A5100770623- Paraquat toxicity studies and treatments
- Soil Moisture and Remote Sensing
- Traditional Chinese Medicine Analysis
- Soil and Unsaturated Flow
- Thyroid Cancer Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Tuberculosis Research and Epidemiology
- Plant-based Medicinal Research
- Antimicrobial Resistance in Staphylococcus
- Microbial Natural Products and Biosynthesis
- Landslides and related hazards
- Bacterial biofilms and quorum sensing
- Cancer, Lipids, and Metabolism
- Hydrology and Watershed Management Studies
- Cervical Cancer and HPV Research
- Hepatitis C virus research
- Biochemical and Structural Characterization
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Climate variability and models
- Liver Disease Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Galectins and Cancer Biology
- Hepatitis B Virus Studies
- Water Resources and Sustainability
Shihezi University
2025
First Affiliated Hospital of Kunming Medical University
2025
Kunming Medical University
2025
Hunan Normal University
2013-2024
Hunan Provincial People's Hospital
2010-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Shanghai Jiao Tong University
2021
Tongren Hospital
2021
Peking University
2018
Peking University Cancer Hospital
2018
Community acquired (CA) methicillin-resistant Staphylococcus aureus (MRSA) increasingly causes disease worldwide. USA300 has emerged as the predominant clone causing superficial and invasive infections in children adults USA. Epidemiological studies suggest that is more virulent than other CA-MRSA. The genetic determinants render virulence dominance to remain unclear.We sequenced genomes of two pediatric isolates: one CA-MRSA CA-methicillin susceptible (MSSA), isolated at Texas Children's...
Climate extremes have and will continue to cause severe damages buildings natural environments around the world. A full knowledge of probability climate is important for management mitigation hazards. Based on Mann–Kendall trend test copulas, this study investigated characteristics precipitation as well their implications in southwestern China (Yunnan, Guangxi Guizhou Province), through analyzing changing trends probabilistic six indices, including consecutive dry days, wet annual total day...
Hyperlipidemia (HLP) is one of the main factors leading to cardiovascular diseases. Quercetin (QUE) a naturally occurring polyhydroxy flavonoid compound that has wide range pharmacological effects. However, potential mechanism for treating HLP remains unclear. Thus, study aimed investigate role QUE in development and its underlying mechanisms rats based on analysis gut microbiota plasma metabolomics. Following establishment an model rats, was orally administered. Plasma samples fecal were...
Background Gastric cancer (GC) is a highly heterogeneous tumor with different responses to immunotherapy. Identifying immune subtypes and landscape of GC could improve immunotherapeutic strategies. Methods Based on the abundance tumor-infiltrating cells in patients from The Cancer Genome Atlas, we used unsupervised consensus clustering algorithm identify robust clusters patients, assessed their reproducibility an independent cohort Gene Expression Omnibus. We further confirmed feasibility...
Abstract The near‐surface layer of Earth which provides essential elements for supporting life is now recognized as the critical zone (CZ). This study first global assessment CZ thickness (CZT) and its controlling factors by combining data sets climate, vegetation height (VH), water table depth (WTD), groundwater (GWT), topography, lithologic data. analysis shows that CZT ranges from 0.7 to 223.5 m with an average value 36.8 across continental areas; thickest in midlatitudes (subtropical...
Elevated serum YKL-40 levels have been observed in various cancers. We evaluated the diagnostic performance of alone or combination with CEA, CYFRA21-1 and SCCA tumor markers for patients esophageal squamous cell carcinoma (ESCC). was detected ESCC lines tissues by real-time RT-PCR, Western blotting ELISA. protein expression determined 20 using immunohistochemistry. Serum measured ELISA 126 healthy donors, 59 benign diseases 150 ESCC. were electrochemiluminescence. mRNA cancer lines, culture...
To investigate the value of multiparameter joint analysis in early diagnosis gastric cancer (GC) clinical practice.Concentrations CEA, CA724 and three kinds cytokines (TNF-α, IL-6 IL-8) 176 GC patients, 117 atypical hyperplasia 204 healthy control individuals were used for building diagnostic model, then 58 41 66 enrolled independently. The joints indicators analyzed by binary logistic regression method.For discriminating group group, had best value, area under curve (AUC) was 0.95...
Background: Papillary thyroid carcinoma (PTC) frequently metastasizes to cervical lymph nodes (LNs), with metastasis rates of 20–90%, significantly impacting patient prognosis. Although ultrasound (US) is the primary preoperative assessment tool, its accuracy (Acc) in detecting LN (LNM) remains insufficient, conventional US only 50% confirmed cases. This study aimed improve prediction LNM PTC by combining quantitative nodule orientation parameters multi-modal techniques. Methods: Data were...
Purpose While the prognosis for differentiated thyroid cancer (DTC) is favorable, health-related quality of life (QOL) survivors not well understood. This study aims to investigate factors influencing QOL DTC survivors. Methods A total 860 who underwent thyroidectomy were surveyed. Participants completed Chinese version Thyroid Cancer-Specific Quality Life (THYCA-QOL) questionnaire, European Organization Research and Treatment Cancer Core Questionnaire-C30 (EORTC QLQ-C30), additional related...
Paraquat (PQ) is a widely used herbicide that severely toxic to humans and animals. Pulmonary fibrosis disorder can result from PQ poisoning. Fluorofenidone (AKF‑PD) novel small molecule pyridone drug with widespread clear anti‑organ effect; however, its mechanism of action on poisoning‑induced pulmonary not clear. The purpose the present study was investigate protective effect underlying AKF‑PD fibrosis. Human alveolar epithelial cells (HPAEpiC) Sprague‑Dawley rats were treated in presence...
After paraquat (PQ) poisoning, it is difficult to accurately diagnose patients' condition by only measuring their blood PQ concentration. Therefore, important establish an accurate method assist in the diagnosis of especially early stages. In this study, a gas chromatography-mass spectrometry (GC-MS) metabonomics strategy was established obtain metabolite information. A random forest algorithm used search for potential biomarkers and data mining network pharmacological analysis were evaluate...
BACKGROUND:Fluorofenidone (AKF-PD) is an anti-fibrotic small-molecule compound. Its mechanism of action on paraquat (PQ)-induced pulmonary fibrosis still unclear. MATERIAL AND METHODS:Forty-eight SD rats were divided into 4 groups: control group, PQ PQ+AKF-PD and AKF-PD group. The pathological changes lung tissues observed by Masson HE staining. UPLC-QTOF-MS analysis was performed to detect the differences in metabolites among groups, then possible mechanisms anti-pulmonary effects...
An HPLC-MS/MS method has been developed and validated for the determination of venlafaxine enantiomers in human plasma applied to a pharmacokinetic study healthy Chinese volunteers. The was carried out on vancomycin chiral column (5 µm, 250 × 4.6 mm) maintained at 25°C. mobile phase methanol-water containing 30 mmol/L ammonium acetate, pH 3.3 adjusted with aqueous ammonia (8:92, v/v) flow rate 1.0 mL/min. A tandem mass spectrometer an electrospray interface operated multiple reaction...