A5100454501- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ovarian function and disorders
- MicroRNA in disease regulation
- Lipid metabolism and disorders
- Cancer-related gene regulation
- Reproductive Biology and Fertility
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Nicotinic Acetylcholine Receptors Study
- Inflammasome and immune disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Multiple Myeloma Research and Treatments
- Neuroscience and Neuropharmacology Research
- Toxic Organic Pollutants Impact
- SARS-CoV-2 detection and testing
- Immune Response and Inflammation
- Stress Responses and Cortisol
- Assisted Reproductive Technology and Twin Pregnancy
- Acute Myeloid Leukemia Research
Jinan University
2016-2025
Southern Medical University
2012-2025
Nanfang Hospital
2023-2025
University of Minnesota
2025
Lanzhou University
2025
Lanzhou University Second Hospital
2025
Shenzhen Bay Laboratory
2025
Chengde Medical University
2024-2025
Shandong First Medical University
2022-2024
Baoding People's Hospital
2022-2024
Throughout most of the mammalian genome, genetically regulated developmental programming establishes diverse yet predictable epigenetic states across differentiated cells and tissues. At metastable epialleles (MEs), conversely, epigenotype is established stochastically in early embryo then maintained lineages, resulting dramatic systemic interindividual variation regulation. In mouse, maternal nutrition affects this process, with permanent phenotypic consequences for offspring. MEs have not...
N6-methyladenosine (m6A) is the most abundant internal modification in mammalian mRNAs. Despite its functional importance various physiological events, role of m6A chemical carcinogenesis remains largely unknown. Here we profiled dynamic mRNA during cellular transformation induced by carcinogens and identified a subset cell transformation-related, concordantly modulated sites. Notably, increased 3'-UTR oncogene CDCP1 was found malignant transformed cells. Mechanistically, methyltransferase...
GH is an important regulator of body growth and composition as well numerous other metabolic processes. In particular, liver plays a key role in the GH/IGF-I axis, because majority circulating "endocrine" IGF-I results from GH-stimulated production. To develop better understanding overall function GH, we generated strain mice with liver-specific receptor (GHR) gene knockout (LiGHRKO mice). LiGHRKO had 90% decrease levels, 300% increase significant changes IGF binding protein (IGFBP)-1,...
Non-alcoholic fatty liver disease (NAFLD) and -steatohepatitis (NASH) imply a state of excessive fat built-up in livers with/or without inflammation have led to serious medical concerns recent years. Antrodan (Ant), purified β-glucan from A. cinnamomea has been shown exhibit tremendous bioactivity, including hepatoprotective, antihyperlipidemic, antiliver cancer, anti-inflammatory effects. Considering the already well-known alleviating bioactivity for alcoholic steatohepatitis (ASH), we...
Abstract Since October 2020, novel strains of SARS-CoV-2 including B.1.1.7, have been identified to be global significance from an infection and surveillance perspective. While this strain (B.1.1.7) may play important role in increased COVID rates the UK, there are still no reported account for spike cases Los Angeles (LA) California as a whole, which currently has some highest absolute per-capita transmission country. From early days pandemic when LA only had single viral genome uploaded...
Intestinal organoid transplantation is a promising therapy for the treatment of mucosal injury. However, how transplanted organoids regulate immune microenvironment recipient mice and their role in treating intestinal ischemia-reperfusion (I/R) injury remains unclear. Here, we establish method transplanting into I/R mice. We find that improve mouse survival, promote self-renewal stem cells after I/R, depending on enhanced ability macrophages polarized to an anti-inflammatory M2 phenotype....
There are significant differences in the susceptibility of populations to intestinal ischemia/reperfusion (I/R), but underlying mechanisms remain elusive. Here, we show that mice exhibit I/R-induced enterogenic sepsis. Notably, milnacipran (MC) content enterogenic-sepsis-tolerant is significantly higher. We also reveal pre-operative fecal MC cardiopulmonary bypass patients, including those with I/R injury, associated post-operative gastrointestinal injury. attenuates mouse injury wild-type...
