A5100319047- Corneal Surgery and Treatments
- Extracellular vesicles in disease
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Photoacoustic and Ultrasonic Imaging
- Pluripotent Stem Cells Research
- Monoclonal and Polyclonal Antibodies Research
- Advanced MRI Techniques and Applications
- Retinopathy of Prematurity Studies
- Cardiac pacing and defibrillation studies
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Optical Imaging and Spectroscopy Techniques
- Circular RNAs in diseases
- Tissue Engineering and Regenerative Medicine
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Cardiac Arrhythmias and Treatments
- Glaucoma and retinal disorders
- Cardiac Imaging and Diagnostics
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
Guangzhou Medical University
2025
Jiangnan University
2025
RMIT University
2023-2025
Nanyang Normal University
2024-2025
North China University of Science and Technology
2025
Chinese Academy of Sciences
2018-2024
Nanjing Medical University
2012-2024
Southwest Medical University
2020-2024
Anyang Institute of Technology
2023-2024
Northwest University
2019-2024
Exosomes, also known as extracellular vesicles, are naturally occurring, biocompatible, and bioacive nanoparticles ranging from 40 to 150 nm in diameter. Bone-secreted exosomes play important roles bone homeostasis, the interruption of which can lead diseases such osteoporosis, rheumatoid arthritis, osteopetrosis. Though relationship between vascular homeostasis has been recognized recently, role endothelial cell (EC)-secreted (EC-Exos) is not well understood. Herein, we found that EC-Exos...
Glucocorticoids (GCs) show powerful treatment effect on rheumatoid arthritis (RA). However, the clinical application is limited by their nonspecific distribution after systemic administration, serious adverse reactions during long-term administration. To achieve better treatment, reduce side effect, we here established a biomimetic exosome (Exo) encapsulating dexamethasone sodium phosphate (Dex) nanoparticle (Exo/Dex), whose surface was modified with folic acid (FA)-polyethylene glycol...
Neuroinflammation is a crucial factor in the development of secondary brain injury after intracerebral hemorrhage (ICH). Irisin newly identified myokine that confers strong neuroprotective effects experimental ischemic stroke. However, whether this can exert neuroprotection ICH remains unknown. This study aimed to investigate impact irisin treatment on neuroinflammation and neuronal apoptosis underlying mechanism involving integrin αVβ5/AMPK pathway ICH.Two hundred eighty-five adult...
Abstract Objective To assess whether intra-arterial tenecteplase administered after successful endovascular recanalisation improves outcomes in patients with acute arterial occlusion of the posterior circulation. Design Multicentre randomised controlled trial. Setting 31 hospitals China, 24 January 2023 to August 2023. Participants 208 (grade 2b50-3 on extended thrombolysis cerebral infarction scale) an V4 segment vertebral artery; proximal, middle, or distal basilar P1 artery: 104 were...
Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress. However, it unclear whether loss these ubiquitously important fully explains the cell lineage-specific tumorigenesis. In vitro studies implicate elimination R-loops, DNA-RNA hybrid structures involved transcription genetic instability. Here we show that R-loops accumulate preferentially...
Background: Cerebral ischemia-reperfusion (I/R) injury can lead to severe dysfunction, and its treatment is difficult. It reported that nucleotide-binding domain leucine-rich repeat family protein 3 (NLRP3) inflammasome-mediated cell pyroptosis an important part of cerebral I/R the activation autophagy inhibit in some tissue injury. Our previous study found protective effects bone marrow mesenchymal stem cells (BMSCs) may be associated with regulation autophagy. Recent studies have...
Abstract While the BA.2.86 variant demonstrated significant antigenic drift and enhanced ACE2 binding affinity, its ability to evade humoral immunity was relatively moderate compared dominant strains like EG.5 HK.3. However, emergence of a new subvariant, JN.1 (BA.2.86.1.1), which possesses an additional spike mutation, L455S, BA.2.86, showed markedly increased prevalence in Europe North America, especially France. Here, we found that L455S significantly enhances immune evasion capabilities...
