A5100430241- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Lung Cancer Treatments and Mutations
- Coronary Interventions and Diagnostics
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Acute Myocardial Infarction Research
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Medical Imaging Techniques and Applications
- Acute Kidney Injury Research
- Cardiovascular Function and Risk Factors
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Research and Treatments
- Head and Neck Cancer Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced MRI Techniques and Applications
- Colorectal Cancer Treatments and Studies
Tianjin Chest Hospital
2016-2025
Peking University First Hospital
2014-2025
Peking University
2008-2025
Tongji Hospital
2022-2025
Huazhong University of Science and Technology
2022-2025
Henan University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
West China Hospital of Sichuan University
2019-2025
Takeda (United States)
2020-2025
University of Rochester
2014-2025
Since the beginning of 2020, coronavirus disease 2019 (COVID-19) has spread throughout China. This study explains findings from lung computed tomography images some patients with COVID-19 treated in this medical institution and discusses difference between other diseases.
Perirectal spacing, whereby biomaterials are placed between the prostate and rectum, shows promise in reducing rectal dose during cancer radiation therapy. A prospective multicenter randomized controlled pivotal trial was performed to assess outcomes following absorbable spacer (SpaceOAR system) implantation.Overall, 222 patients with clinical stage T1 or T2 underwent computed tomography (CT) magnetic resonance imaging (MRI) scans for treatment planning, followed fiducial marker placement,...
<h3>Background</h3> PD-1/PD-L1 blockade has received approval for clinical application due to its encouraging benefit with improving prognosis in selected populations. Unfortunately, the response immunotherapy many patients remains unsatisfactory. It a great challenge generate potential combinations that will outperform single agents alone regard anti-tumor activity. <h3>Methods</h3> Using NSCLC cell lines and mouse models, we explored effects of combined niclosamide PD-L1 on tumor growth T...
SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target. However, role of in cancer not fully understood. Herein we describe generation inducible Sod1 knockout KRAS-driven NSCLC mouse model. markedly reduces tumor burden vivo blocks growth KRAS mutant cells vitro. Intriguingly, enriched nucleus notably nucleolus cells. The nuclear nucleolar, cytoplasmic, form essential for lung cell proliferation. Moreover, interacts with PeBoW complex controls its assembly...
The present study was designed to investigate the protective effect of betulinic acid (BA) on streptozotocin (STZ)-induced diabetic rats.
Background: Recent studies have demonstrated the tremendous potential of epicardial fat volume (EFV) to predict obstructive coronary artery disease. We aimed develop a new model estimate pretest probability disease using traditional risk factors with calcium score and EFV compare it proposed models in Chinese patients who underwent computed tomography angiography. Methods: The were derived from 5743 consecutive multivariate logistic regression validated an internal cohort invasive...
N6-methyladenosine (m6A) RNA methylation, the most prevalent internal chemical modification of mRNA, has been reported to participate in progression various tumours via dynamic regulation m6A methylation regulators. However, role regulators chronic obstructive pulmonary disease (COPD) never reported. This study aimed determine expression and potential functions COPD. Four gene data sets were acquired from Gene Expression Omnibus. ontology function, Kyoto Encyclopedia Genes Genomes pathway...
Abstract Purpose: A major challenge in platinum-based cancer therapy is the clinical management of chemoresistant tumors, which have a largely unknown pathogenesis at level epigenetic regulation. Experimental Design: We evaluated potential using global loss 5-hydroxymethylcytosine (5-hmC) levels as novel diagnostic and prognostic marker to better assess chemotherapy response outcome high-grade serous tumors (HGSOC), most common deadliest subtype ovarian cancer. Furthermore, we identified...
We aimed to identify imaging biomarkers assess predictive capacity of radiomics nomogram regarding treatment response status (responder/non-responder) in patients with advanced NSCLC undergoing anti-PD1 immunotherapy.197 eligible histologically confirmed were retrospectively enrolled from nine hospitals. carried out a characterization target lesions (TL) approach and largest lesion (LL) on baseline first follow-up (TP1) CT data. Delta-radiomics feature was calculated as the relative net...
Doxorubicin (DOX) is one of the most commonly used antineoplastic agents; however, its considerable nephrotoxicity restricts clinical use. Kaempferol (KPF), a naturally-occurring flavonoid, possesses various biological benefits, including anti-tumor activity that has garnered increasing attention. This study aimed to evaluate possible reno-protective role KPF in DOX nephrotoxicity. Male BALB/c mice were injected with via tail vein imitate renal damage. Their body and kidney weighed after 2...
To report our institutional experience with five fractions of daily 8-12 Gy stereotactic body radiotherapy (SBRT) for the treatment oligometastatic cancer to lung.Thirty-four consecutive patients cancers lung were treated image-guided SBRT between 2008 and 2011. Patient age ranged from 38 81 years. There 17 males females. Lung metastases following primary types: colon (n=13 patients), head neck (n=6), breast (n=4), melanoma sarcoma (n=4) renal cell carcinoma (n=3). The median prescription...
In lung cancers with low expression of C/EBPα, BMI1 correlates worse prognosis but can be targeted a drug.