A5023174618- Pancreatitis Pathology and Treatment
- Air Quality and Health Impacts
- Pancreatic and Hepatic Oncology Research
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Climate Change and Health Impacts
- Air Quality Monitoring and Forecasting
- SARS-CoV-2 and COVID-19 Research
- Energy and Environment Impacts
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Gallbladder and Bile Duct Disorders
- RNA modifications and cancer
- Long-Term Effects of COVID-19
- Cancer Mechanisms and Therapy
- Kawasaki Disease and Coronary Complications
- Streptococcal Infections and Treatments
- COVID-19 diagnosis using AI
- Coronary Artery Anomalies
- DNA Repair Mechanisms
- Bacterial biofilms and quorum sensing
- Ion Transport and Channel Regulation
- Carcinogens and Genotoxicity Assessment
Hunan Normal University
2018-2025
Hunan Provincial People's Hospital
2015-2025
Central South University
2014-2018
Fudan University Shanghai Cancer Center
2016
The Military General Hospital of Beijing PLA
2016
Third Xiangya Hospital
2014
University of Tasmania
2003
Abstract COVID‐19 has developed into a worldwide pandemic; early identification of severe illness is critical for controlling it and improving the prognosis patients with limited medical resources. The present study aimed to analyze characteristics identify biomarkers differential diagnosis prediction. In total, 27 consecutive 75 flu were retrospectively enrolled. Clinical parameters collected from electronic records. disease course was divided four stages: initial, progression, peak,...
To evaluate alterations of the intestinal bacteria and its associations with inflammation in acute pancreatitis (AP).A multihospital prospective clinical study was conducted, a total 108 participants were enrolled our study, including 44 severe AP (SAP), 32 mild (MAP), healthy volunteers. The structure microbiota, 10 predominant bacteria, plasma endotoxin, serum cytokines investigated by polymerase chain reaction-denaturing gradient gel electrophoresis, real-time quantitative reaction,...
Studies have shown that some cytokines in COVID-19 patients were elevated. This study aims to assess whether IL-10, IL-1β, IL-6, MCP-1, TNF-α, IP-10 and IL-4 serve as potential diagnostic biomarkers of COVID-19.The above serum non-COVID-19 detected by ELISA SARS-CoV-2 IgM IgG the chemiluminescence method. The independent-sample Mann-Whitney U test was utilised compare cytokine levels different groups courses, Levene T-test T'-test they genders Spearman correlation analyse between with ages...
Recently, some global cases of 2019 novel coronavirus (COVID-19) pneumonia have been caused by second-or third-generation transmission the viral infection, resulting in no traceable epidemiological history.Owing to complications COVID-19 pneumonia, first symptom and imaging features patients can be very atypical early diagnosis infections remains a challenge.It would aid radiologists clinicians aware disease contribute prevention infected being missed.
The critical role of microRNAs in cancer development has been extensively described. miRNAs are both specific markers and putative therapy targets. miR-155 identified to be an oncomiRNA is highly expressed several solid cancers, including glioblastoma. In this study, we found that a good potential target. Knockdown sensitizes glioma cells the chemotherapy temozolomide (TMZ) by targeting p38 isoforms mitogen-activated protein kinase 13 [MAPK13, also known as MAPKδ or stress-activated 4...
Abstract Kawasaki disease (KD) is a multi-systemic vasculitis of unknown etiology that occurs mainly in children, and the disturbance gut microbiota generally believed to cause hyperimmune reaction triggering KD. The aim study was investigate alterations fecal assess its relationship with systemic inflammation. Totally 30 KD children were enrolled followed up for 6 months, another group age- sex-matched healthy as controls. Phylotype profiles microbial communities analyzed using 16S rRNA...
Abstract NO (nitric oxide)-mediated protein S -nitrosylation has been established as one major signaling mechanism underlying cancer initiation and development, but its roles in PDAC (pancreatic ductal adenocarcinoma) pathogenesis still remain largely unexplored. In this study, we identified 585 unique S- nitrosylation sites among 434 proteins patients PANC-1 cell line by a site-specific proteomics. Larger number of nitrosylated were tissues cells than adjacent non-cancerous tissues. These...
Effective early diagnosis and timely intervention in acute pancreatitis (AP) are essential for improving patient outcomes. This study aims to evaluate the clinical utility of neutrophil CD64 index (nCD64) stratifying patients with SAP assessing mortality risk. A total 302 AP were enrolled divided into a training cohort (n = 226) validation 76). Venous blood samples collected within 24 hours admission, nCD64 was measured via flow cytometry. Other parameters, including C-reactive protein (CRP)...
Abstract Fine particulate matter (PM 2.5 ) is one of the four major causes mortality globally. The objective this study was to investigate mechanism underlying liver injury following exposure PM and involvement circRNA in its regulation. A respiratory tract model established SPF SD male rats with a dose 20 mg/kg, tissue control group -exposed groups were detected. results ICP-MS showed that Mn, Cu Ni enriched liver. HE staining significant pathological changes tissues group, transmission...
Abstract Background The purpose of our study is to analyze the microbiological and clinical characteristics carbapenem‐resistant hypervirulent Klebsiella pneumoniae (CR‐hvKP) that causes nosocomial infection. Methods We collected K . (CRKP) strains caused infection in a hospital China relevant data. characterized these for their antimicrobial virulence‐associated phenotype genotype analyzed clonal relatedness. screened compared them with non‐hypervirulent strains. Results retrospectively 62...
Severe acute pancreatitis (SAP) is a serious inflammatory disease that often associated with high mortality rate. It tends to trigger cascade of systemic inflammation causes damage multiple organs, such as the lungs and kidneys. Currently, there no effective treatment plan reverse progress SAP. The occurrence development SAP are oxidative stress (OS) ferroptosis. In this study, Ca/Fe-based nanozymes used multi-enzyme simulants, which can effectively remove reactive oxygen species regulate...
Abstract Background Protein cysteine oxidation is substantially involved in various biological and pathogenic processes, but its implications pancreatic cancer development remains poorly understood. Methods results In this study, we performed a global characterization of protein targets PDAC cells through iodoTMT-based quantitative proteomics, which identified over 4300 oxidized sites more than 2100 proteins HPDE6c7 PANC-1 cells. Among them, 1715 residues were shown to be differentially...
Our objective is to evaluate the accuracy of three algorithms in differentiating origins outflow tract ventricular arrhythmias (OTVAs). This study involved 110 consecutive patients with OTVAs for whom a standard 12-lead surface electrocardiogram (ECG) showed typical left bundle branch block morphology an inferior axis. All ECG tracings were retrospectively analyzed using following recently published algorithms: 1) transitional zone (TZ) index, 2) V2 transition ratio, and 3) R wave duration...
Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) performs essential roles in regulating cancer initiation and progression, but its implication pancreatic ductal adenocarcinoma (PDAC) requires further elucidation. In this study, asymmetric dimethylarginine (ADMA)-containing peptides PDAC cell line PANC-1 were identified label-free quantitative proteomics combined with affinity purification, using human non-cancerous epithelium HPDE6c7 as the control. total, 289...
This study aimed to evaluate the potential effect of hyperhomocysteinemia on multiple organ failure (MOF) in patients with acute pancreatitis (AP).In this cohort study, a total 1880 AP were enrolled and divided into group (study group) control based serum homocysteine (HCY) levels. Clinical data including demographics, clinical outcomes, characteristics collected for analysis. Risk factors MOF determined by univariate multivariate logistic regression analyses.The showed higher rates (31.83%...