A5070426230- Metabolomics and Mass Spectrometry Studies
- Sepsis Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Circular RNAs in diseases
- Paraquat toxicity studies and treatments
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
- Heat shock proteins research
- Immune Response and Inflammation
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Pancreatitis Pathology and Treatment
- RNA modifications and cancer
- Medicinal Plants and Bioactive Compounds
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related gene regulation
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
Hunan Normal University
2005-2025
Hunan Provincial People's Hospital
2017-2025
Hubei University
2025
West China Second University Hospital of Sichuan University
2025
Sichuan University
2024-2025
Southwest Medical University
2022-2025
Guangdong Ocean University
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2023
Hunan Institute of Microbiology
2023
Xiamen University
2017-2021
Doxorubicin (DOX) is an anthracycline drug with a wide spectrum of antineoplastic activities. However, it causes cardiac cytotoxicity, and this limits its clinical applications. MicroRNA-21 (miR-21) plays vital role in regulating cell proliferation apoptosis. While miR-21 preferentially expressed adult cardiomyocytes involved development heart disease, little known regarding biological functions responding to DOX-induced cytotoxicity. In study, the effects DOX on mouse function expression...
Alzheimer’s disease (AD) is the most common cause of dementia among senior citizen. Ganoderma lucidum triterpenoids (GLTs) have nutritional health benefits and has been shown to promote longevity, but a protective effect GLTs on AD damage not yet reported. The objective this research was elucidate phylactic model mice cells explore its underlying mechanisms. Morris water maze (MWM) test conducted detect changes in cognitive function mice. Hematoxylin-eosin (HE) staining applied observe...
This study examined metabolite profile differences between serum samples of thyroid papillary carcinoma (PTC) patients and healthy controls, aiming to identify candidate biomarkers pathogenesis pathways in this cancer type. Serum were collected from PTC ( n = 80) controls 80). Using principal component analysis (PCA), partial least squares discrimination analysis(PLS-DA), orthogonal square discriminant (OPLS-DA), t -tests, the volcano plot, a model abnormal metabolic was constructed. PCA,...
Hyperlipidemia (HLP) is one of the main factors leading to cardiovascular diseases. Quercetin (QUE) a naturally occurring polyhydroxy flavonoid compound that has wide range pharmacological effects. However, potential mechanism for treating HLP remains unclear. Thus, study aimed investigate role QUE in development and its underlying mechanisms rats based on analysis gut microbiota plasma metabolomics. Following establishment an model rats, was orally administered. Plasma samples fecal were...
Abstract The Hedyotis diffusa – Scutellaria officinalis pair (HD–SB) has therapeutic effects on a variety of cancers. Our study was to explore the mechanism HD–SB in treatment hepatocellular carcinoma (HCC). A total 217 active ingredients and 1196 HCC-related targets were reserved from TCMSP SwissTarget Prediction database, we got 63 intersection GeneCards. We used Venn diagram, Cytoscape found that three core quercetin, luteolin, baicalein. PPI analysis showed TP53, CDK2, XPO1, APP....
Severe acute pancreatitis associated with lung injury (SAP-ALI) is a critical condition high mortality rate. Investigating the pathogenesis of SAP-ALI and developing effective treatments are urgently needed. Chaihuang Qingfu Pills (CHQF), traditional Chinese medicine modified from Qingyi Decoction, has been approved for treating (AP). However, its role in underlying mechanisms remain unclear. 92 AP patients were enrolled to observe protective effect CHQF on AP-ALI. L-arginine was used...
Melanoma is the most aggressive and treatment-resistant form of skin cancer. Curcumol a Chinese medicinal herb traditionally used as cancer remedy. However, molecular mechanisms underlying anticancer activity curcumol in melanoma remains largely unknown. In present study, we observed that decreased mouse B16 cell proliferation migration. The xenograft tumor assay showed reduced volume lung metastasis. upregulated expression E-cadherin downregulated N-cadherin, MMP2 MMP9 cell. Western blot...
ObjectiveSepsis is the leading course of morbidity and mortality in critically ill patients. This study aimed to evaluate predictive value platelet aggregation for patients with sepsis. In addition, relationship between impaired mitochondria was explored.MethodThis a prospective, observational cohort study. The rate response adenosine diphosphate (ADP) assessed. primary outcome 28-day mortality. Platelet mitochondrial parameters, including triphosphate(ATP), membrane potential (MMP)...
