Glucocorticoids (GCs) show powerful treatment effect on rheumatoid arthritis (RA). However, the clinical application is limited by their nonspecific distribution after systemic administration, serious adverse reactions during long-term administration. To achieve better treatment, reduce side effect, we here established a biomimetic exosome (Exo) encapsulating dexamethasone sodium phosphate (Dex) nanoparticle (Exo/Dex), whose surface was modified with folic acid (FA)-polyethylene glycol...

Infection and healing of wounds after injury has always been an unavoidable problem in daily life, so design a biomaterial with antibacterial good wound properties is highly needed. Herein, hydrogel dressing halloysite clay chitin as the main components was prepared, which combines advantages biomacromolecule clay. Halloysite nanotubes (HNTs) are extremely biocompatible materials hollow tubular structure, inner outer surfaces HNTs composed SiOx AlOx layers different charges. Au nanoparticles...

Radiation colitis is the leading cause of diarrhea and hematochezia in pelvic radiotherapy patients. This work advances pathogenesis radiation from perspective ferroptosis. An oral Pickering emulsion stabilized with halloysite clay nanotubes to alleviate by inhibiting Ceria nanozyme grown situ on can scavenge reactive oxygen species, deferiprone was loaded into lumen relieve iron stress. These two strategies effectively inhibit lipid peroxidation rescue ferroptosis intestinal...

Abstract Uncontrollable bleeding from military conflicts, accidents, and surgical procedures is a major life‐threatening factor. Rapid, safe, convenient hemostasis critical to the survival of patients in prehospital care. However, peel‐off hemostats such as kaolinite sheets cotton fibers often poses risk distal thrombosis. Here, an efficient clay hemostat halloysite nanotubes tightly bound onto commercial fibers, which capillary mediated by biopolymer alginate with Ca 2+ crosslinking. The...

Background Gallium 68–labeled fibroblast-activation protein inhibitor (68Ga-FAPI), an imaging agent for detecting tumors, represents a promising alternative to fluorine 18 fluorodeoxyglucose (18F-FDG). Purpose To compare the potential efficacy of 68Ga-FAPI PET/CT with that 18F-FDG primary tumor and nodal distant metastases in biliary tract cancer (BTC) explore impact (tumor staging) compared on clinical management BTC. Materials Methods This single-center prospective study was performed at...

Bone metastases of malignant tumors significantly threaten the patient survival and quality life. We designed synthesized a novel bisphosphonate radiopharmaceutical [68Ga- or 177Lu-labeled DOTA-Ibandronate(68Ga/177Lu-DOTA-IBA)] for targeted diagnosis treatment bone metastases. This study explored basic biological characteristics 177Lu-DOTA-IBA, guiding clinical translation providing evidence future applications. The control variable method was used to optimize optimal labeling conditions. in...

Abstract UV radiation is the main cause of skin aging and cancers. Commercial sunscreens suffer from low efficacy poor safety, while ceria nanocrystals are promising inorganic filters. Herein, lumen natural halloysite clay nanotubes (HNTs) employed for confined growth nanocrystals, which can effectively tailor particle size, morphology, distribution, oxygen vacancies ceria. The in HNTs exhibits increased protection catalytic activity, outer surfaces be retained additional modification....

We designed and synthesized a novel theranostic bisphosphonate radiopharmaceutical ( 68 Ga- or 177 Lu-labeled DOTA-ibandronic acid [ Ga/ Lu-DOTA-IBA]) for bone metastasis. In this study, the dosimetry, safety, efficacy of Lu-DOTA-IBA as metastases were evaluated in patients with malignancy based on images, blood samples, dosimetric analysis.Eighteen metastasis progression under conventional therapies included study. Baseline 99m Tc-MDP SPECT Ga-DOTA-IBA PET/CT performed comparative purposes...

The synthesis of enantiopure homochiral metal-organic frameworks (MOFs) based on achiral materials is highly appealing. Due to their chiral properties and separation capabilities, MOF membranes have garnered significant attention....

