A5010067937- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Nail Diseases and Treatments
- Immune Cell Function and Interaction
- Clostridium difficile and Clostridium perfringens research
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Plant Pathogens and Fungal Diseases
- T-cell and B-cell Immunology
- Probiotics and Fermented Foods
- Carbon Dioxide Capture Technologies
- Cancer Immunotherapy and Biomarkers
- Cancer therapeutics and mechanisms
- Protein Degradation and Inhibitors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phase Equilibria and Thermodynamics
- Thermodynamic properties of mixtures
- vaccines and immunoinformatics approaches
- Oral health in cancer treatment
- Genomic variations and chromosomal abnormalities
- Neutropenia and Cancer Infections
- Ubiquitin and proteasome pathways
Zhengzhou University
2012-2025
Chinese PLA General Hospital
2016-2025
Memorial Sloan Kettering Cancer Center
2015-2024
Hebei University of Technology
2024
Shenzhen Institutes of Advanced Technology
2021-2024
Chinese Academy of Sciences
2021-2024
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2017-2023
Beijing Institute of Education
2023
Renji Hospital
2023
Capital Medical University
2020-2021
Candida is the most common human fungal pathogen and causes systemic infections that require neutrophils for effective host defense. Humans deficient in C-type lectin pathway adaptor protein CARD9 develop spontaneous disease targets central nervous system (CNS). However, how promotes protective antifungal immunity CNS remains unclear. Here, we show a patient with deficiency had impaired neutrophil accumulation induction of neutrophil-recruiting CXC chemokines cerebrospinal fluid despite...
Therapeutic treatment for systemic mycoses is severely hampered by the extremely limited number of antifungals. The difficulty fungal infections in central nervous system further compounded poor (CNS) penetration most antifungals due to blood-brain barrier. Only a few fungistatic azole drugs, such as fluconazole, show reasonable CNS penetration. Here we demonstrate that sertraline (Zoloft), frequently prescribed antidepressant, displays potent antifungal activity against Cryptococcus...
Cryptococcus neoformans is a ubiquitous human fungal pathogen. This pathogen can undergo morphotype transition between the yeast and filamentous form such morphological has been implicated in virulence for decades. Morphotype typically observed during mating, which governed by pheromone signaling. Paradoxically, components specific to signaling pathways play no or minimal direct roles virulence. Thus, link underlying molecular mechanism remain elusive. Here, we demonstrate that filamentation...
The objective of this study was to identify existing clinical compounds that either possess a fungicidal activity alone or can act synergistically with fungistatic antifungals. We screened compound library for drugs exhibited anti-Aspergillus activity. Among selected compounds, the cationic peptide antibiotic polymyxin B chosen further characterization because it be used parenterally and topically. effect its synergistic interactions azole antifungals were tested against variety fungal...
ABSTRACT Cryptococcus neoformans is an unconventional dimorphic fungus that can grow either as a yeast or in filamentous form. To facilitate investigation of genetic factors important for its morphogenesis and pathogenicity, congenic α strains form were constructed. XL280 (α) was selected the background strain because robust ability to undergo morphological transition from The MAT allele sequenced JEC20 introgressed into generate pair strains. resulting then used test impact mating type on...
ABSTRACT Morphological switch is tightly coupled with the pathogenesis of many dimorphic fungal pathogens. Cryptococcus neoformans , major causative agent cryptococcal meningitis, mostly presents as yeast form but capable switching to hyphal form. The filamentous has long been associated attenuated virulence, yet underlying mechanism remains elusive. We previously identified master regulator Znf2 that controls yeast-to-hypha transition in . Activation promotes formation and abolishes...
In Arabidopsis, jasmonate (JA)-signaling plays a key role in mediating Fusarium oxysporum disease outcome. However, the roles of JASMONATE ZIM-domain (JAZ) proteins that repress JA-signaling have not been characterized host resistance or susceptibility to this pathogen. Here, we found most JAZ genes are induced following F. challenge, and screening T-DNA insertion lines Arabidopsis family members identified highly disease-susceptible JAZ7 mutant (jaz7-1D). This exhibited constitutive...
Understanding how fungi colonize the GI tract is increasingly recognized as highly relevant to human health. The animal models used study Candida albicans commensalism commonly rely on altering host microbiome (via antibiotic treatment or defined diets) establish successful colonization by C. reference isolate SC5314.
Treatment of multi-drug resistant (MDR) Escherichia coli intestinal infections are being hampered by the presence mcr-1 (colistin) and tet (tetracycline) resistance genes in these strains. We screened seven traditional Chinese medicines for their ability to synergize with tetracycline provide an effective new drug treatment animal diseases caused MDR E. coli. Our primary screen identified quercetin as a compound that reduced minimum inhibitory concentration (MIC) against standard test strain...
Copy number variations (CNVs) are an important source of genomic diversity that have been associated with drug resistance. We identify two unusual CNVs in the human fungal pathogen Candida parapsilosis .
Summary Pathogens target phytohormone signalling pathways to promote disease. Plants deploy salicylic acid ( SA )‐mediated defences against biotrophs. antagonize immunity by activating jasmonate signalling, for example Pseudomonas syringae pv. tomato DC 3000 produces coronatine COR ), a jasmonic JA ) mimic. This study found unexpected dynamics between , and co‐operation JAZ repressor proteins during infection. We used systems‐based approach involving targeted hormone profiling,...
Dendritic cells (DCs) can process the antigens of cancer vaccine and thus stimulate CD8