A5100561135- Mental Health Treatment and Access
- Gut microbiota and health
- Mental Health Research Topics
- Tryptophan and brain disorders
- Phytoestrogen effects and research
- Child and Adolescent Psychosocial and Emotional Development
- Phytochemicals and Medicinal Plants
- Posttraumatic Stress Disorder Research
- Health disparities and outcomes
- Seaweed-derived Bioactive Compounds
- Homelessness and Social Issues
- Polysaccharides and Plant Cell Walls
- Suicide and Self-Harm Studies
- Food Quality and Safety Studies
- Schizophrenia research and treatment
- Stress Responses and Cortisol
- Liver Disease Diagnosis and Treatment
- Health, Environment, Cognitive Aging
- Pharmacological Effects of Medicinal Plants
- Imbalanced Data Classification Techniques
- Advanced Glycation End Products research
- Mental Health and Psychiatry
- Optimal Experimental Design Methods
- Child Abuse and Trauma
- Clostridium difficile and Clostridium perfringens research
Wannan Medical College
2024-2025
Sichuan University
2020-2025
West China Hospital of Sichuan University
2020-2025
Centre for Mental Health
2024
Guilin University of Technology
2023
Guangxi University
2023
Nanjing Normal University
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Recent studies have associated immune abnormalities with dementia. IL-6 is a crucial cytokine in inflammatory responses, and recent evidence has linked elevated levels to changes brain structure cognitive decline. However, the connection between levels, cognition, volumes, dementia risk requires exploration large prospective cohorts.
Rising studies have consistently reported gut bacteriome alterations in schizophrenia (SCZ). However, little is known about the role of virome on shaping SCZ. Here in, we sequenced fecal virome, bacteriome, and host peripheral metabolome 49 SCZ patients health controls (HCs). We compared bacterial community composition specific abundant bacteria HCs. Specific viruses metabolites co-occurring with differential were identified using Multiple Co-inertia Analysis (MCIA). Additionally, construct...
As widely used in traditional Chinese medicine and nutritional food, Polygonati Rhizom is known for its diverse pharmacological properties, including hematopoiesis, immune enhancement, antitumor, anti‐inflammatory, antioxidant, antiaging, antiviral, hepatoprotection. polysaccharides (PRPs) are primary bioactive compounds that water‐soluble mainly comprise fructose (Fru), glucose (Glc), galactose (Gal), arabinose (Ara), rhamnose (Rha), fucose (Fuc), xylose (Xyl), glucuronic acid (GlcA),...
Suicide is one of the leading causes death for college students. The predictors suicidal ideation among students are inconsistent and few studies have systematically investigated psychological symptoms to predict suicide. Therefore, this study aims develop a prediction model explore important in China.We recruited 1,500 Sichuan University followed up 4 years. Demographic information, behavioral information participants were collected using computer-based questionnaires. Radial Basis Function...
Pyrrosiae Folium (PF) is a commonly used Chinese herb medicine originating from three Pyrrosia species for the treatment of urinary infection and urolithiasis. According to practice, different specie origins led some variations in therapeutic effects PF. To ensure safety efficacy PF clinical it necessary establish reliable integrative method distinguish occurring species. In present paper, HPLC–DAD was developed applied simultaneously analyze five major compounds Afterwards, multivariate...
Abstract Background Posttraumatic stress disorder (PTSD) is the most prevalent type of psychiatric among children after an earthquake. This study investigated role trauma experiences, personality traits, and genotype in maintenance PTSD symptoms. Methods In a previous large-scale epidemiological investigation 1 year Wenchuan earthquake, 215 with symptoms were selected at random their blood samples collected. All them followed up, assessed 3 years later. The adolescent version UCLA Reaction...
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It is widely acknowledged that childhood adversities (CAs) and recent stress are potential risk factors for adult depression. However, the mechanism(s) by which interactions of CAs with affect depression remain unclear.To investigate predictive association interaction among early-adult depression.We conducted an annual survey all freshmen period 2016-2018 in a Chinese comprehensive university, sample size 23,206. An online questionnaire including standardized self-report instruments was used...
