A5100636036- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Myasthenia Gravis and Thymoma
- Neuroinflammation and Neurodegeneration Mechanisms
- Antifungal resistance and susceptibility
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- Pancreatitis Pathology and Treatment
- Hereditary Neurological Disorders
- Ocular Diseases and Behçet’s Syndrome
- Protein Tyrosine Phosphatases
- Retinal and Optic Conditions
- Neurotransmitter Receptor Influence on Behavior
- Anesthesia and Neurotoxicity Research
- Sepsis Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Advanced Neuroimaging Techniques and Applications
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Retinal Imaging and Analysis
- Long-Term Effects of COVID-19
- CNS Lymphoma Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
- Parkinson's Disease and Spinal Disorders
Tianjin Medical University General Hospital
2016-2025
UNSW Sydney
2025
Nanjing Medical University
2016-2025
Taizhou People's Hospital
2025
Nantong University
2025
Guangxi Medical University
2025
Zhuzhou Central Hospital
2025
Central South University
2021-2025
Women's Hospital, School of Medicine, Zhejiang University
2024
Shandong First Medical University
2024
Abstract Overweight or obese body habitus is associated with cognitive deficits, impaired brain function, gray matter atrophy, and white (WM) hyperintensities. However, few diffusion tensor imaging (DTI) studies have assessed WM integrity in relation to overweight status. This study relationships between mass index (BMI) values of DTI parameters among 51 normal weight (lean), overweight, participants who were otherwise healthy. BMI correlated negatively fractional anisotropy axial...
Timely and accurate diagnosis of RNA viruses, represented by the SARS-CoV-2, is foundation for protecting people from health threats. Currently, direct detection viral genes remains most...
Although it is inarguable that conventional MRI (cMRI) has greatly contributed to the diagnosis and assessment of multiple sclerosis (MS), cMRI does not show close correlation with clinical findings or pathologic features, unable predict prognosis stratify disease severity. To this end, diffusion tensor imaging (DTI) tractography neuroconnectivity analysis may assist in MS. We, therefore, attempted pilot study for initial early relapsing‐remitting MS (RRMS). Neuroconnectivity was used...
A subset of regulatory B cells in humans and mice has been defined functionally by their ability to produce interleukin (IL)-10. We characterized IL-10-producing (B10) myasthenia gravis (MG) patients correlated them with disease activity responsiveness rituximab therapy.Frequencies B10 from MG healthy controls were monitored fluorescence-activated cell sorting (FACS).MG had fewer than controls, which was associated more severe status. Moreover, who responded well therapy exhibited rapid...
Sex differences in secular trends of stroke incidence are rarely reported. We aimed to explore sex and mortality rural China from 1992 2012.In 1992, 14 920 residents were recruited participate the Tianjin Brain Study, a population-based study on surveillance. Stroke events all deaths annually registered.We observed 908 incident strokes (366 women) 2012. Women significantly younger than men (64±12 versus 68±11 years) 1998 (P=0.024). The first-ever per 100 000 person-years for was 166 1998,...
Background: the prevalence of dementia in China has risen dramatically recent decades, but it is not well understood status elderly population Zhejiang province, eastern China. Methods: a cross-sectional survey was conducted four communities across 12 counties province from May to November 2014. Recruitment included 2,015 subjects aged 65 or older. Trained assessors performed assessments and interviews collected information. Dementia diagnosed according NIA-AA criteria 2011. Results:...
Abstract The global coronavirus disease 2019 (COVID-19) pandemic has led to a health crisis. It remains unclear how anxiety affects blood pressure (BP) and cardiovascular risk among older patients with hypertension. In this study, we extracted longitudinal data on home BP monitored via smartphone-based application in 3724 elderly hypertension from clinical trial (60–80 years; 240 Wuhan 3484 non-Wuhan areas) examine changes morning during the COVID-19 outbreak China. Anxiety was evaluated...