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths among cancer patients. Vascular endothelial growth factor A (VEGFA) involved in regulating biological processes, such as angiogenesis and vascular permeability, very closely related to pathogenesis various tumours, especially vascular-rich, solid tumours. Clinical data patients with HCC other tumours were analysed through public databases, TCGA database, Gene Expression Omnibus Human Protein Atlas STRING,...
Abstract Background Matrix mineralization is a key stage in bone formation involving many bone-specific genes and signaling pathways. Emerging evidence indicate that long non-coding RNA (lncRNA) microRNAs (miRNAs) play crucial roles regulating the process of osteoblasts. This study aims to characterize function mechanism lncRNA H19/miR-185-5p/IGF1 axis modulating matrix Results H19 IGF1 were highly expressed while miR-185-5p was lowly mineralized cells. Knocking down inhibited osteoblasts,...
Idiopathic inflammatory myopathies (IIM) are a class of autoimmune diseases with high heterogeneity that can be divided into different subtypes based on clinical manifestations and myositis-specific autoantibodies (MSAs). However, even in each IIM subtype, the symptoms prognoses patients very different. Thus, identification more potential biomarkers associated classification, symptoms, prognosis is urgently needed.
In our previous study, two peptides with favorable anti-inflammatory effects, Asp-Gln-Thr-Phe (DQTF) and Gly-Tyr-Thr-Arg (GYTR), were screened from Ruditapes philippinarum using an in vitro–in silico strategy. The present study aims to investigate the ameliorative effect of (RPPs) on acute inflammation clarify potential mechanism through vitro vivo experiments. effects DQTF GYTR verified a lipopolysaccharide (LPS)-induced RAW264.7 cell model enzymatic hydrolysates was explored LPS-induced...
The formation of a heptameric apoptosome is crucial event in the intrinsic cell death pathway. Considerable progress has been made towards unraveling constituents and structure as well mechanism apoptosome-mediated caspase-9 activation. However, significant gap remains understanding this process, i.e., how seven Apaf-1·cytochrome c complexes stepwisely assemble into an apoptosome. Here, we construct biophysical model that incorporates current biochemical knowledge about We propose 11...
Oxidative stress is the main cause of acute myocardial infarction (AMI), which related to disorder regulation Bmal1 on redox state. HSPB1 form homologous‐oxidized (homooxidized HSPB1) resist oxidative damage via S‐thiolated modification. However, it still unclarified whether there an interaction between circadian clock and in injury. A total 118 AMI patients admitted treated our hospital from Sep. 2019 2020 were selected detect plasma expression We divided into three subgroups: morning‐onset...
The importance of sepsis-induced immunosuppression and its contribution to mortality has recently emerged. In this study we examined the effects Tanshinone II-A (TSN), a widely used traditional Chinese medicine, on in experimental peritonitis induced septic mice. Sepsis was achieved by means cecal ligation puncture (CLP). TSN at different doses (5, 15 45 mg/kg, i.p.) were time-points (0, 3, 6 12 h) after CLP evaluate effect survival parallel experiments, mice given optimal dose time-point...
Xuebijing (XBJ) injection, a Chinese traditional medicine is widely used in the treatment of sepsis China, and shows promising clinical therapeutic effect. However, its impacts on metabolic changes have not yet been reported. We established septic rat model using cecal ligation puncture (CLP) treated with XBJ or placebo (saline). The survival rates were monitored for 7d, effects liver kidney tissue morphology, serum biochemistry [alanine aminotransferase (ALT), aspartate (AST), blood urea...
The clinical use of doxorubicin (DOX) is limited by its cardiotoxicity, which closely associated with oxidative stress. Xinmailong (XML) a bioactive peptide extracted from American cockroaches, has been mainly applied to treat chronic heart failure in China. Our previous study showed that XML attenuates DOX‐induced However, the mechanism cardiotoxicity remains unclear. Heme oxygenase‐1 (HO‐1), an enzyme ubiquitously expressed all cell types, found take antioxidant effects many cardiovascular...
Paraquat (PQ) is a widely used herbicide that severely toxic to humans and animals. Pulmonary fibrosis disorder can result from PQ poisoning. Fluorofenidone (AKF‑PD) novel small molecule pyridone drug with widespread clear anti‑organ effect; however, its mechanism of action on poisoning‑induced pulmonary not clear. The purpose the present study was investigate protective effect underlying AKF‑PD fibrosis. Human alveolar epithelial cells (HPAEpiC) Sprague‑Dawley rats were treated in presence...