A5100439404- Pain Mechanisms and Treatments
- Hepatitis B Virus Studies
- Neuroscience and Neuropharmacology Research
- Liver Disease Diagnosis and Treatment
- Congenital Heart Disease Studies
- Animal Nutrition and Physiology
- Pharmacological Effects of Natural Compounds
- Hepatitis C virus research
- Hemoglobinopathies and Related Disorders
- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Tracheal and airway disorders
- Ubiquitin and proteasome pathways
- Plant Molecular Biology Research
- Amino Acid Enzymes and Metabolism
- Biochemical effects in animals
- Hepatitis Viruses Studies and Epidemiology
- Sugarcane Cultivation and Processing
- Plant Stress Responses and Tolerance
- MicroRNA in disease regulation
- Congenital Diaphragmatic Hernia Studies
- Natural Products and Biological Research
- Retinopathy of Prematurity Studies
Shanghai Public Health Clinical Center
2015-2025
Guangxi Maternal and Child Health Hospital
2014-2025
Nanjing Forestry University
2025
Capital Medical University
2022-2024
Shanghai Jiao Tong University
2013-2024
Huazhong University of Science and Technology
2014-2024
Guangxi Zhuang Autonomous Region Health and Family Planning
2024
Xian Central Hospital
2024
Shanghai Sixth People's Hospital
2024
East China Normal University
2024
Highlights•Molecularly defined and functionally distinct D28K+ D28K− subnetworks•D28K+ subnetworks differ in morphological physiological properties•D28K+ → VPNs cholinergic subnetwork controls anxiety-like behaviors via Kcnh1•D28K− DGNs encodes spatial memory Cacna1hSummaryCholinergic neurons the medial septum (MS) constitute a major source of input to forebrain modulate diverse functions, including sensory processing, memory, attention. Most studies date have treated as single population;...
Background: Hypoxia is a hallmark of the physical microenvironment solid tumors. As key factor that regulates tumor development and progression, hypoxia can reprogram expression multiple genes, whose biological function molecular mechanism in cancer remain largely unclear. The mitochondrial ribosome protein family consists nuclear-encoded proteins are responsible for synthesis mitochondria. Methods: A high-throughput RNA sequencing assay was carried out to identify differentially expressed...
The gamma-glutamyl-transpeptidase to platelet ratio (GPR) is a new liver fibrosis model, which reported be more accurate than aspartate transaminase (AST) index (APRI) and based on the four factors (Fib-4) for diagnosing significant cirrhosis in patients with chronic hepatitis B (CHB) West Africa. aim of this study assess diagnostic accuracy GPR Chinese CHB patients, explore whether deserves popularized China. A total 372 who underwent biopsies routine laboratory tests were retrospectively...
Abstract Background Cinobufagin is the major bufadienolide of Bufonis venenum (Chansu), which has been traditionally used for treatment chronic pain especially cancer pain. The current study aimed to evaluate its antinociceptive effects in bone and explore underlying mechanisms. Methods Rat model was this study. withdrawal threshold evoked by stimulation hindpaw determined using a 2290 CE electrical von Frey hair. β-endorphin IL-10 levels were measured spinal cord cultured primary microglia,...
Abstract AURKA is a potential kinase target in various malignancies. The kinase‐independent oncogenic functions partially disclose the inadequate efficacy of inhibitor Phase III clinical trial. Simultaneously targeting catalytic and noncatalytic may be feasible approach. Here, set proteolysis chimeras (PROTACs) are developed. CRBN‐based dAurA383 preferentially degrades highly abundant mitotic AURKA, while cIAP‐based dAurA450 lowly interphase acute myeloid leukemia (AML) cells. proteomic...
Abstract The clinical application of ferroptosis, characterized by iron‐dependent lipid peroxidation, is limited because the serious side effects using toxic‐dose iron. Herein, a polyvalent ferroptosis agonist‐a hypoxia responsive polymer bearing 18‐crown‐6 ring (hPPAA18C6) developed. In contrast to natural agonists (erastin, RSL3, and sorafenib), hPPAA18C6 stimulates releasing endogenous iron stored in “iron pools” cellular organelles depleting glutathione (GSH) via benzoquinone generated...