Laboratory determination of autoantibodies against acetylcholine receptor (AChR), muscle-specific kinase (MuSK) and other autoantigens have been integrated into the diagnosis myasthenia gravis (MG). However, evidence supporting selection methodologies is lacking.In this prospective, multicentre cohort study, we recruited patients with suspected MG to evaluate diagnostic accuracy cell-based assay (CBA), radioimmunoprecipitation (RIPA) enzyme-linked immunosorbent (ELISA) in detecting AChR MuSK...
Because the blood circulation system of retina and brain are closely related to each other, we examined whether stroke is associated with localized retinal nerve fiber layer defects (RNFLDs). Patients acute ischemic as part a hospital-based study group were compared participants population-based Beijing Eye Study. The was imaged by spectral-domain optical coherence tomography for detection RNFLDs. included 154 patients 2890 subjects from Study whom tomographic images data on previous...
The objective of this study was to explore the effects intermittent hydrostatic pressure (IHP) on chondrogenic differentiation cartilage progenitor cells (CPCs) cultivated in alginate beads. CPCs were isolated from knee joint rabbits, and infrapatellar fat pad-derived stem (FPSCs) chondrocytes (CCs) included as control cell types. Cells embedded beads treated with IHP at 5 Mpa 0.5 Hz for 4 h/day 1, 2, or weeks. cells' migratory proliferative capacities evaluated using scratch Live/Dead...
Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease of the central nervous system that involves B-cell receptor signaling as well astrocyte–microglia interaction, which both contribute to evolution NMOSD lesions. Main body Through transcriptomic and flow cytometry analyses, we found Bruton’s tyrosine kinase (BTK), a crucial protein was upregulated in blood cerebrospinal fluid patients. Blockade BTK with zanubrutinib, highly specific...
Abstract Irisin is a glycosylated protein formed from the hydrolysis of fibronectin type III domain‐containing 5 (FNDC5). Recent studies have demonstrated that FNDC5/Irisin involved in regulation glucose and lipid metabolism, it can inhibit inflammation neuroprotective effects. However, effect mechanism on motor neuron‐like cell lines (NSC‐34) not been reported. In this study, we used lipopolysaccharide to construct cellular oxidative stress injury models investigated potential roles neurons...
This study was conducted to estimate screening performance of dementia tools including Mini-Mental State Examination (MMSE), Mini-Cog, Clock Drawing Test (CDT) and Ascertain Dementia 8 questionnaire (AD8) for older adults. 2015 participants aged 65 years or more in eastern China were enrolled. 4 tests administered scored by specifically trained psychiatrists. We used data from two-by-two tables calculate the sensitivity, specificity, positive negative predictive values (PPV/NPV). Our showed...
A pH/redox dual stimuli-responsive clustered nanoparticles are demonstrated as vehicle for simultaneously delivering ultra-small platinum (USPtNs) and gemcitabine (GEM) to treat non-small-cell lung cancer.
Background: Remimazolam besylate for injection is a novel benzodiazepine. Reasonable selection and proper application of anesthetics critical patients. This study aims to determine the 90% effective dose (ED90) remimazolam anesthesia induction in patients undergoing painless colonoscopy.
The aim of this study was to develop and internally validate an interpretable machine learning (ML) model for predicting the risk hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) infection. We retrospectively collected clinical data from HCC CHB treated at Fourth Affiliated Hospital Guangxi Medical University January 2022 December 2022, including demographics, comorbidities, laboratory parameters. datasets were randomly divided into a training set (361 cases)...
In this study, we focused on gaining an in-depth understanding the attitudes and perceptions of hepatology healthcare professionals toward screening for cryptogenic hepatic encephalopathy (CHE), with goal providing references scientific standardized implementation CHE screening. Based phenomenological research method, semi-structured interviews nine medical were conducted in March 2023 at department a tertiary hospital Taizhou city. The collected data was then integrated analyzed using...