A5101525846- CAR-T cell therapy research
- Galectins and Cancer Biology
- Helicobacter pylori-related gastroenterology studies
- Virus-based gene therapy research
- Biomedical Ethics and Regulation
- RNA modifications and cancer
- Biomedical and Engineering Education
- Risk and Safety Analysis
- Occupational Health and Safety Research
- Human-Automation Interaction and Safety
- Gastric Cancer Management and Outcomes
- Anorectal Disease Treatments and Outcomes
- Blood Pressure and Hypertension Studies
- Neurofibromatosis and Schwannoma Cases
- Biosimilars and Bioanalytical Methods
- Lymphatic System and Diseases
- Diagnosis and Treatment of Venous Diseases
- Musculoskeletal pain and rehabilitation
- Immune Cell Function and Interaction
- Cardiovascular Health and Disease Prevention
- Cardiovascular Issues in Pregnancy
- Lung Cancer Treatments and Mutations
- Pediatric health and respiratory diseases
- Diabetic Foot Ulcer Assessment and Management
- Spine and Intervertebral Disc Pathology
Xi'an University of Architecture and Technology
2020-2021
Pudong Medical Center
2020
Second People’s Hospital of Huai’an
2020
Hunan Normal University
2020
Hunan Provincial People's Hospital
2015-2020
Xuzhou Medical College
2020
Nanchang University
2016-2018
United States Food and Drug Administration
2013-2018
First Affiliated Hospital of Nanchang University
2016-2018
Center for Biologics Evaluation and Research
2008-2018
Abstract Tisagenlecleucel (Kymriah; Novartis Pharmaceuticals) is a CD19-directed genetically modified autologous T-cell immunotherapy. On August 30, 2017, the FDA approved tisagenlecleucel for treatment of patients up to 25 years age with B-cell precursor acute lymphoblastic leukemia (ALL) that refractory in second or later relapse. Approval was based on complete remission (CR) rate, durability CR, and minimal residual disease (MRD) <0.01% cohort 63 children young adults relapsed ALL...
To evaluate alterations of the intestinal bacteria and its associations with inflammation in acute pancreatitis (AP).A multihospital prospective clinical study was conducted, a total 108 participants were enrolled our study, including 44 severe AP (SAP), 32 mild (MAP), healthy volunteers. The structure microbiota, 10 predominant bacteria, plasma endotoxin, serum cytokines investigated by polymerase chain reaction-denaturing gradient gel electrophoresis, real-time quantitative reaction,...
Helicobacter pylori (H. pylori) infection plays a critical role in the process of gastric carcinogenesis. However, complicated pathogenic mechanism is still unclear. Polo-like kinase 1 (PLK1) involved development multiple human malignancies, including cancer. Therefore, this study aimed to elucidate PLK1 H. pylori-induced carcinogenesis and underlying signaling mechanism.We detected expression 166 patients different stages as well established Mongolian gerbil model with by...
Autophagy acts as a double-edged sword in cancer. Over the years, there has been growing evidence of involvement autophagy-related genes (ATGs) etiology and progression Importantly, lung cancer is one most common cancers represents leading cause cancer-related mortality developing countries. The genomic variant emerged an important factor risk Here, we hypothesize that intron single-nucleotide polymorphism (SNP) rs807185 ATG4A associated with In this case-control study, genotyped SNP...
On 15 May 2015 during the 18th Annual American Society of Gene and Cell Therapy (ASGCT) Meeting1Weblink to ASGT annual meeting schedule.http://asgct.execinc.com/edibo/AM15FullSchedule#backtotopGoogle Scholar regulators from International Pharmaceutical Regulators Forum Working Group presented current expectations various international regulatory authorities for preclinical/nonclinical biodistribution (BD) studies. This session began with a presentation by an industry representative that...
Hypertension (HTN) is a major cause of death in Chinese farmers. Remoteness from population centers may independently affect HTN prevalence and severity. We used random cluster sampling to select 27 villages Yunnan province, China. Within each village, we randomly selected 50–80 men women between the ages 50 70 years. A total 1,177 participants underwent interviews blood pressure (BP) measurement. evaluated relationship BP distance participants' village town county with without adjustment...
