A5100362024- Antibiotics Pharmacokinetics and Efficacy
- Statistical Methods in Clinical Trials
- Thyroid Cancer Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Diabetes Management and Research
- Analytical Chemistry and Chromatography
- Medication Adherence and Compliance
- Pharmaceutical studies and practices
- Pharmacogenetics and Drug Metabolism
- Diabetes Treatment and Management
- Estrogen and related hormone effects
- Neutropenia and Cancer Infections
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- Cervical Cancer and HPV Research
- Growth Hormone and Insulin-like Growth Factors
- Microbial infections and disease research
- Diabetic Foot Ulcer Assessment and Management
- Drug Transport and Resistance Mechanisms
- Blood disorders and treatments
- Natural Antidiabetic Agents Studies
- Thyroid and Parathyroid Surgery
- Fractional Differential Equations Solutions
- Bipolar Disorder and Treatment
Shihezi University
2022-2025
First Affiliated Hospital of Shihezi University Medical College
2021-2025
Huazhong University of Science and Technology
2010-2024
Tongji Hospital
2010-2024
Université de Montréal
2015-2024
Heidelberg University
2023
Central Institute of Mental Health
2023
Xiamen University
2023
Fujian Medical University
2022-2023
Peking University
2023
Abstract Background Type 1 diabetes mellitus (T1DM) is associated with an increased risk for cardiovascular disease (CVD) related morbidity and premature mortality. Regular physical activity plays important role in the primary secondary prevention of CVD, improving overall health wellbeing. Previous observational studies have examined associations between self-reported CVD factors largely adult Caucasian populations. However, limited work has evaluated relationship objectively measured other...
The aim of this study was to establish antimicrobial susceptibility breakpoints for tilmicosin against Haemophilus parasuis, which is an important pathogen respiratory tract infections. minimum inhibitory concentrations (MICs) 103 H. parasuis isolates were determined by the agar dilution method. wild type (WT) distribution and epidemiologic cutoff value (ECV) evaluated statistical analysis. new bronchoaveolar lavage used intrapulmonary pharmacokinetic (PK) model in swine. parameters...
Ectopic TSH-secreting pituitary adenoma (TSH-oma) is a very unusual disorder. To date, there are only four cases reported. It difficult to distinguish ectopic from both regular TSH-omas and resistance thyroid hormone (RTH). A newly identified case of TSH-oma arising the nasal pharynx was described, reports prior were reviewed. The patient 41-year-old male who developed what appeared be typical hyperthyroidism atrial fibrillation in 2009. Thyroid function tests showed elevated basal levels...
Flos sophorae immaturus (FSI) is considered to be a natural hypoglycemic product with the potential for a-glucosidase inhibitory activity. In this work, polyphenols α-glucosidase inhibition in FSI were identified, and then their mechanisms investigated by omission assay, interaction, type of inhibition, fluorescence spectroscopy, circular dichroism, isothermal titration calorimetry molecular docking analysis. The results showed that five polyphenols, namely rutin, quercetin, hyperoside,...
Background: Papillary thyroid carcinoma (PTC) frequently metastasizes to cervical lymph nodes (LNs), with metastasis rates of 20–90%, significantly impacting patient prognosis. Although ultrasound (US) is the primary preoperative assessment tool, its accuracy (Acc) in detecting LN (LNM) remains insufficient, conventional US only 50% confirmed cases. This study aimed improve prediction LNM PTC by combining quantitative nodule orientation parameters multi-modal techniques. Methods: Data were...
To investigate the optimal dosage which can improve clinical efficacy and minimize resistance, pharmacokinetics/pharmacodynamics model of enrofloxacin was established. Effect treatments on clearance Salmonella in experimentally infected chickens simultaneously resistance selection coliforms were evaluated three treatment groups (100, PK/PD designed 4, 0.1 mg/kg b.w.) a control group. Treatment duration rounds 7-day alternated with withdrawal. Results showed that 100 b.w. completely...
Maraviroc (MVC), a specific antagonist of CCR5 expressed on macrophages and activated T cells, may modulate inflammation be useful in patients with HIV infection. In this study we used nonhuman primates to examine the effect mechanism MVC alone or combination cyclosporine (CsA) prolong cardiac allograft survivals. an established rhesus monkey model, recipients treated plus CsA showed significantly prolonged survival heart allografts (>240 d, p < 0.001). These vivo results MVC/CsA group...
Heart failure (HF) causes pathological changes in multiple organs, thus affecting the pharmacokinetics (PK) of drugs. The aim this study was to investigate PK candesartan patients with HF while examining significant covariates and their related impact on estimated clearance using a population (Pop-PK) modeling approach. Data from prospective, multicenter were used. Modeling simulations conducted Nonlinear Mixed-Effects (NONMEM) R software. A total 281 white included develop Pop-PK model....
Aldosterone plays an important role in the pathogenesis of non-familial atrial fibrillation (AF). We tested hypothesis that -344T/C polymorphism aldosterone synthase gene may be associated with AF Chinese patients hypertension.We performed a 1:1 paired case-control study 310 cases hypertension and same number matched controls. The was determined polymerase chain reaction-restriction fragment length polymorphism.The distribution CYP11B2 genotypes (TT, TC CC) 41.9%, 50.6%, 7.4% patients, which...
ChatGPT (Chat Generative Pre-trained Transformer) is a chat robot program developed by OpenAI (OpenAI Incorporated, Mission District, San Francisco, USA). It natural-language processing tool driven artificial intelligence technology. can complete tasks such as writing emails, video scripts, copywriting, translation, coding, and papers. At present, several studies have been conducted on the use of this for academic writing, so we report rare case suprasellar ectopic pituitary neuroendocrine...