A5101958291- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Medicinal Plants
- Cerebrovascular and Carotid Artery Diseases
- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- interferon and immune responses
- Bone Metabolism and Diseases
- Chronic Kidney Disease and Diabetes
- Peripheral Artery Disease Management
- Natural product bioactivities and synthesis
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Medicinal Plants and Bioactive Compounds
- Retinal and Optic Conditions
- Viral Infections and Immunology Research
- Metabolomics and Mass Spectrometry Studies
- Cancer-related molecular mechanisms research
- Eicosanoids and Hypertension Pharmacology
- Traumatic Brain Injury and Neurovascular Disturbances
- Plant-based Medicinal Research
- Gut microbiota and health
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Medicinal Plants
Xijing Hospital
2016-2025
University of Science and Technology of China
2021-2025
Air Force Medical University
2016-2025
Inner Mongolia Medical University
2018-2024
China Agricultural University
2020-2024
Ministry of Agriculture and Rural Affairs
2024
Xuzhou Medical College
2024
82th Hospital of Pla
2020-2023
Qingdao University
2023
Ministry of Natural Resources
2022-2023
Data from trials investigating the effects and risks of endovascular thrombectomy for treatment stroke due to basilar-artery occlusion are limited.
It has been reported that the PI3K/AKT signaling pathway plays a key role in pathogenesis of ischemic stroke. As result, development drugs targeting attracted increasing attention from researchers. This article reviews pathological mechanisms and advancements research related to pathways stroke, with focus on pathway. The findings include following: (1) complex stroke can be categorized into five major types: excitatory amino acid toxicity, Ca 2+ overload, inflammatory response, oxidative...
Abstract Objective To assess whether intra-arterial tenecteplase administered after successful endovascular recanalisation improves outcomes in patients with acute arterial occlusion of the posterior circulation. Design Multicentre randomised controlled trial. Setting 31 hospitals China, 24 January 2023 to August 2023. Participants 208 (grade 2b50-3 on extended thrombolysis cerebral infarction scale) an V4 segment vertebral artery; proximal, middle, or distal basilar P1 artery: 104 were...
Recently, two multicenter randomized controlled trials (RCT) failed to show a significantly beneficial effect of endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO). However, both suffered from equipoise issues which may have hindered the validity trial results. Therefore, additional RCT studies are needed explore potential benefit EVT presenting BAO.ATTENTION is an investigator-initiated, multicenter, prospective, randomized, clinical open-label and blinded...
Although strides have been made, the challenge of preventing and treating ischemic stroke continues to persist globally. For thousands years, natural substances Frankincense Myrrh employed in Chinese Indian medicine address cerebrovascular diseases, with key components 11-keto-β-boswellic acid (KBA) Z-Guggulsterone (Z-GS) being active agents. In this study, synergistic effect underlying mechanism KBA Z-GS on were examined using single-cell transcriptomics. Fourteen cell types identified...
Recently, a randomized controlled trial showed beneficial effect of intra-arterial thrombolysis following successful endovascular thrombectomy (EVT) in patients with acute ischemic stroke due to large vessel occlusion the anterior circulation. Due differences response thrombolytics posterior circulation, purpose ATTENTION IA is explore adjunct benefit after recanalization presenting and medium circulation.ATTENTION-IA an investigator-initiated, multicenter, prospective, clinical open-label...
Numerous references made clear that Triphala is revered as a multiuse therapeutic and perhaps even panacea historically. Nevertheless, the protective mechanism of on cardio-cerebral vascular diseases (CCVDs) remains not comprehensive understanding. Hence, network pharmacology-based method was suggested in this study to address problem. This based pharmacology bioinformatics analysis. Information compounds herbal medicines formula acquired from public databases. Oral bioavailability well...
Sleep disorder has become a prevalent issue in current society and is connected with the deterioration of neurobehaviors such as mood, cognition memory.Ellagic acid (EA) phenolic phytoconstituent extracted from grains fruits that potent neuroprotective properties.This research aimed to study alleviative effect mechanism EA on memory impairment anxiety caused by sleep deprivation (SD).EA ameliorated behavioral abnormalities SD mice, associated increased dendritic spine density, reduced...
