A5074629340- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Cancer therapeutics and mechanisms
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- Cannabis and Cannabinoid Research
- Immune cells in cancer
- interferon and immune responses
- Metabolism, Diabetes, and Cancer
- PARP inhibition in cancer therapy
- Smart Grid and Power Systems
- Bone Metabolism and Diseases
- ATP Synthase and ATPases Research
- Osteoarthritis Treatment and Mechanisms
- Phagocytosis and Immune Regulation
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Nanopore and Nanochannel Transport Studies
- Synthesis and Characterization of Heterocyclic Compounds
- BRCA gene mutations in cancer
- Machine Learning in Materials Science
Chongqing Medical University
2025
Nanjing Medical University
2025
Wuhan University
2022-2025
Zhongnan Hospital of Wuhan University
2023-2025
Zhejiang University
2025
Henan University of Science and Technology
2025
Renmin Hospital of Wuhan University
2025
Tianjin University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2023-2024
Southern Medical University
2024
Rationale: Renal fibrosis, with no therapeutic approaches, is a common pathological feature in various chronic kidney diseases (CKD).Tubular cell injury plays pivotal role renal fibrosis.Commonly, injured tubular cells exhibit significant lipid accumulation.However, the underlying mechanisms remain poorly understood.Methods: 2-arachidonoylglycerol (2-AG) levels CKD patients and model specimens were measured using mass spectrometry.2-AG-loaded nanoparticles infused into unilateral ureteral...
Renal fibrosis is a common feature in various chronic kidney diseases (CKD). Tubular cell damage main characterization which results from dysregulated fatty acid oxidation (FAO) and lipid accumulation. Cannabinoid Receptor 2 (CB2) contributes to renal fibrosis, however, its role FAO dysregulation tubular cells not clarified. In this study, we found CB2 plays detrimental metabolism cells.
Abstract Background Discrepancies in the utilization of reactive oxygen species (ROS) between cancer cells and their normal counterparts constitute a pivotal juncture for precise treatment cancer, delineating noteworthy trajectory field targeted therapies. This phenomenon is particularly conspicuous domain nano-drug precision treatment. Despite substantial strides employing nanoparticles to disrupt ROS therapy, current strategies continue grapple with challenges pertaining efficacy...
Abstract As the world's first oral nuclear export inhibitor, selinexor is increasingly being used in clinical applications for malignant tumors. However, there no extensive exploration on selinexor's adverse events (ADEs), necessitating a real-word assessment of its medication safety. FAERS data (July 2019–June 2023) were searched ADE reports across all indications. Use system organ class (SOC) and preferred terms (PT) from medical dictionary regulatory activities (MedDRA) to describe,...
Background OASL (Oligoadenylate Synthetase-Like), an interferon-induced protein in the OAS family, plays a significant role anti-viral response. Studies have demonstrated its association with prognosis of certain tumors. However, mechanism through which affects tumors is unclear. A systemic pan-cancer study needs to be illustrated. Methods Analysis expression across 33 was conducted utilizing TCGA, GTEx and CPTAC databases. COX Log-Rank regressions were employed calculate prognosis. We...
OAS1(2'-5'-oligoadenylate synthetase 1) is a member of the Interferon-Stimulated Genes which plays an important role in antiviral process. In recent years, OAS1 tumors has attracted attention, and it was found to be associated with prognosis several tumors. However, mechanism by affects unclear pan-cancer study necessary better understand its implication cancers.The expression, prognostic value, genetic alteration, alternative splicing events pan-cancers were analyzed using TCGA, GTEx, HPA,...
Background: Elevated estrogen has been found to contribute the pathological development of endometrial cancer (EC), potentially through alterations in tumor inflammatory immune microenvironment. However, exact mechanisms underlying this process remain unclear. Methods: Bioinformatics was used identify differentially expressed genes, analyze pathway enrichment, and assess their correlation with cell infiltration. Ishikawa cells ECC-1 were stimulated estradiol (E2) or selective receptor...
Compared with the traditional gene expression techniques of quantitative analysis, RT-qPCR is most widely used because its low cost, time-saving, and accuracy. It essential to introduce suitable internal reference genes as corrections in experiments reduce RNA quality reverse transcription efficiency different samples. In our study, we chose candidate alfalfa from transcriptome sequence datasets (162 RNA-seq sequencing data) through comparative analysis. Finally, 10 were selected. These...
