A5001284314- Cannabis and Cannabinoid Research
- Acute Kidney Injury Research
- Dental materials and restorations
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects and Toxicity Studies
- Renal Diseases and Glomerulopathies
- Dental Research and COVID-19
- Pancreatic function and diabetes
- Extracellular vesicles in disease
- Liver Disease Diagnosis and Treatment
- Dental Implant Techniques and Outcomes
- Diet, Metabolism, and Disease
- Epigenetics and DNA Methylation
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Glycation End Products research
- Autophagy in Disease and Therapy
- Cytomegalovirus and herpesvirus research
- Metabolism, Diabetes, and Cancer
- Hepatitis C virus research
- Viral Infections and Immunology Research
- Immunotherapy and Immune Responses
- Fatty Acid Research and Health
- Genetic and Kidney Cyst Diseases
- T-cell and B-cell Immunology
- Drug Transport and Resistance Mechanisms
Southern Medical University
2015-2025
Nanfang Hospital
2018-2025
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
Key Laboratory of Guangdong Province
2022-2024
Sun Yat-sen University
2018-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Chengdu University of Traditional Chinese Medicine
2024
Cellular senescence is associated with renal disease progression, and accelerated tubular cell promotes the pathogenesis of fibrosis. However, underlying mechanism unknown. We assessed potential role Wnt9a in Compared cells normal subjects, humans a variety nephropathies those several mouse models CKD expressed high levels that colocalized senescence-related protein p16 INK4A . expression level correlated extent fibrosis, decline eGFR, Furthermore, ectopic after ischemia-reperfusion injury...
Abstract Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney disease (CKD), suggesting intimate communication between two types cells. However, underlying mechanisms remain to be determined. Exosomes play a role in shuttling proteins other materials recipient In our study, we found that exosomes were aroused by β‐catenin renal tubular Osteopontin (OPN), especially its N‐terminal fragment (N‐OPN), was encapsulated β‐catenin‐controlled cell‐derived exosome...
Acute kidney injury (AKI) is in high prevalence worldwide but with no therapeutic strategies. Programmed cell death tubular epithelial cells has been reported to accelerate a variety of AKI, the major pathways and underlying mechanisms are not defined. Herein, we identified that pyroptosis was responsible for AKI progression related ATP depletion renal cells. We found FAM3A, mitochondrial protein assists synthesis, decreased negatively correlated both mice patients AKI. Knockout FAM3A...
Rationale: Renal fibrosis, with no therapeutic approaches, is a common pathological feature in various chronic kidney diseases (CKD).Tubular cell injury plays pivotal role renal fibrosis.Commonly, injured tubular cells exhibit significant lipid accumulation.However, the underlying mechanisms remain poorly understood.Methods: 2-arachidonoylglycerol (2-AG) levels CKD patients and model specimens were measured using mass spectrometry.2-AG-loaded nanoparticles infused into unilateral ureteral...
Acute kidney injury (AKI) is in rapid prevalence nowadays. Of note, the underlying mechanisms have not been clarified. Several reports showed a cluster of differentiation-44 (CD44), cell-surface glycoprotein, might be involved AKI. However, its role AKI has clearly Herein, we found CD44 increased renal tubules mice. Gene ablation improved mitochondrial biogenesis and fatty acid oxidation (FAO) function, further protecting against tubular cell death injury. Conversely, ectopic impaired...
Aflatoxin B1 (AFB1) is a potent immunosuppressive agent in endotherms, which can be related to the up-regulated apoptosis of immune organs. In this study, we investigated roles mitochondrial, death receptor, and endoplasmic reticulum pathways induced thymocytes apoptosis. Chickens were fed an aflatoxin containing diet (0.6 mg/kg AFB1) for 3 weeks. Our results showed that (1) AFB1 decrease T-cell subsets, morphological changes, excessive thymus. (2) The involved mitochondrial pathway...
Energy metabolism disorder, mainly exhibiting the inhibition of fatty acid degradation and lipid accumulation, is highly related with aging acceleration. However, intervention measures are deficient. Here, we reported Omega-3 polyunsaturated acids (Omega-3 PUFAs), especially EPA, exerted beneficial effects on maintaining energy homeostasis to slow organ aging. As endogenous agonist peroxisome proliferator-activated receptor α (PPARα), PUFAs significantly boosted β-oxidation ATP production in...
Renal fibrosis is a common feature in various chronic kidney diseases (CKD). Tubular cell damage main characterization which results from dysregulated fatty acid oxidation (FAO) and lipid accumulation. Cannabinoid Receptor 2 (CB2) contributes to renal fibrosis, however, its role FAO dysregulation tubular cells not clarified. In this study, we found CB2 plays detrimental metabolism cells.
The endocannabinoid system has multiple effects. Through interacting with cannabinoid receptor type 1 and 2, this can greatly affect disease progression. Previously, we showed that activated 2 (CB2) mediated kidney fibrosis. However, the underlying mechanisms remain underdetermined. Here, report CB2 was upregulated predominantly in tubular epithelial cells unilateral urinary obstruction ischemia-reperfusion injury models mice, patients a variety of diseases. expression closely correlated...