New approaches are urgently needed to fight influenza viral infection. Previous research has shown that zirconia nanoparticles can be used as anticancer materials, but their antiviral activity not been reported. Here, we investigated the effect of (ZrO2) (NPs) against a highly pathogenic avian virus.In this study, effects ZrO2 on H5N1 virus were assessed in vivo, and molecular mechanism responsible for protection was investigated.Mice treated with 200 nm positively-charged NPs at dose 100...
Resveratrol is a natural polyphenol in lots of foods and traditional Chinese medicines, which has shown promising treatment for neurodegenerative diseases (NDs). However, the molecular mechanisms its action have not been systematically studied yet. In order to elucidate network pharmacological prospective effects resveratrol on NDs, we assessed pharmacokinetics (PK) properties resveratrol, target prediction analysis, discussed interacting pathways using pharmacology method. Main PK were...
Akkermansia muciniphila (A. muciniphila) is a mucin-degrading bacterium that resides in the mucus layer, but its potential intestinal inflammatory diseases has sparked controversy. It well known both consumption of fructose-containing beverages and psychological stress increase risk disease. Our results revealed high-fructose diet aggravated damage to jejunal mucosal barrier caused by restraint stress, reduced tight junction protein expression digestion absorption capacity, disrupted ability...
The progression of chronic colitis is accompanied by an increase in inflammation and intestinal angiogenesis. Kaempferol, a dietary flavonoid, has been shown to exhibit anti-inflammatory anti-angiogenic properties. However, the effect kaempferol not elucidated. present study aimed investigate effects on angiogenesis microflora mice with colitis. dextran sulfate sodium (DSS)-induced mouse model was used this study. 5-aminosalicylic acid (5-ASA) were evaluated histopathology, ELISA, western...
Glioblastoma is the most common and aggressive brain tumor associated with a poor prognosis. Plant homeodomain finger protein 20 (PHF20) highly expressed in primary human gliomas its expression grade. However, molecular mechanism by which PHF20 regulates glioblastoma remains poorly understood. Genome wide gene analysis was performed to identify differentially genes (DEGs) U87 cells knockdown. Gene ontology (GO) pathway enrichment analyses were investigate functions pathways of DEGs....
Abstract Objectives The purpose of this study was to assess the gastroprotective properties alpha-boswellic acid (α-BA), a pentacyclic triterpene compound from extracts Frankincense. Methods gastroprotection α-BA assessed with ethanol-induced gastric lesions model, by histopathological assessment and measuring juice acidity (pH), wall mucus (GWM), prostaglandins E2 (PGE-2), membrane lipids peroxidation (MDA), superoxide dismutase (SOD) activity, catalase (CAT) activity amount nitric oxide...
The nuclear factor erythroid-2-related 2 (Nrf2) pathway has been considered as a potential target for neuroprotection in stroke. aim of present study was to determine whether corilagin, novel Nrf2 activator, can protect against ischemia-reperfusion injury and explore the underlying mechanism involved. In vivo, rats exposed middle cerebral artery occlusion were applied establish an ischemic stroke model. Posttreatment corilagin significantly reduced infarct volumes apoptotic cells well...
Abstract Acetyl‐11‐keto‐β‐boswellic acid (AKBA), an active triterpenoid compound from the extract of Boswellia serrate, has been reported previously in our group to alleviate fibrosis vascular remodelling. This study aimed elucidate vivo and vitro efficacy mechanism AKBA renal interstitial fibrosis. The experimental was produced C57BL/6 mice via unilateral ureteral obstruction (UUO). Hypoxia‐induced HK‐2 cells were used imitate pathological process vitro. Results showed that treatment...
Importance In several randomized clinical trials, endovascular thrombectomy led to better functional outcomes than conventional treatment at 90 days poststroke in patients with acute basilar artery occlusion. However, the long-term of these have not been well delineated. Objective To evaluate 1-year occlusion following vs control. Design, Setting, and Participants This study is an extension ATTENTION trial, a multicenter, trial. Patients were included between February 2021 January 2022,...