To investigate the relationship between therapeutic efficacy in children with asthma and interleukin-13 (IL-13) rs20541 polymorphisms.Fifty moderate-to-severe were assigned to GG, GA, AA groups according IL-13 gene locus polymorphism. The patients received budesonide inhalation suspension 1 mg twice daily combined fluticasone propionate 80 µg/inhalation. improvement of clinical symptoms (gasping, coughing, wheezing), lung function, adverse reactions observed.Lung function did not...
To investigate the effect of intraoperative glucose fluctuation and postoperative interlukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) levels on short-term prognosis patients with intracranial supratentorial neoplasms.Eighty-six undergoing excision were selected in The Second Hospital Jilin University. According to condition fluctuation, divided into group A (glucose <2.2 mmol/L, n=57) B ≥2.2 n=29). Glucose was assessed by drawing 2 mL blood from internal jugular...
Aim To assess the relationship between clinical parameters and medium term recovery time of coronary artery lesions (CALs). Methods In total, 344 Kawasaki disease patients were screened 311 included followed‐up for next 2 years. Clinical records, inflammatory biomarkers collected all subjects. Results Tumour necrosis factor (TNF)‐α myoglobin (MYO) levels in without from CALs significantly higher than those with CALs. Kaplan–Meier survival analysis showed that high‐TNF‐α group, estimated...
Abstract The construction site is one of the most dangerous workplaces among all industries, workers are exposed to various hazards sources. Ubiquitous accidents occur even with detailed regulations and laws. Situation awareness theory revealed that there three processes when people dealing changing environment: perception environmental situation, comprehension what decision-making. likelihood risky behaviours increases a lot any these go wrong. In this paper, author proposed an alarm system...
Researchers have proposed several forms of beacon sensor-based hazard alarm systems for increasing construction workers’ awareness site hazards, but research on how to deploy sensors so that the system is adequate achieving timely individualized alarms scarce. Against this background, investigates impact different sensor locations in a quickly worker can receive alarms. This took an experimental study approach address objective. After prototype beacon-based was developed, tested concrete...
In a session held on May 15, 2015 during the 18th Annual American Society of Gene and Cell Therapy (ASGCT) Meeting, members International Pharmaceutical Regulators Forum Working Group (IPRF GTWG) presented current expectations various international regulatory authorities for preclinical-nonclinical biodistribution (BD) studies gene therapy products (excluding genetically modified cells) (http://www.iprp.global/working-group/gene-therapy). This was significant accomplishment because it...
Objective To evaluate the effects of Dermlin and Mepilex Border combined with oxygen therapy on bedsore. Methods 60 neoplastic hematologic disorder patients suffering from bedsores arising various causes were randomly divided into observational group (n =30) control =30). The former was treated by therapy, latter one timing irradiation infrared lamp routine surgical methods. recovery conditions observed. Results effective rate significantly higher than those [( 100％ vs 60％ ) ;x2 =17.78 ,P...
Objective To investigate the fusion sequence complexity of EML4-ALK in non-small cell lung cancer (NSCLC) patients, and potential mutation tyrosine kinase (TK) domain ALK gene. Methods In routine practice，a novel echinoderm microtubule-associated protein-like4 anaplastic lymphoma (EML4-ALK) V3c variant was detected by rapid amplification cDNA ends-polymerase chain reaction (RACE-PCR)-sequencing technology a patient with NSCLC.The further consecutive 39 cases（total 40 cases）were...
Objective To study the effect of urgotul on postoperative perianal abscess. Methods A total seventy two patients with abscess enrolled in hospital from June 2014 to 2015 were randomized double-blind manner trial group (36 cases) and control cases). The given drain exudates after operation, while treated traditional disinfection. pus groups bacterially cultured. Post-operative pain days wound healing also compared. Results Bacterial culture was positive 64 cases, a detection rate...