A5101726434- Plant Virus Research Studies
- Diabetes Management and Research
- Insect symbiosis and bacterial influences
- Diabetes Management and Education
- Vector-Borne Animal Diseases
- Aquaculture Nutrition and Growth
- Insect-Plant Interactions and Control
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Immune cells in cancer
- Herpesvirus Infections and Treatments
- Plant nutrient uptake and metabolism
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Liver Disease Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- Cytomegalovirus and herpesvirus research
- Customer Service Quality and Loyalty
- Autoimmune Neurological Disorders and Treatments
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
Yangzhou University
2008-2025
Tianjin Centers for Disease Control and Prevention
2024-2025
Minhang District Central Hospital
2025
Ningxia Medical University
2025
First Affiliated Hospital of Zhengzhou University
2023-2025
Fudan University
2025
Institute of Plant Protection
2024
Zhujiang Hospital
2024
Southern Medical University
1997-2024
Northwest A&F University
2018-2024
The identification of mechanisms to store glucose carbon in the form glycogen rather than fat hepatocytes has important implications for prevention nonalcoholic fatty liver disease (NAFLD) and other chronic metabolic diseases. In this work, we show that glycogenesis uses its intermediate metabolite uridine diphosphate (UDPG) antagonize lipogenesis, thus steering both mouse human toward storing as glycogen. underlying mechanism involves transport UDPG Golgi apparatus, where it binds site-1...
Akkermansia muciniphila (A. muciniphila), a gram-negative anaerobic bacterium, is selectively decreased in the fecal microbiota of patients with colorectal cancer (CRC), but its molecular mechanism CRC development remains inconclusive. In this study, we first confirmed inhibitory effect A. on formation and analyzed metabolic role intestinal flora human Polyps, A-CRA (advanced adenoma) samples. To better clarify development, pseudo-germ-free (GF) azoxymethane (AOM)/dextran sulfate sodium...
Aim To explore the relationship between spiritual climate and transformational leadership, examine their impact on nurses perceived emotional exhaustion intentions to quit. Background Transformational leadership is known have a significant positive effect work environment job satisfaction. Additionally, promoting amongst staff can benefit workers by increasing self-worth. The two unknown. Methods Nurse clinicians from 2 sites in Jiangsu Province of China completed self-report questionnaires...
The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations SARS-CoV-2 among patients within across households. Our work showed an active replication activity in respiratory tract co-existence genetically distinct viruses same host. inter-host comparison further revealed narrow transmission bottleneck between from households, suggesting dominated role stochastic dynamics...
To explore the autoimmune response and outcome in central nervous system (CNS) at onset of viral infection correlation between autoantibodies viruses. Methods A retrospective observational study was conducted 121 patients (2016–2021) with a CNS confirmed via cerebrospinal fluid (CSF) next-generation sequencing (cohort A). Their clinical information analysed CSF samples were screened for against monkey cerebellum by tissue-based assay. In situ hybridisation used to detect Epstein-Barr virus...
Abstract Avian hepatitis E virus (HEV) has been identified in chickens; however, only 4 complete or near-complete genomic sequences have reported. We found that the sequence of avian HEV chickens from China shared highest identity (98.3%) with Europe and belonged to genotype 3.
Recently, the global supply shortage of fish oil (FO) has resulted in rapid price increases, and aquatic feed is largest consumption FO. Black soldier fly larvae (Hermetia illucens) (HIO) rich lauric acid been suggested as a possible source lipids for diet. The current study aims to evaluate whether it feasible replace FO Pacific white shrimp (Litopenaeus vannamei) (4.95 ± 0.10 g) with HIO investigate effects this substitution on growth, biochemical indices, approximately composition,...
Emerging evidence highlights the potential impact of intratumoral microbiota on cancer. However, microbial composition and function in glioma remains elusive. Consequently, our study aimed to investigate community tissues elucidate its role development. We parallelly performed profiling, transcriptome sequencing, metabolomics detection tumor adjacent normal brain obtained from 50 patients. employed immunohistochemistry, multicolor immunofluorescence, fluorescence
Viruses are encapsidated mobile genetic elements that rely on host cells for replication. Several cytoplasmic RNA viruses synthesize proteins and/or RNAs translocate to infected cell nuclei. However, the underlying mechanisms and role(s) of cytoplasmic—nuclear trafficking unclear. We demonstrate infection small brown planthoppers with rice stripe virus (RSV), a negarnaviricot virus, results in K63-linked polyubiquitylation RSV’s nonstructural protein 3 (NS3) at residue K127 by RING ubiquitin...
Abstract Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases and associated with Alzheimer's (AD). Both docosahexaenoic acid (DHA) medium chain triglycerides (MCTs) play essential roles in lipid metabolism inhibition amyloid‐β (Aβ) accumulation. We aimed to explore possible association between cerebral Aβ deposition development NAFLD investigate effect DHA combined MCTs on delaying progression To this end, 40 three‐month‐old APP/PS1 male mice were randomly...
Glial fibrillary acidic protein-immunoglobulin G (GFAP-IgG) positivity is associated with autoimmune GFAP astrocytopathy (GFAP-A), but also other encephalitides and viral infections. We attempted to elucidate the characteristics of GFAP-A in relation GFAP-IgG-positive constructed a differential diagnosis model. 141 cases were identified, including 52 (GFAP-A group), 48 encephalitis (AE-G), 41 (VE-G). Multivariate logistic regression was employed create diagnostic model, validation using an...
Chitin deacetylase modifies chitin and has critical functions in the growth development of insects; however, whether it other roles is unclear. Laodelphax striatellus not only directly feeds on phloem sap rice but also transmits RSV, leading to significant losses production. In this study, four CDA genes were identified based SBPH genomic data classified into groups I III a phylogenetic analysis. The expression LsCDA1 LsCDA2 RSV-infected was increased by 282% 159%, respectively, relative...
Abstract Objective The incidence of Type 2 Diabetes Mellitus (T2DM) continues to rise steadily, significantly impacting human health. Early prediction pre-diabetic risks has emerged as a crucial public health concern in recent years. Machine learning methods have proven effective enhancing accuracy. However, existing approaches may lack interpretability regarding underlying mechanisms. Therefore, we aim employ an interpretable machine approach utilizing nationwide cross-sectional data...
Rice stripe virus (RSV, genus Tenuivirus, family Phenuiviridae) is the causal agent of rice disease transmitted by small brown planthopper (SBPH, Laodelphax striatellus) in a persistent propagative manner. The midgut and salivary glands SBPH are first last barriers to viral circulation transmission processes, respectively; however, precise mechanisms used RSV cross these organs transmit plants have not been fully elucidated. We obtained full-length cDNA sequence L. striatellus α-tubulin 2...
Abstract Aim The study aimed to explore the association between diabetes‐related distress as a dependent variable and fear of hypoglycaemia independent in Chinese individuals with type 2 diabetes, which can provide basis for development effective nursing interventions. Design A cross‐sectional descriptive study. Methods Pre‐piloted scales were used determine whether they experienced this impacted upon their management disease. From June–October 2019, participants asked complete...
To investigate the factors that influence health literacy (HL) among Chinese patients with rheumatoid arthritis (RA) and furnish theoretical underpinnings for development of intervention strategies aimed at enhancing patients' quality life.