A5006600746- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Ginseng Biological Effects and Applications
- Protein Tyrosine Phosphatases
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Galectins and Cancer Biology
- Toxin Mechanisms and Immunotoxins
- Biomarkers in Disease Mechanisms
- Pancreatitis Pathology and Treatment
- Psoriasis: Treatment and Pathogenesis
- Biochemical and Molecular Research
- Amino Acid Enzymes and Metabolism
- Plant biochemistry and biosynthesis
- Inflammation biomarkers and pathways
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
- Cancer therapeutics and mechanisms
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
Hunan Normal University
2025
Hunan Provincial People's Hospital
2025
Central South University
2020-2024
Severe acute pancreatitis associated with lung injury (SAP-ALI) is a critical condition high mortality rate. Investigating the pathogenesis of SAP-ALI and developing effective treatments are urgently needed. Chaihuang Qingfu Pills (CHQF), traditional Chinese medicine modified from Qingyi Decoction, has been approved for treating (AP). However, its role in underlying mechanisms remain unclear. 92 AP patients were enrolled to observe protective effect CHQF on AP-ALI. L-arginine was used...
Abstract Argininosuccinate synthase (ASS1) is a ubiquitous enzyme in mammals that catalyzes the formation of argininosuccinate from citrulline and aspartate. ASS1 genetic deficiency patients leads to an autosomal recessive urea cycle disorder citrullinemia, while its somatic silence or down-regulation very common various human cancers. Here, we show functions as tumor suppressor breast cancer, pesticide spinosyn A (SPA) derivative LM-2I suppress cell proliferation growth by binding...
Abstract Argininosuccinate synthase (ASS1), a critical enzyme in the urea cycle, acts as tumor suppressor many cancers. To date, anticancer mechanism of ASS1 has not been fully elucidated. Here, we found that phosphoglycerate dehydrogenase (PHGDH), key rate-limiting serine synthesis, is pivotal protein interacts with ASS1. Our results showed directly binds to PHGDH and promotes its ubiquitination-mediated degradation inhibit consequently suppressing tumorigenesis. Importantly, suppressive...
Breast cancer (BC) is a common malignant tumor with poor prognosis. Angiogenesis related to the growth and progression of solid tumors associated ZLM-7, SP1, VEGFA miR-212-3p were BC angiogenesis proliferation, however detailed mechanism was not clear. This study aimed reveal regulatory BC.BC cell lines treated 10 nM ZLM-7 for 8 h. We detected protein expression level by western blot RNA qRT-PCR. Overexpression or inhibition performed using mimics inhibitor, Sp1 overexpression pcDNA3.1...
Triple-negative breast cancer (TNBC) is the most aggressive subtype, with shorter five-year survival than other subtypes, and lacks targeted hormonal treatment strategies. The signal transducer activator of transcription 3 (STAT3) signaling up-regulated in various tumors, including TNBC, plays a vital role regulating expression multiple proliferation- apoptosis-related genes.By combining unique structures natural compounds STA-21 Aulosirazole antitumor activities, we synthesized class novel...
Psoriasis, which severely affects the sufferer's life quality, is a chronic skin disease still lacking satisfactory medication. Recently, signal transducer and activator of transcription 3 (STAT3) was revealed playing an important role in progression psoriasis. In this paper, total 59 quinone derivatives with various scaffolds were designed, synthesized, evaluated for antipsoriatic potential as STAT3 inhibitors. Among them,
Spinosyn A (SPA), derived from a soil microorganism, Saccharopolyspora spinosa, and its derivative, LM2I, has potential inhibitory effects on variety of cancer cells. However, the SPA LM2I in inhibiting growth human colorectal cells molecular mechanisms underlying these are not fully understood. Cell viability was tested by using 3-(4,5-dimethylthiazol-2-yl-)-2,5-diphenyltetrazolium bromide (MTT) assay colony formation assay. On basis IC50 values seven (CRC) cell lines, sensitive (HT29...
Ginseng (Panax ginseng C.A. Mey.) is a precious Chinese traditional medicine, for which ginsenosides are the most important medicinal ingredients. Cytochrome P450 enzymes (CYP450) and their primary redox molecular companion NADPH cytochrome reductase (CPR) play key role in ginsenoside biosynthesis pathway. However, systematic studies of CPR genes have not been reported. Numerous on synthesis biology still use Arabidopsis (AtCPR1) as reductase. In this study, we isolated two (PgCPR1, PgCPR2)...
<title>Abstract</title> Triple-negative breast cancer (TNBC) is the most malignant molecular subtype of characterized by its strong aggressiveness, high mortality, significant heterogeneity, and poor prognosis. AMPK plays a critical role in maintain cellular energy balance, inactivation associated with malignancy cancer. Here, we identified pharmacological mechanism 1, 4-naphthoquinone derivative ZSW-4B. The MTT assay, colony formation as-say, nude mouse xenograft tumor model demonstrated...
Triple-negative breast cancer (TNBC) is the most malignant molecular subtype of and characterized by aggressiveness, high mortality, significant heterogeneity, poor prognosis. AMPK plays a critical role in maintaining cellular energy balance, its inactivation associated with cancer. Here, we identified pharmacological mechanism 1,4-naphthoquinone derivative ZSW-4B. MTT, colony formation, nude mouse xenograft tumour models demonstrated that ZSW-4B selectively inhibits proliferation TNBC cells...