A5100375639- Molecular Sensors and Ion Detection
- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Metal-Organic Frameworks: Synthesis and Applications
- Sulfur Compounds in Biology
- Advanced biosensing and bioanalysis techniques
- Mass Spectrometry Techniques and Applications
- Nanoplatforms for cancer theranostics
- Electrochemical sensors and biosensors
- Luminescence and Fluorescent Materials
- Crystallization and Solubility Studies
- Mesoporous Materials and Catalysis
- Advanced Nanomaterials in Catalysis
- Textile materials and evaluations
- RNA modifications and cancer
- X-ray Diffraction in Crystallography
- Cancer, Hypoxia, and Metabolism
- Lanthanide and Transition Metal Complexes
- MicroRNA in disease regulation
- Microfluidic and Capillary Electrophoresis Applications
- Plant Physiology and Cultivation Studies
- Plant Molecular Biology Research
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- Covalent Organic Framework Applications
Lanzhou University
2016-2025
Ningxia Medical University
2024-2025
Capital Medical University
2025
Yangtze University
2024-2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2022-2025
University of Saskatchewan
2016-2025
Hebei Agricultural University
2020-2024
Central Hospital of Zibo
2024
Central South University
2008-2024
Chongqing Medical University
2024
The near-infrared (NIR) fluorescence sensor for rapid, selective, and sensitive detection of cystenine (Cys) is great importance in both biological environmental sciences. Herein, we report a specific probe with turn-on property, visible color change naked-eye, large wavelength shift on UV spectra highly selective Cys over homocysteine (Hcy) glutathione (GSH) HEPES buffer (10 mM, pH 7.4) diluted human serum. based the conjugate addition–cyclization reaction has low limit to (0.16 μM as NIR...
Hydrazine has been applied diffusely in most of the chemical industry; however, it is a hazardous environmental pollutant and highly toxic to organisms. Selective, rapid, sensitive detection hydrazine thus becomes absolutely necessary both biological sciences. Accordingly, fluorescence probes for have paid great attention recent years. Disclosed here near-infrared (NIR) probe with turn-on fluorescent CyJ based on structure–emission property relationships NIR dyes containing an acetyl group...
Abstract Purpose: The serine-threonine kinase mammalian target of rapamycin has emerged as a potential for cancer therapy. Rapamycin and analogs are undergoing clinical trials have induced responses in subgroup patients. also been reported to enhance the efficacy several cytotoxic agents. aim this study was determine nature interactions between chemotherapeutic agents used first- second-line against breast cancer. Experimental Design: We performed multiple drug effect/combination index...
Abstract Purpose: Rapamycin inhibits the serine-threonine kinase mammalian target of rapamycin (mTOR), blocking phosphorylation p70 S6 (S6K1) and 4E-binding protein 1 (4E-BP1) inhibiting translation cell cycle progression. its analogues are currently being tested in clinical trials as novel-targeted anticancer agents. Although show activity trials, only some treated patients respond. The purpose this study is to identify determinants sensitivity that may assist selection appropriate for...
Thiol-stabilized Au(25)L(18) monolayer protected clusters (MPCs) were found to be active for the reduction of 4-nitrophenol. Results suggest that these MPCs are stable catalysts and do not lose their structural integrity during catalytic process. High stability under reaction conditions enables recyclability MPCs.
A novel near-infrared (NIR), turn-on fluorescence probe<bold>CyR</bold>containing a phosphinate group as recognizing moiety for the selective detection of O<sub>2</sub>˙<sup>−</sup>with low limit (LOD, 9.9 nM) was developed.
The issues related to the oxygen reduction efficiency and CO2 endurance pose challenges achieving efficient electrochemical energy conversion in solid oxide fuel cells. Here, we develop an effective strategy using only Cu doping boost kinetics durability of NdBa0.5Sr0.5Co2O5+δ (NBSC). By introducing ions into Co sites (NBSC) lattice, concentration vacancies as well ratio Co3+/Co4+ can be effectively controlled. Consequently, charge transfer dissociation during ORR process, average bonding...
Liquid chromatography-multiple reaction monitoring mass spectrometry of peptides using stable isotope dilution (SID) provides a powerful tool for targeted protein quantitation. However, the high cost labeled peptide standards SID poses an obstacle to multiple studies. We compared reference (LRP) method, which uses single as standard all measured peptides, and label-free (LF) approach, in quantitation is based on analysis un-normalized peak areas detected MRM transitions. analyzed from...
Human osteosarcoma harbors a small subpopulation of cancer stem cells (CSCs) that is believed to be associated with tumor metastasis, radioresistance/chemoresistance, local invasion, and poor clinical outcome. In this study, we found transforming growth factor β1 (TGF-β1) signaling hypoxic environment dramatically induced self-renewal capacity in non-stem cells, which turn promoted chemoresistance, tumorigenicity, neovasculogenesis, metastatic potential. Furthermore, blocking the TGF-β1...
Shotgun proteomics provides the most powerful analytical platform for global inventory of complex proteomes using liquid chromatography−tandem mass spectrometry (LC−MS/MS) and allows a analysis protein changes. Nevertheless, sampling by current shotgun platforms is incomplete, this contributes to variability in assessment peptide inventories spectral counting approaches. Thus, data pose challenges comparing from different biological states. We developed an strategy quasi-likelihood...