A5053281055- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Advanced MRI Techniques and Applications
- Treatment of Major Depression
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- MicroRNA in disease regulation
- Cognitive Abilities and Testing
- Obsessive-Compulsive Spectrum Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Substance Abuse Treatment and Outcomes
- Autism Spectrum Disorder Research
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Attention Deficit Hyperactivity Disorder
- COVID-19 and Mental Health
West China Hospital of Sichuan University
2016-2025
Sichuan University
2016-2025
Wenzhou Medical University
2024-2025
Ningxia University
2025
Huazhong University of Science and Technology
2023-2025
Tongji Hospital
2023-2025
Qingdao University
2025
Yuhuangding Hospital
2025
Guangxi Medical University
2025
Shanghai Jiao Tong University
2024
The purpose of this study was to determine the brain regions associated with anosognosia in Alzheimer's disease (AD). Anosognosia for memory disturbance assessed 29 probable AD patients, based on discrepancy between questionnaire scores patients and their caregivers. In I-123-IMP single photon emission computed tomography (SPECT), a significant association found decreased perfusion orbitofrontal cortex, using regression analysis. This result is consistent previous studies that have reported...
Autophagy consists of lysosome-dependent degradation cytoplasmic contents sequestered by autophagic vesicles (AV). The role autophagy in determining tumor aggressiveness and response to therapy melanoma was investigated this study.Autophagy measured biopsies obtained from metastatic patients enrolled on a phase II trial temozolomide sorafenib correlated clinical outcome. These results were compared with measurements aggressive indolent cells grown two- three-dimensional (3D) culture as...
Abstract Depression is a common psychiatric disorder, and monoamine‐based antidepressants as first‐line therapy remain ineffective in some patients. The synergistic modulation of neuroinflammation neuroplasticity could be major strategy for treating depression. In this study, an inflammation‐targeted microglial biomimetic system, PDA‐Mem@M, reported Microglial membrane‐coated nanoparticles penetrate the blood‐brain barrier facilitate targeting. Subsequently, owing to excellent free...
The purpose of the present study was to characterize association between clinical symptoms and anatomical functional cerebral deficits in a relatively large sample antipsychotic-naive first-episode schizophrenia patients using optimized voxel-based morphometry resting state connectivity analysis.Participants were 68 matched healthy comparison subjects. Both subjects scanned volumetric three-dimensional spoiled gradient recall sequence gradient-echo echo-planar imaging sequence....
Wernicke's concept of 'sejunction' or aberrant associations among specialized brain regions is one the earliest hypotheses attempting to explain myriad symptoms in psychotic disorders. Unbiased data mining all possible brain-wide connections large sets an essential first step localizing these circuits.
Major depressive disorder (MDD) is a complex mood characterized by persistent and overwhelming depression. Previous studies have identified abnormalities in large scale functional brain networks MDD, yet most of them were based on static connectivity. In contrast, here we explored disrupted topological organization dynamic network connectivity (dFNC) MDD graph theory. 182 patients 218 healthy controls included this study, all Chinese Han people. By applying group information guided...
Background Given the important role of default mode network (DMN) in cognitive function and well-known neurocognitive deficit schizophrenia, it is intriguing to examine systematically relationship between dysfunction aberrant intrinsic activities, also functional connectivity, DMN patients with schizophrenia. Method First-episode, treatment-naive schizophrenia (FES) ( n = 115) healthy controls 113) underwent resting-state magnetic resonance imaging (fMRI) scans tests. Intrinsic neural...
Major depressive disorder (MDD) is heterogeneous associated with aberrant functional connectivity within the default mode network (DMN). This study focused on data-driven identification and validation of potential DMN-pattern-based MDD subtypes to parse heterogeneity disorder. The sample comprised 1397 participants including 690 patients 707 healthy controls (HC) registered from multiple sites based REST-meta-MDD Project in China. Baseline resting-state magnetic resonance imaging (rs-fMRI)...
Diarrhea is a prevalent disease among calves, which significantly hinders their growth and development, thereby impacting farm productivity revenue. This study aimed to investigate the impact of diarrhea on calf growth. Holstein male calves with similar birth weight (39.5 ± 4.2 kg) were included in this study, key parameters such as fecal score, incidence, performance from weaning measured. Rectal samples both diarrheic (n = 24) healthy aged 1-4 weeks analyzed using 16S rRNA gene sequencing...
Background It is not clear whether the progressive changes in brain microstructural deficits documented previous longitudinal magnetic resonance imaging (MRI) studies might be due to disease process or other factors such as medication. important explore alterations white-matter (WM) microstructure antipsychotic-naive patients with first-episode schizophrenia during very early phase of treatment when relatively ‘free’ from chronicity. Method Thirty-five and 22 healthy volunteers were...
There is compelling evidence that epigenetic factors contribute to the manifestation of depression, in which microRNA132 (miR-132) suggested play a pivotal role pathogenesis and neuronal mechanisms underlying symptoms depression. Additionally, several depression-associated genes [MECP2, ARHGAP32 (p250GAP), CREB, period genes] were experimentally validated as miR-132 targets. However, most studies regarding major depressive disorder are based on post-mortem, animal models or genetic...
The dopamine hypothesis is one of the most influential theories neurobiological background schizophrenia (SCZ). However, direct evidence for abnormal dopamine-related subcortical-cortical circuitry disconnectivity still lacking. aim this study was therefore to test substantia nigra (SN)-based striato-thalamo-cortical resting-state functional connectivity (FC) in SCZ. Based on our a priori hypothesis, we analyzed large sample magnetic resonance imaging (fMRI) dataset from first-episode...
Depression in bipolar disorder (BipD) requires a therapeutic approach that is from treating unipolar major depressive (UniD), but to date, no reliable methods could separate these two disorders. The aim of this study was establish the clinical validity and utility non-invasive functional MRI-based method classify BipD UniD.The degree connectivity (degree centrality or DC) every small unit (voxel) with other brain estimated 22 patients age, gender, severity-matched UniD healthy controls....
Background Internet addiction has become a major global concern and burden on mental health. However, there is lack of consensus its link to health outcomes. Objective The aim this study was investigate the associations between internet severity adverse Methods First-year undergraduates enrolled at Sichuan University during September 2015, 2016, 2017, 2018 were invited participate in current survey, 85.13% (31,659/37,187) whom fully responded. Young’s 20-item Addiction Test, Patient Health...
ObjectivesTo explore the relationship between psychosocial support related factors and mental health of COVID-19 positive patients.MethodsThis exploratory study 35 patients were enrolled February 1 to March 1, 2020. Sleep quality, depression, anxiety, social measured data participants collected. Psychological intervention was administered followed two weeks post intervention. Linear regression performed risk improvement psychological symptoms.FindingsThirty-two individuals exhibited sleep,...
Parkinson's disease (PD) is the most common chronic neurodegenerative and characterized by motor dysfunctions. Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are a major cause of neurotoxicity that causes PD. As an inhibitor LRRK2 activity, vitamin B12 (VB12) promising therapeutic option for PD shown to restore autophagy models. However, dependence on transporters extremely low brain tissue utilization VB12 limit its effects. Based this, VB12-loaded tetrahedral framework...