The prevalence of retinal degenerative diseases, including age-related macular degeneration and retinitis pigmentosa, has been increasing globally is linked to the aging population improved life expectancy. These diseases are characterized by chronic, progressive neuronal damage or depletion photoreceptor cells in retina, limited effective treatment options currently available. Mesenchymal stem cell-derived exosomes (MSC-EXOs) containing cytokines, growth factors, lipids, mRNA, miRNA, which...
Objectives The formation of biofilm around implants, which is induced by immediate bacterial colonization after installation, the primary cause post-operation infection. Initial surface modification usually required to incorporate antibacterial agents on titanium (Ti) surfaces inhibit formation. However, simple and effective priming methods are still lacking for development an initial functional layer as a base subsequent coatings surfaces. purpose our work was establish novel Ti using...
Abstract Ciliary neurotrophic factor (CNTF), a well-known neuroprotective cytokine, has been found to play an important role in neurogenesis and functional regulations of neural stem cells. As one the most innervated tissue, however, CNTF cornea epithelium remains unclear. This study was explore roles mechanisms activation corneal epithelial stem/progenitor cells wound healing both normal diabetic mouse epithelium. In mice subjecting mechanical removal epithelium, cell were promoted by...
Introduction Senecavirus A (SVA) is a highly contagious virus that causes vesicular disease in pigs. At present, laboratory detection methods, such as isolation and polymerase chain reaction (PCR), required precision instruments qualified personnel, making them unsuitable for point-of-care tests (POCT). Fortunately, the emergence of CRISPR/Cas system has provided new opportunities fast efficient pathogen detection. Methods This study successfully developed precise sensitive platform...
Eosinophil differentiation factor (EDF) is a recently described regulator affecting eosinophil growth and activation. cDNA clones for murine EDF were isolated by direct expression from libraries prepared the T cell hybrid NIMP‐TH1. The longest clone obtained was 1534 bp in length encoding polypeptide of 133 amino acids. Two variant cDNAs suggesting alternative RNA processing events detected. gene cloned genomic λ library region 6727 encompassing sequenced. contains three introns 829, 1875 79...
Vascular endothelial dysfunction is the closely related determinant of ischemic heart disease (IHD). Endothelial and ischemia/reperfusion injury (IRI) have been associated with an increase in microvesicles (MVs) vivo. However, potential contribution (EMVs) to myocardial damage unclear. Here we aimed investigate role EMVs derived from hypoxia/reoxygenation (H/R) -treated human umbilical vein cells (HUVECs) on cultured H9c2 cardiomyocytes. H/R model was established induce HUVECs release...
A series of Ln-MOFs with π-conjugated and uncoordinated lewis basic triazolyl ligand have luminescence modulation, near white light emission, selective sensing, anticounterfeiting.
To study post-interventional findings in patients with dysthyroid optic neuropathy (DON) treated teprotumumab.In this multicenter observational Case series, DON were teprotumumab, an insulin-like growth factor I receptor inhibitor (10 mg/kg for the first infusion then 20 subsequent infusions, every three weeks a total 8 infusions). This included acute and chronic thyroid eye disease (TED) who had failed conventional therapies not candidates surgical decompression. Data collected best...
Methotrexate (MTX) has been highlighted for Rheumatoid arthritis (RA) treatment, however, MTX does not accumulate well at inflamed sites, and long-term administration in high doses leads to severe side effects. In this study, a novel anti-RA nanoparticle complex was designed constructed, which could improve the targeted accumulation joints reduce effects.Here, we prepared pH-sensitive biomimetic drug delivery system based on macrophage-derived microvesicle (MV)-coated zeolitic imidazolate...
Mesenchymal stem cells have neuroprotective effects that limit damage to the retina and photoreceptors, which may be mediated by extracellular vesicles (or exosomes) released mesenchymal cells. To investigate effect of derived from umbilical cord on glaucoma, we established rat models chronic ocular hypertension injecting conjunctival fibroblasts into anterior chamber mimic optic nerve injury caused glaucoma. One week after injury, cord-derived were injected vitreous cavity. We found...