A5014127513- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Biopolymer Synthesis and Applications
- Lung Cancer Treatments and Mutations
- Angiogenesis and VEGF in Cancer
- interferon and immune responses
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Advanced Breast Cancer Therapies
- Cytokine Signaling Pathways and Interactions
- 14-3-3 protein interactions
Taizhou People's Hospital
2022-2025
Nanjing Medical University
2022-2025
Nantong University
2021-2025
Affiliated Hospital of Nantong University
2021
Increased angiogenesis in the liver plays a critical role progression of hepatocellular carcinoma (HCC). However, molecular mechanism underlying increased HCC is not well understood. Current study was designed to identify potential angiogenic effect RNA-binding motif 4 (RBM4)through small-scale overexpression screening, followed by comparison expression level RBM4 cancer and adjacent tissues multiple malignancies explore relationship between CD31 protein related clinical indicators,...
Although angiogenesis is a critical event in hepatocellular carcinoma (HCC), and this process provides the tumor with sufficient oxygen nutrients, precise molecular mechanism by which it occurs not fully understood. NEDD4 binding protein 3 (N4BP3) was identified study as novel pro-angiogenic factor HCC cell lines tissues. We discovered that N4BP3 significantly expressed its level of expression positively correlated density microvessels Cell biology experiments have shown knockdown cells...
Dynein axonemal assembly factor 5 (DNAAF5) is the transcription of regulating cytoskeleton and hydrodynamic protein complex assembly, however, it was not well elucidated in malignant progression hepatocellular carcinoma (HCC).We investigated role DNAAF5 by using multiple groups clinical tissues combined with data from TCGA database. Then we overexpressed tumor tissues, which correlates poor patient survival outcomes. Furthermore, constructed stable cell lines HCC cells to confirm...
Background: NAT10 (N-acetyltransferase 10) is a newly identified novel acetyltransferase. Abnormal expression of associated with several human disorders, including cancer, autoimmune diseases, and cardiovascular disease. This study aimed to investigate the role in promoting lung cancer malignant progression through NF-κB (nuclear factor κB) signaling pathway. Methods: Cells lines BEAS-2B, NCI-H524, A549, PC-9, NCI-H23, NCI-H258 were cultured for identification. Western blotting PCR assays...
Purpose. Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and angiogenesis has been proven to be significantly involved in its progression. However, the molecular mechanism underlying HCC not well researched. In this study, RNA Binding Motif Protein 23 (RBM23) was identified as novel proangiogenic factor cell lines tissues. Materials Methods. Firstly, we analyzed correlation clinical specimens. tissues, levels RBM23 microvessel density (MVD) showed strong...
Hepatocellular carcinoma (HCC) is characterized by frequent intrahepatic and distant metastases, resulting in a poor prognosis for patients. Epithelial-mesenchymal transition (EMT) plays pivotal role this process. However, the expression of NOP2/Sun RNA methyltransferase 5 (NSUN5) HCC its mediating EMT remain poorly understood. In study, clinicopathological analyses are conducted across multiple independent cohorts induced tumor formation Nsun5-knockout mice. The findings reveal an...
Abstract Hepatocellular carcinoma (HCC), the most prevalent liver cancer, makes patients' prognosis extremely poor due to frequent intrahepatic and distant metastasis. The epithelial-mesenchymal transition (EMT) plays an important role in this process. However, content of NSUN5 hepatocellular whether is involved mediating remains unknown. In study, based on clinicopathologic analyses several independent HCC cohorts results induced tumor formation Nsun5 knockout mice, we observed that...