A5101647831- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Metabolomics and Mass Spectrometry Studies
- Curcumin's Biomedical Applications
- RNA modifications and cancer
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Computational Drug Discovery Methods
- Coffee research and impacts
- Genomics, phytochemicals, and oxidative stress
- Brain Metastases and Treatment
Hunan Normal University
2024
Hunan Provincial People's Hospital
2024
Zhejiang University
2019-2023
Radiotherapy produces excessive reactive oxygen species (ROS), which can lead to DNA damage and apoptosis in tumor cells, thereby killing malignant cells. Chlorogenic acid (CGA) is a well-known antioxidant coffee due its strong ability remove ROS. However, the effect of CGA on radiotherapeutic efficacy remains unclear. In this study, we showed that could hinder therapeutic radiotherapy by inhibiting radiation-induced via scavenging ROS activating NF-E2-related factor 2 (Nrf2) system...
Ribonucleotide reductase (RR) consists of two subunits, the large subunit RRM1 and small (RRM2 or RRM2B), which is essential for DNA replication. Dysregulations RR were implicated in multiple types cancer. However, abnormal expressions biologic functions subunits liver cancer remain to be elucidated. TCGA, HCCDB, CCLE, HPA, cBioPortal, GeneMANIA utilized perform bioinformatics analysis GO, KEGG, GSEA used enrichment analysis. The RRM1, RRM2, RRM2B remarkably upregulated among tissue both...