A5012739154- RNA modifications and cancer
- Phytoestrogen effects and research
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Advanced Glycation End Products research
- Liver physiology and pathology
- Inflammatory Biomarkers in Disease Prognosis
- NF-κB Signaling Pathways
- Food Quality and Safety Studies
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Natural product bioactivities and synthesis
- Liver Disease Diagnosis and Treatment
- Plant-Microbe Interactions and Immunity
- Alcohol Consumption and Health Effects
- Natural Products and Biological Research
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Single-cell and spatial transcriptomics
- Ovarian cancer diagnosis and treatment
- Tryptophan and brain disorders
Wannan Medical College
2023-2025
Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2023-2025
Nanjing Medical University
2025
Taizhou People's Hospital
2021-2025
Nantong University
2012-2025
China Agricultural University
2025
Hunan University of Traditional Chinese Medicine
2025
First Affiliated Hospital of Xi'an Jiaotong University
2022
Second Hospital of Hebei Medical University
2021
Hebei Medical University
2021
The aim of this study was to explore the anti-tumor effect and therapeutic potential rosmarinic acid (RA) in treatment hepatocellular carcinoma (HCC). RA at 75, 150 300 mg/kg given H22 tumor-bearing mice by intragastric administration once daily for 10 consecutive days. Levels inflammatory angiogenic factors, including interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), transforming factor-β (TGF-β) were measured enzyme...
Abstract Dendritic cells (DCs) are the most potent antigen-presenting with multifaceted functions in controlling immune activation and tolerance. Graves' disease, particularly ophthalmopathy, is recognized as a refractory autoimmune thyroid disease. Therefore, DC-targeted therapies aimed at inducing specific tolerance important for treatment of we utilized polylactic acid glycolic polymer (PLGA) nanoparticles encapsulating disease auto-antigen thyrotropin receptor A (TSHR-A) peptide inducer...
Osteoarthritis (OA), one of the most common motor system disorders, is a degenerative disease involving progressive joint destruction caused by variety factors. At present, OA has become fourth cause disability in world. However, pathogenesis complex and not yet been clarified. Long non-coding RNA (lncRNA) refers to group RNAs more than 200 nucleotides length with limited protein-coding potential, which have wide range biological functions including regulating transcriptional patterns...
Abstract Infection by the fungal pathogen Magnaporthe oryzae elicits dynamic responses in rice. Utilizing an integrated approach of single‐cell and spatial transcriptomics, a 3D response is uncovered within rice leaf cells to M. infection. A comprehensive atlas constructed from 236 708 transcriptomes, revealing heightened expression immune receptors, namely Pattern Recognition Receptors (PRRs) Nucleotide‐binding site leucine‐rich repeat (NLRs) proteins, vascular tissues. Diterpene...
This study aims to investigate the protective effects and mechanisms of polysaccharide extract PCP1 from Polygonatum cyrtonema in ameliorating cerebral ischemia-reperfusion(I/R) injury rats through modulation Toll-like receptor 4(TLR4)/NOD-like protein 3(NLRP3) signaling pathway. In vivo, SD were randomly divided into sham group, model nimodipine(NMDP) TLR4 inhibitor(TAK-242) group. A middle artery occlusion/reperfusion(MCAO/R) was established, neurological deficit scores infarct size...
In eukaryotes, histones and their variants are essential for chromatin structure function; both play important roles in the regulation of gene transcription, as well development tumors. We aimed to explore genomics data hepatocellular carcinoma (HCC), combined with literature analysis, terms histone variant H2A.Z. Cell phenotype assay confirmed effect H2A.Z on proliferation, metastasis, apoptosis, cell cycle HCC cells. was shown function via tumor dysregulation signaling pathway, BCL6 its...
At present, immunotherapy has become an important treatment for lung cancer. With the widespread use of immune checkpoint inhibitors (ICIs), we must be strict with emergence related adverse events (irAEs). There are also some patients who do not respond to immunotherapy. However, there was no biomarkers predict safety and efficacy The selection beneficiaries contributes improving cancer treatment.The electronic medical records 221 complete clinical data received from First Affiliated...
Rosmarinic acid (RA) is a natural polyphenolic compound that exists in many medicinal species of Boraginaceae and Lamiaceae. The previous studies have revealed RA had therapeutic effects on hepatocellular carcinoma (HCC) the H22-xenograft models by inhibiting inflammatory cytokines NF-κB p65 pathway tumor microenvironment. However, its molecular mechanisms immunoregulation pro-apoptotic effect HCC not been fully explored. In present study, at 75, 150, 300 mg/kg was given to H22 tumor-bearing...
Intratumor heterogeneity (ITH) has been associated with poor prognosis in advanced non-small cell cancer (NSCLC) patients receiving immune checkpoint blockade (ICB) therapies. However, there is currently no evidence supporting an ITH metric as a predictor of clinical benefit from ICB. The unique advantages blood make it promising material for estimation and relevant applications. This study aims to develop validate blood-based index predicting ICB response.NSCLC the OAK POPLAR trials were...
Radix Pueraria lobata has been recognized as a medicine and functional food, whose polysaccharide is its main bioactive component. In this study, we employed the response surface method to optimize extraction of from Puerariae lobatae (PLP). Based on single-factor experiment, three levels liquid–material ratio, time, temperature were selected for experiment. We established quadratic regression equation rate. The optimal combination conditions obtained through analysis ridge analysis. yield...
Abstract Background Radiotherapy is a viable treatment option for patients with unresectable hepatocellular carcinoma (HCC). However, radiation resistance an issue that needs to be addressed. In this context, cumulative evidence supports the functional roles of variety RNA or proteins in radioresistance, and suggests modulation their expression may constitute novel radiosensitization approach. Here, we investigated ability collectrin (CLTRN) enhance radiosensitivity HCC first time. Methods...
From 2009, Ministry of Health in China continues to develop and promote the construction residents' electronic health records. The corresponding standards were pronounced by Health. Under national standards, we developed a resident's records system. In order improve effective medical staff's daily management, visualization residents address is added our system composed variety chronic diseases query statistical database model. All routes among addresses are marked on map. best route visit...