , contraction vivo . This function relies on ZAKβ's...
The e-cigarette category is evolving rapidly, providing consumers with a variety of formats, ranging from cig-a-like products to larger, high-powered modular devices. When generating an in vitro assessment approach across such diverse products, dosimetry considerations are paramount. In this article, we have compared nicotine quantification techniques two studies using Vitrocell VC 10 Smoking Robot generate aerosols different e-cigarettes. Study 1, 3R4F reference cigarette and four...
Carbon nanoparticles entered cells <italic>via</italic> different endocytic pathways depending on the cell type.
Background . Papillary thyroid carcinoma (PTC) with central lymph node metastases (CLNMs) is common. The objective of this study was to investigate the incidence and risk factors metastasis patients PTC. Patients Methods Between January 2013 February 2015, a retrospective 543 PTC undergoing hemithyroidectomy or total thyroidectomy routine dissection (CLND) analyzed. Clinicopathologic for CLNM were studied using univariate multivariate analysis by SPSS 22.0 software. Results CLNMs in 38.1%...
Hyperglycemia, a key characteristic and risk factor for diabetes mellitus (DM), causes neuronal senescence. Hydrogen sulfide (H2S) is novel neuroprotectant. The present work was to investigate the potential effect of H2S on hyperglycemia-induced senescence underlying mechanisms. We found that NaHS, donor H2S, inhibited high glucose (HG)-induced cellular in HT22 cells (an immortalized mouse hippocampal cell line), as evidenced by decrease number SA-β-gal positive cells, increase growth,...