The Nicotiana tabacum L. plant, a medicinal resource, holds significant potential for benefiting human health, as evidenced by its use in Native American and ancient Chinese cultures. Modern medical pharmaceutical studies have investigated that the abundant distinctive function metabolites tobacco including nicotine, solanesol, cembranoid diterpenes, essential oil, seed oil other extracts, avoiding toxic components of smoke, mainly anti-oxidation, anti-lipid production, pro-lipid oxidation,...
Sex differences in secular trends of stroke incidence are rarely reported. We aimed to explore sex and mortality rural China from 1992 2012.In 1992, 14 920 residents were recruited participate the Tianjin Brain Study, a population-based study on surveillance. Stroke events all deaths annually registered.We observed 908 incident strokes (366 women) 2012. Women significantly younger than men (64±12 versus 68±11 years) 1998 (P=0.024). The first-ever per 100 000 person-years for was 166 1998,...
Although valproic acid (VPA), has been shown to induce neuronal differentiation of neural stem cells (NSCs), the underlying mechanisms remain poorly understood. Here we investigated if and how mammalian target rapamycin (mTOR) signaling is involved in VPA-induced NSCs. Our data demonstrated that mTOR activation not only promoted but also was necessary for NSCs induced by VPA. We further found inhibition blocked demethylation neuron-specific gene neurogenin 1 (Ngn1) regulatory element cells....
NOD-like receptor protein 3 (NLRP3) inflammasome was reported as expressed in schistosomiasis-induced liver fibrosis (SSLF). We used an NLRP3 inhibitor, MCC950, to investigate whether it inhibited fibrosis, and explored the preliminary molecular mechanism. BALB/c mice were infected with 15 cercariae through abdominal skin. They received intraperitoneal injections of MCC950 on day infection at 22 post-infection. examined their SSLF phenotype effect primary Kupffer cells (KCs), HSCs. Human...
Non-alcoholic fatty liver disease (NAFLD) has become a major chronic in contemporary society, affected by N6-methyladenosine (m6A) RNA methylation, one of the most common modifications. Compared with healthy control, m6A methyltransferase 3 (METTL3) and METTL14 increased, while Wilms tumor 1-associated protein (WTAP) RNA-binding motif 15 (RBM15) decreased significantly NAFLD, demethylases fat mass obesity-associated (FTO) elevated. Meanwhile, binding proteins, YT521-B homology (YTH)...
Multiple animals and in vitro studies have demonstrated that perfluoroalkyl polyfluoroalkyl substances (PFASs) exposure causes liver damage associated with fat metabolism. However, it is lack of population evidence for the correlation between PFAS nonalcoholic fatty disease (NAFLD). A cross-sectional analysis was performed 1150 participants aged over 20 from US. Liver ultrasound transient elastography to identify NAFLD multiple biomarkers were indicators hepatic steatosis fibrosis. Logistics...
Nickel (Ni) compounds are potent carcinogens and can induce malignant transformation of rodent human cells. To uncover the molecular mechanisms nickel sulfide (NiS)-induced cell transformation, we investigated epigenetic alterations in a set DNA repair genes. The silencing O(6)-methylguanine methyltransferase (MGMT) gene locus upregulation 1 (DNMT1) expression was specifically detected NiS-transformed bronchial epithelial (16HBE) In addition, noted including hypermethylation, reduced histone...
Nickel (Ni) compounds are well-recognized human carcinogens, yet the molecular mechanisms by which they cause cancer still not well understood. MicroRNAs (miRNAs), small non-coding RNAs, involved in diverse biological functions and carcinogenesis. In previous study, we identified upregulation of DNA methyltransferase 1 (DNMT1) expression nickel sulfide (NiS)-transformed bronchial epithelial (16HBE) cells. Here, investigated whether some miRNAs aberrantly expressed targets DNMT1...
Abstract Background High levels of circulating cell‐free DNA (cf ) have been reported in patients with inflammatory conditions. The aim the study was to investigate cf systemic lupus erythematosus ( SLE ). Materials and methods Comparative groups comprised 22 nonpregnant 36 pregnant women (test groups) 60 199 no history (control groups). plasma were quantitated by a fluorometric ds assay. Results Compared controls, median significantly higher (7.38 ng/mL vs 4.6 ng/mL, P = 0.033) (7.65 5.25...