The development of morphine tolerance presents a major clinical challenge in the effective management severe pain. This study aims to explore mechanisms underlying from novel perspective, with ultimate goal uncovering new insights and identifying promising therapeutic targets for its treatment. C57BL/6J mice were used tail-flick test evaluate tolerance. Neutrophils derived mouse bone marrow employed investigate morphine-induced NETs formation. Bone marrow-derived macrophages (BMDMs)...
Dysregulation of extracellular matrix (ECM) homeostasis plays a pivotal role in the accelerated degradation cartilage, presenting notable challenge for effective osteoarthritis (OA) treatment and cartilage regeneration. In this study, we introduced an injectable hydrogel based on streamlined-zinc oxide (ZnO), which is responsive to metallopeptidase (MMP), delivery miR-17-5p. This approach aimed address damage by regulating ECM homeostasis. The ZnO/miR-17-5p composite functions releasing zinc...
N6-methyladenosine (m6A) methylation of RNA by the methyltransferase complex (MTC), with core components including METTL3-METTL14 heterodimers and Wilms' tumor 1-associated protein (WTAP), contributes to breast tumorigenesis, but underlying regulatory mechanisms remain elusive. Here, we identify a novel cleaved form METTL3a (residues 239-580 METTL3). We find that is required for METTL3-WTAP interaction, m6A deposition, as well cancer cell proliferation. Mechanistically, essential...
Mitochondria play essential roles in cancer cell adaptation to hypoxia, but the underlying mechanisms remain elusive. Through mitochondrial proteomic profiling, we here find that prolyl hydroxylase EglN1 (PHD2) accumulates on mitochondria under hypoxia. substrate-binding region β2β3 loop is responsible for its translocation and contributes breast tumor growth. Furthermore, identify AMP-activated protein kinase alpha (AMPKα) as an substrate mitochondria. The EglN1-AMPKα interaction their...
N 6 -methyladenosine (m A) methylation of RNA by the methyltransferase complex (MTC), with core components including METTL3–METTL14 heterodimers and Wilms’ tumor 1-associated protein (WTAP), contributes to breast tumorigenesis, but underlying regulatory mechanisms remain elusive. Here, we identify a novel cleaved form METTL3a (residues 239–580 METTL3). We find that is required for METTL3–WTAP interaction, m A deposition, as well cancer cell proliferation. Mechanistically, essential...
Acute liver failure (ALF) is a significant global issue with elevated morbidity and mortality rates. There an urgent pressing need for secure effective treatments. Ferroptosis, novel iron-dependent regulation of cell death, plays role in multiple pathological processes associated diseases, including ALF. Several studies have demonstrated that mesenchymal stem cells (MSCs) promising therapeutic potential the treatment This study aims to investigate positive effects MSCs against ferroptosis...
Abstract Ubiquitin-specific protease 1 (USP1), a well-characterized member of the deubiquitinating enzyme family, selectively cleaves ubiquitin from various target proteins, including DNA repair protein PCNA. USP1 contributes to oncogenesis by playing critical roles in damage processes translesion synthesis and Fanconi anemia pathway. Despite clinical benefit achieved with PARP inhibitors (PARPi) BRCA-mutated (BRCAm) or homologous recombination deficient (HRD+) populations, some patients...
Tranexamic acid is increasingly used to whiten skin, reverse dermal damages, and treat heavy menstrual bleeding in young women. However, its potential toxicity mammalian oocytes still unclear. Our study revealed that tranexamic exposure impaired the mouse oocyte quality subsequent embryo development. Meanwhile, melatonin has been found exert beneficial effects reducing acid-induced mitochondrial dysfunction oxidative stress.
Abstract N 6 -methyladenosine (m A) methylation of RNA by the methyltransferase complex (MTC), with core components including METTL3-METTL14 heterodimers and Wilms’ tumor 1-associated protein (WTAP), contributes to breast tumorigenesis, but underlying regulatory mechanisms remain elusive. Here, we identify a novel cleaved form METTL3a (residues 239-580 METTL3). We find that is required for METTL3-WTAP interaction, m A deposition, as well cancer cell proliferation. Mechanistically, essential...
N6-methyladenosine (m6A) methylation of RNA by the methyltransferase complex (MTC), with core components including METTL3-METTL14 heterodimers and Wilms’ tumor 1-associated protein (WTAP), contributes to breast tumorigenesis, but underlying regulatory mechanisms remain elusive. Here, we identify a novel cleaved form METTL3a (residues 239-580 METTL3). We find that is required for METTL3-WTAP interaction, m6A deposition, as well cancer cell proliferation. Mechanistically, essential...