Abstract Background Residential mobility during childhood increases risk of psychopathology in adulthood and is a common experience among Chinese children. This study investigated associations between number age first move, etiological factors for psychopathology, mental disorders adolescence early adulthood. Methods The sample included 39,531 undergraduates (84.5% completion rate) 15–34 years their year at comprehensive university annual cross-sectional surveys 2014–2018. Common measured...
Abstract Background Urban birth and upbringing show consistent associations with psychotic illness but the key urban exposures remain unknown. Associations psychotic-like experiences (PEs) are inconsistent. These could be confounded by common mental disorders associated PEs. Furthermore, between PEs may not extrapolate to such as schizophrenia. Methods Annual cross-sectional surveys among first year Chinese undergraduates 2014–2019 ( n = 47,004). Self-reported, hierarchical categorisation of...
<title>Abstract</title> Background The rate of suicidality and non-suicidal self-injury (NSSI) among youth has been rising. Previous studies have shown adverse childhood experiences (ACEs) are risk factors for psychological issues children exposed to ACEs more sensitive discrimination. This study investigates the relationship between NSSI in adolescents, with a specific focus on sequential mediating roles perceived sexual orientation discrimination anhedonia. Methods We included 11,880 aged...
<title>Abstract</title> Rising studies have consistently reported gut bacteriome alterations in schizophrenia (SCZ). However, little is known about the role of virome on shaping SCZ. Here in, we sequenced fecal virome, bacteriome, and host peripheral metabolome 49 SCZ patients health controls (HCs). We compared bacterial community composition specific abundant bacteria HCs. Specific viruses metabolites co-occurring with differential were identified using Multiple co-inertia analysis (MCIA)....
Radix Pueraria lobata has been recognized as a medicine and functional food, whose polysaccharide is its main bioactive component. In this study, we employed the response surface method to optimize extraction of from Puerariae lobatae (PLP). Based on single-factor experiment, three levels liquid–material ratio, time, temperature were selected for experiment. We established quadratic regression equation rate. The optimal combination conditions obtained through analysis ridge analysis. yield...
Radix Puerariae lobatae polysaccharide (PLP1, M w = 10.43 kDa), a novel isolated in our previous studies, possesses remarkable hepatoprotective properties. In this study, highly sensitive fluorescent probe, namely, PLP1‐tyrosine (TYR)‐fluorescein isothiocyanate (FITC), was developed to investigate the distribution of PLP1 vitro and vivo . The probe characterized using fluorescence, high‐performance gel permeation chromatography, infrared spectroscopy, ultraviolet nuclear magnetic resonance...
Purpose University students experience high levels of stress, and the prevalence depression is higher than in general population. The reason not clear. More effective interventions better prevention are needed. Methods We did annual cross-sectional surveys Chinese undergraduates 2014–2018 (mean age 18.7 [SD 2.1], N = 39,573). measured adaptation to university life using Adolescent Self-rating Life Events Checklist (ASLEC) common mental disorders standardized self-report instruments....
Abstract Background It is unclear whether psychotic experiences (PEs) gradually merge into states of clinical psychosis along a continuum which correspond to dimensional classification or latent classes appear above certain severity threshold better diagnostic categories psychosis. Methods Annual cross-sectional surveys, 2014–19, among Chinese undergraduates ( N = 47,004) measured PEs, depression and etiological risk factors using standardized self-report instruments. We created with five...
Active learning focuses on selecting a small subset of the most valuable instances for labeling to learn highly accurate model. Considering informativeness and representativeness unlabeled is significant query, some works have been done about combing criteria. However, them are generally in fixed manner balance these criteria, difficult find suitable sampling strategies weights various datasets. In this paper, an adaptive active method ALIR proposed address limitations. Firstly, framework...
Abstract Purpose The stressful global situation due to the COVID-19 pandemic has had a tremendous impact on mental health in hospitalized patients with schizophrenia. mediating roles of psychological impacts related sleep quality and emotional distress were investigated association between childhood trauma suicide risk inpatients Methods A total 270 participants, including 125 in-patients schizophrenia 145 healthy controls (HCs) enrolled. Childhood trauma, COVID-19, quality, measured using...