A5100772614- Colorectal Cancer Treatments and Studies
- Immunotherapy and Immune Responses
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- Animal Virus Infections Studies
- Computational Drug Discovery Methods
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Cancer Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and preeclampsia studies
- Tea Polyphenols and Effects
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Viral Infections and Vectors
- Protease and Inhibitor Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
Wuhan University
2017-2025
Hunan Academy of Agricultural Sciences
2023-2025
Liaoning University of Traditional Chinese Medicine
2023-2025
Duke University
2005-2025
Tea Research Institute
2023-2025
Peking Union Medical College Hospital
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
The People's Hospital of Guangxi Zhuang Autonomous Region
2023-2025
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2024-2025
Beijing Proteome Research Center
2020-2025
Abstract Background N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulation in eukaryotic cells. However, understanding of m6A colorectal cancer (CRC) very limited. We designed this study to investigate role CRC. Methods Expression level METTL14 was extracted from public database and tissue array clinical relevance Next, gain/loss function experiment used define progression Moreover, transcriptomic sequencing (RNA-seq) applied screen potential targets METTL14. The specific...
Wnt/β-catenin pathway activation caused by adenomatous polyposis coli (APC) mutations occurs in approximately 80% of sporadic colorectal cancers (CRC). The antihelminth compound niclosamide downregulates components the Wnt pathway, specifically Dishevelled-2 (Dvl2) expression, resulting diminished downstream β-catenin signaling. In this study, we determined whether could inhibit human CRCs and its inhibition might elicit antitumor effects presence APC mutations. We found that inhibited...
Ferroptosis, a new type of cell death has been found to aggravate intestinal ischemia/reperfusion (I/R) injury. However, little is known about the changes gut microbiota and metabolites in I/R role on ferroptosis-induced This study aimed establish mouse model ileum organoid hypoxia/reoxygenation (H/R) explore during protective ability capsiate (CAT) against ferroptosis-dependent Intestinal induced disturbance significant metabolites. We that CAT metabolite levels preoperative stool patients...
Intestinal ischemia/reperfusion (I/R) injury has high morbidity and mortality rates. Gut microbiota is a potential key factor affecting intestinal I/R injury. Populations exhibit different sensitivities to injury; however, whether this interpopulation difference related variation in gut unclear. Here, elucidate the interaction between microbiome injury, we performed 16S DNA sequencing on preoperative feces of C57BL/6 mice fecal transplantation (FMT) experiments germ-free mice. The transwell...
The angiotensin-converting enzyme 2 (ACE2) receptor is shared by various coronaviruses with distinct receptor-binding domain (RBD) architectures, yet our understanding of these convergent acquisition events remains elusive. Here, we report that two bat MERS-related (MERSr-CoVs) infecting Pipistrellus nathusii (P.nat)-MOW15-22 and PnNL2018B-use ACE2 as their receptor, narrow ortholog specificity. Cryoelectron microscopy structures the MOW15-22/PnNL2018B RBD-ACE2 complexes unveil an unexpected...
Abstract Background High intensity focused ultrasound (HIFU) is an emerging non-invasive treatment modality for localized of cancers. While current clinical strategies employ HIFU exclusively thermal ablation the target sites, biological responses associated with both and mechanical damage from have not been thoroughly investigated. In particular, endogenous danger signals HIFU-damaged tumor cells may trigger activation dendritic cells. This response play a critical role in HIFU-elicited...
The HER2-specific monoclonal antibody (mAb), trastuzumab, has been the mainstay of therapy for HER2+ breast cancer (BC) approximately 20 years. However, its therapeutic mechanism action (MOA) remains unclear, with antitumor responses to trastuzumab remaining heterogeneous and metastatic BC incurable. Consequently, understanding MOA could enable rational strategies enhance efficacy. Using both murine human versions we found activity dependent on Fcγ receptor stimulation tumor-associated...
Despite multimodal adjuvant management with radiotherapy, chemotherapy and hormonal therapies, most surgically resected primary breast cancers relapse or metastasize. A potential solution to late distant recurrence is augment systemic antitumor immunity, in part by appropriately presenting tumor antigens, but also modulating the immunosuppressive microenvironment (TME). We previously validated this concept models of murine carcinoma treated a novel predominately microcavitating version...
Electrocatalytic carbon dioxide reduction reaction (CO
This study aimed to develop a new ultrasonographic dating formula estimate gestational age (GA) based on fetal crown–rump length (CRL) in Chinese population, evaluate model accuracy and compare its performance with established formulas. A prospective, multicenter was conducted across mainland China. Participants included healthy, low-risk women spontaneously conceived singleton pregnancies regular menstrual cycle the preceding year. Ultrasonography performed between 11 14 weeks of gestation,...
Dipeptidyl peptidase-4 (DPP4) is a well-established receptor for several MERS-related coronaviruses (MERSr-CoVs) isolated from humans, camels, pangolins, and bats. However, the usage of many genetically diverse bat MERSr-CoVs with broad geographical distributions remains poorly understood. Recent studies have identified angiotensin-converting enzyme 2 (ACE2) as an entry multiple merbecovirus clades. Here, using viral antigen pseudovirus-based functional assays, we demonstrate that...
Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) targeting HER2, exhibiting significant clinical efficacy in breast cancer (BC) with varying HER2 expression, including HER2-low and HER2-ultralow. However, the precise mechanism underlying its contribution of immune activation these settings remain unclear. Here, we demonstrate that T-DXd HER2-negative BC independent engagement ADC internalization. Instead, activity relies on extracellular proteases, such as cathepsin L...
ABSTRACT Nearly 50 years ago, the discovery of interferon prompted notion that host cells innately respond to viral invasion. Since time, technological advances have allowed this response be extensively characterized and dissected in vitro. However, these only recently been applied highly complex, vivo biological systems. To end, we exploited high-titer adenovirus (Ad) vectors globally investigate innate immune nonenveloped infection vivo. Our results indicated a potent cellular...
N6-methyladenosine (m6A) RNA methylation, the most prevalent internal chemical modification of mRNA, has been reported to participate in progression various tumours via dynamic regulation m6A methylation regulators. However, role regulators chronic obstructive pulmonary disease (COPD) never reported. This study aimed determine expression and potential functions COPD. Four gene data sets were acquired from Gene Expression Omnibus. ontology function, Kyoto Encyclopedia Genes Genomes pathway...
Triple-negative breast cancer (TNBC) is an aggressive and molecularly diverse subtype typified by the presence of p53 mutations (∼80%), elevated immune gene signatures neoantigen expression, as well tumor infiltrating lymphocytes (TILs). As these factors are hypothesized to be strong immunologic prerequisites for use checkpoint blockade (ICB) antibodies, multiple clinical trials testing single ICBs have advanced Phase III, with early indications heterogeneous response rates <20% anti-PD1...
ObjectivesTo explore the relationship between psychosocial support related factors and mental health of COVID-19 positive patients.MethodsThis exploratory study 35 patients were enrolled February 1 to March 1, 2020. Sleep quality, depression, anxiety, social measured data participants collected. Psychological intervention was administered followed two weeks post intervention. Linear regression performed risk improvement psychological symptoms.FindingsThirty-two individuals exhibited sleep,...
Two HER2-specific mAbs, trastuzumab and pertuzumab (T+P), combined with chemotherapy comprise standard-of-care treatment for advanced HER2+ breast cancers (BC). While this antibody combination is highly effective, its synergistic mechanism-of-action (MOA) remains incompletely understood. Past studies have suggested that the synergy underlying occurs through different mechanisms elicited by these antibodies, suppressing HER2 heterodimerization inducing antitumor immunity. However, in vivo...