Currently, fluorine-18-fluorodeoxyglucose ( 18 F-FDG) is the most frequently used diagnostical radiotracer for PET/computed tomography (PET/CT) in ovarian malignancies. However, F-FDG has some limitations. The fibroblast activation protein inhibitor (FAPI) previously demonstrated highly promising results studies on various tumor entities and 68 Ga-labeled FAPI presents a alternative to F-FDG. This study aimed compare performance of Ga-FAPI PET/CT imaging malignancies.A total 27 patients were...

Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts, making it an attractive target for both imaging and therapy of malignancy. This study presents a range novel FAP inhibitors derived from amino derivatives UAMC1110, incorporating polyethylene glycol bulky groups containing bifunctional DOTA chelators. The compounds labeled with gallium-68 were developed characterized to biodistribution properties tumor-targeting performance nude mice bearing U87MG tumor...

The purpose of this study was to develop a novel drug delivery system for sustained and targeted honokiol (HK) the nasopharyngeal carcinoma (NPC) HNE-1 cell lines, since folate receptor (FR) is over-expressed on their surface. Emulsion solvent evaporation used active targeting nanoparticles-loaded HK (ATNH) using copolymerpoly (ɛ-caprolactone)-poly (ethyleneglycol)-poly (ɛ-caprolactone) (PCEC), which modified with (FA) by introducing Polythylenimine (PEI). ATNH characterization, including...

Background Gallium 68 (68Ga)-labeled fibroblast activation protein inhibitor (FAPI) is of great diagnostic value for intrahepatic tumors. However, cirrhosis may lead to increased 68Ga-FAPI uptake in background liver, affecting the ability 68Ga-FAPI. Purpose To assess effect on liver parenchyma and tumor compare fluorine 18 (18F)-labeled fluorodeoxyglucose (FDG) PET/CT depict tumors patients with cirrhosis. Materials Methods In this secondary analysis a prospective trial, who underwent both...

In order to achieve the purpose of targeting treatment osteosarcoma, we developed novel paclitaxel (PTX) nanoparticles (Nps) coated with polydopamine (PDA) and grafted by alendronate (ALN) as ligand. Dopamine can be easily polymerized on various surfaces form a thin PDA film in alkaline environment, which provided versatile platform perform secondary reactions for compounds without functional groups. The Nps had mean particle size 290.6 ± 2.2 nm zeta potential -13.4 2.7. It was stable...

Abstract Circularly polarized luminescence (CPL) holds great potential for next‐generation display techniques. However, dynamic, multicolor CPL with high luminescent quantum yield (PLQY) and tunable dissymmetry factor ( g lum ) based on cost‐effective, sustainable materials is scarcely attainable. Herein, a straightforward approach proposed engineering cellulose nanocrystal (CNC) chiral superstructures loaded aggregation‐induced emission luminogens (AIEgens) through the evaporation‐induced...

18 F-Flortaucipir, as a classical Tau protein visualizer, has been widely used in the diagnosis of neurodegenerative diseases, especially Alzheimer disease. This report describes case intense uptake F-Flortaucipir at 2 sites reduced bone mineral density skull, but no radioactivity was seen on F-FDG and F-Florbetapir PET/CT imaging same lesion sites. The mechanism behind focal osteopenia remains unclear. study provides evidence for above phenomenon.

To investigate the metabolic characteristics of 18F-fluorodeoxyglucose (18F-FDG) in myeloid leukemia by vitro culture cells and construction tumor-bearing nude mouse model. U937, THP-1, HL60 K562 were cultured vitro. The logarithmic growth phase (l×10 5 cells/well) added with 18F-FDG, uptake rate 18F-FDG was measured at 15, 30, 60 120 min after addation, respectively. four kinds inoculated subcutaneously into hind limbs mice to establish a When tumor size about 500 mm3, injected through tail...