Abstract Background Discrepancies in the utilization of reactive oxygen species (ROS) between cancer cells and their normal counterparts constitute a pivotal juncture for precise treatment cancer, delineating noteworthy trajectory field targeted therapies. This phenomenon is particularly conspicuous domain nano-drug precision treatment. Despite substantial strides employing nanoparticles to disrupt ROS therapy, current strategies continue grapple with challenges pertaining efficacy...
AimsRecombinant human neuregulin-1 (rhNRG-1) improves cardiac function in experimental heart failure models, but the underlying mechanism remains largely unknown. In this study, we evaluated whether rhNRG-1 could improve via myosin light chain kinase/myosin 2 ventricular (cMLCK/MLC-2v) pathway rats with myocardial infarction (MI).
We have found that mutation of d-amino acid oxidase (DAO) diminished formalin-induced tonic pain. The present research further studied the analgesic effects a series DAO inhibitors in this model. 5-Chlorobenzo[d]isoxazol-3-ol (CBIO), 4<i>H</i>-thieno[3,2-b]pyrrole-5-carboxylic (compound 8), 5-methylpyrazole-3-carboxylic (AS057278), sodium benzoate, and 4-nitro-3-pyrazole carboxylic (NPCA) inhibited rat spinal cord-derived activity concentration-dependent manner, with maximal inhibition 100%...
ABSTRACT Hepatitis B virus (HBV) has extremely restricted host and hepatocyte tropism. HBV-based vectors could form the basis of novel therapies for chronic hepatitis other liver diseases would also be invaluable study HBV infection. Previous attempts at developing encountered low yields recombinant viruses and/or lack sufficient infectivity/cargo gene expression in primary hepatocytes, which hampered follow-up applications. In this work, we constructed a vector based on naturally occurring,...
Morphine is one of the most effective analgesics in medicine. However, its use associated with development tolerance and dependence. Recent studies demonstrating epigenetic changes brain after exposure to opiates have provided insight into mechanisms possibly underlying addiction. In this study, we sought identify ten regions rat following acute chronic morphine exposure. We analyzed DNA methylation six nuclear-encoded genes implicated function (Bdnf, Comt, Il1b, Il6, Nr3c1, Tnf) three...
Excitatory pyramidal neurons in the entorhinal cortical layer II region (ECII PN ) form functional excitatory synapses with CA1 parvalbumin inhibitory (CA1 PV and undergo selective degeneration early stages of Alzheimer's disease (AD). Here, we show that death-associated protein kinase 1 (DAPK1) is selectively activated ECII AD mice. Inhibition DAPK1 by deleting a catalytic domain or death rescues -CA1 synaptic loss improves spatial learning memory This study demonstrates activation...
Drug-coated balloon (DCB) angioplasty and drug-eluting stents (DES) are two widely used treatments for in-stent restenosis (ISR). Focal non-focal types of ISR affect the clinical outcomes. The present study aims to compare DES reimplantation versus DCB in acute coronary syndrome (ACS) patients with focal lesions.
Abstract Objective To construct Z ‐score reference ranges for normal fetal heart sizes throughout pregnancy. Methods This is a prospective cross‐sectional investigation of 809 singleton fetuses from 11th week to term. Fetal transverse diameter (HD), length (HL), circumference (HC) and area (HA) were derived two‐dimensional echocardiography. The regression analyses the mean ( M ) standard deviation (SD) each parameter calculated separately, using somatic as independent variables. A group...
In vitro experiments using rodent skeletal muscle cells suggest that neuregulin 1 (NRG1) is involved in glucose metabolism regulation, although no study has evaluated the role of NRG1 systemic homeostasis. The purpose this was to investigate effect chronic and acute treatment on homeostasis db/db mice. To aim, tolerance tests were performed 8-week-old male mice after with (50μg.kg-1) or saline 3 times per week for 8 weeks. other experiments, pyruvate 15 minutes a single injection. Liver,...
Abstract Bulleyaconitine (BAA) has been shown to possess antinociceptive activities by stimulation of dynorphin A release from spinal microglia. This study investigated its underlying signal transduction mechanisms. The data showed that (1) BAA treatment induced phosphorylation CREB (rather than NF-κB) and prodynorphin expression in cultured primary microglia, antiallodynia neuropathy, which were totally inhibited the inhibitor KG-501; (2) upregulated p38 (but not ERK or JNK), SB203580 JNK...