Chronic kidney disease (CKD) has a high prevalence worldwide. Renal fibrosis is the common pathological feature in various types of CKD. However, underlying mechanisms are not determined. Here, we adopted different CKD mouse models and cultured human proximal tubular cell line (HKC-8) to examine expression C-X-C motif chemokine receptor 4 (CXCR4) β-catenin signalling, as well their relationship renal fibrosis. In mice humans with variety nephropathies, CXCR4 was dramatically up-regulated...
Previous observational studies have suggested an important role of omega-3 in low back pain. In the present study, we used a two-sample Mendelian randomization (MR) study to identify putative causal link between and A broadly genome-wide association (GWAS) ( n = 8,866 individuals from European ancestry) was select plasma genetic instrumental variables (IVs). previously reported GWAS (4,863 cases 74,589 controls for pain were assess effect levels on MR-egger_intercept, MR-PRESSO, MR_egger,...
Background: Liver kinase B1 (LKB1) is the key regulator of energy metabolism and cell homeostasis.LKB1 dysfunction plays a role in renal fibrosis.However, LKB1 activators are scarce commercial nowadays.This study aims to discover new drug molecule, piericidin analogue S14 (PA-S14), preventing fibrosis as novel activator LKB1.Methods: Our group isolated PA-S14 from broth culture marine-derived Streptomyces strain identified its binding site.We adopted various CKD models or AKI-CKD model (5/6...
Valproic acid (VPA) is a first-line antiepileptic drug with broad efficacy. Due to significant individual differences in its metabolism, therapeutic monitoring commonly used. However, the recommended range (50–100 μg/mL) inadequate for predicting clinical outcomes. Additionally, relationship between VPA metabolites and outcomes remains unclear. In this retrospective study, 485 Chinese Southern Han epilepsy patients receiving monotherapy were analyzed after reaching steady-state levels....
A recent Mendelian randomization (MR) did not support an effect of the lead interleukin-6 receptor (IL-6 R) variant on risk pulmonary arterial hypertension (PAH). Thus, we used two sets genetic instrumental variants (IVs) and publicly available PAH genome-wide association studies (GWAS) to reassess causal link between IL-6 signaling PAH.Six independent 34 soluble (sIL-6 IVs from MR reports GWAS including 162,962 European individuals were perform this two-sample study.We found that as...
Abstract Podocyte injury is a hallmark of glomerular diseases; however, the underlying mechanisms remain unclear. B7-1 increased in injured podocytes, but its intrinsic role controversial. The clinical data here revealed intimate correlation urinary with severity injury. Through transcriptomic and biological assays transgenic adriamycin nephropathy models, we identified key mediator podocyte glomerulosclerosis through series signal transmission to β-catenin. Using LC-MS/MS, Hsp90ab1,...
Aging is an important risk factor for kidney injury. Energy homeostasis plays a key role in retarding aging, and mitochondria are responsible energy production. In the kidney, renal tubular cells possess high abundance of to meet consumption. AMPK evolutionarily conserved serine/threonine kinase which central maintaining mitochondrial homeostasis. Besides that, also commands autophagy, clearing recycling process maintain cellular However, effect activators on aging has not been fully...
Observational studies have suggested a suspected association between varicella-zoster virus (VZV) infection and multiple sclerosis (MS), but the connection has remained unclear. The aim of present study is to evaluate causal relationship chickenpox which caused by VZV MS. We performed two-sample Mendelian randomization analysis investigate with MS using summary statistics from genome-wide (GWAS). GWAS data for was 23andMe cohort including 107 769 cases 15 982 controls. A large statistical...
Abstract Kidney fibrosis, characterized by the activation and expansion of matrix-producing fibroblasts, is common outcome chronic kidney disease (CKD). While fibroblast proliferation well studied in CKD, little known about regulation mechanism depletion. Here, we show that exosomes derived from stressed/injured tubules play a pivotal role dictating apoptosis fate. When human tubular cells (HK-2) were stimulated with TGF-β1, they produced released increased amounts (TGFβ-Exo), which...
Viral myocarditis (VMC) is an inflammatory myocardial condition triggered by viral infections which involves pathogenic-related damage and immune-mediated damage. However, the precise immunopathogenic mechanisms underlying VMC remain elusive. We performed single-cell RNA sequencing on mouse hearts during acute phase of CVB3-induced VMC. After manually annotating cell types, functional analyses macrophage were ratio changes, customized gene set module scoring CellPhoneDB. Utilizing indirect...
Myocarditis is a common inflammatory heart disease in children and young adults, with fulminant myocarditis (FM) being the most severe form due to its rapid onset high mortality rate. However, precise pathological immune subsets molecular change myocarditis, particularly FM, remain unknown. We performed single-cell RNA sequencing of pediatric peripheral blood mononuclear cells during acute recovery phases FM. A viral (MC) mouse model was established using CVB3. Deletion adoptive transfer...
Aim Our Previous research revealed significant differences in exosome-mediated intercellular miR-425a-5p between normal children and those with fulminant myocarditis. We sought to elucidate the molecular underpinnings functional implications of context myocarditis progression. Methods Bioinformatics techniques were employed predict NRAS as target gene miR-425a-5p. constructed a cellular paradigm through LPS-mediated provocation AC16 cardiomyocyte cultures. MiR-425a-5p was overexpressed,...