A5054636731- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Pharmacological Effects of Medicinal Plants
- Angiogenesis and VEGF in Cancer
- Synthesis of Organic Compounds
- CO2 Reduction Techniques and Catalysts
- Crystallization and Solubility Studies
- Diabetes Treatment and Management
- Electrocatalysts for Energy Conversion
- Carbohydrate Chemistry and Synthesis
- Virus-based gene therapy research
- Bone Metabolism and Diseases
- Cancer therapeutics and mechanisms
- Click Chemistry and Applications
- Synthetic Organic Chemistry Methods
- Antiplatelet Therapy and Cardiovascular Diseases
- Piperaceae Chemical and Biological Studies
- Apelin-related biomedical research
- SARS-CoV-2 and COVID-19 Research
- X-ray Diffraction in Crystallography
- Advanced battery technologies research
- Renal Diseases and Glomerulopathies
- Autophagy in Disease and Therapy
- Selenium in Biological Systems
- Ginger and Zingiberaceae research
Second Affiliated Hospital of Zhejiang University
2021-2025
Putian University
2025
Zhejiang University
2016-2024
Microbiology Institute of Shaanxi
2023
General Hospital of Shenyang Military Region
2016-2018
Air Force Medical University
2015-2016
Xijing Hospital
2015-2016
Renmin University of China
2016
Nanjing Medical University
2015
Jinan University
2014
Abstract Developing highly efficient carbon aerogels (CA) electrocatalysts based on transition metal‐nitrogen sites is critical for the CO 2 electroreduction reaction (CO RR). However, simultaneously achieving a high current density and Faradaic efficiency (FE) still remains big challenge. Herein, series of unique 3D hierarchical cross‐linked nanostructured CA with (MN, M = Ni, Fe, Co, Mn, Cu) developed RR. An optimal CA/N‐Ni aerogel, featured porous structure exposed M‐N sites, exhibits an...
Functional loss of endothelial cells will lead to development and progression atherosclerosis in diabetic patients. However, dysfunction diabetes has yet be fully understood. We aimed characterize the potential effects liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, on preventing high glucose-induced excessive mitophagic response. Pretreatment with liraglutide prevented downregulation eNOS phosphorylation NO secretion, reduced apoptosis oxidative stress human umbilical vein...
A series of novel 2-pyridone derivatives were synthesized and evaluated for their antihepatitis B virus (HBV) activity cytotoxicity in vitro. Moderate to good against HBV DNA replication was observed these analogues. The most active compounds 5d 6l, with inhibitory (IC(50) = 0.206 0.12 microM, respectively) remarkable high selectivity (selectivity indexes >532 467, respectively). pharmacophore model the proposed by GASP program. consists three hydrophobic points, four HBA one HBD point....
PCV2 encodes protein ORF3, a putative with proapoptotic activity. Our early studies showed that infection triggers ER stress via selective activation of the PERK pathway, branch pathways, in permissive cells for enhanced replication and increased cytosolic Ca 2+ ROS levels. Here we clearly show or Cap expression induces ORF3-independent apoptosis mitochondrial levels cellular as result pathway.
To investigate the drug resistant gene profiles and molecular typing of Acinetobacter baumannii isolates collected from clinical specimens in a comprehensive hospital, Jiangsu province. This study included 120 patients hospital with drug-resistant A. infections on October 2011 to December 2013. Antibiotic susceptibility test was determined by Vitek 2 Compact system. OXA-51, OXA-23, OXA-24, OXA-58, VIM, IMP, SHV, GES, TEM, AmpC, qacEΔ1-sul1, intI l, CarO, aac(6′)-Ib, aac(6′)-II were analyzed...
Oxidative stress plays an important role in the initiation and development of myocardial injury (MI). The peroxisome proliferator-activated receptor gamma coactivator-1α (PGC‑1α)/nuclear factor erythroid 2-related 2 (Nrf2) pathway is considered to be a potential target for cardioprotection MI. Acetyl-11-keto-β-boswellic acid (AKBA) major organic component extracted from Boswellia serrata Roxb. ex Colebr. Hydroxysafflor yellow A (HSYA) principal active constituent Carthamus tinctorius L. In...
ELABELA (ELA), a recently discovered peptide, is highly expressed in adult kidneys and the endothelium system. It has been identified as novel endogenous ligand for apelin receptor (APJ). This study aims to investigate role of ELA diabetic glomerular endothelial pyroptosis its underlying mechanism. Initially, significant decrease mRNA levels was observed renal cortex db/db mice high glucose-treated cells (GECs). also found that deficiency ELA+/- significantly accelerated injury, shown by...
Abstract Objectives The purpose of this study was to assess the gastroprotective properties alpha-boswellic acid (α-BA), a pentacyclic triterpene compound from extracts Frankincense. Methods gastroprotection α-BA assessed with ethanol-induced gastric lesions model, by histopathological assessment and measuring juice acidity (pH), wall mucus (GWM), prostaglandins E2 (PGE-2), membrane lipids peroxidation (MDA), superoxide dismutase (SOD) activity, catalase (CAT) activity amount nitric oxide...
Porcine circovirus type 2 (PCV2) is a small DNA virus that depends heavily on host cells for its infection. This study reports the close relationship between subcellular localization of high-mobility-group box 1 (HMGB1) protein and viral replication during PCV2 Restriction by nuclear HMGB1 early step defense at host-pathogen interface. then upregulates reactive oxygen species (ROS) to prevent sequestration genome expelling into cytosol. It will be interesting if similar evasion strategy...
Mitochondrial dynamics is essential for the maintenance of cell homeostasis. Previous studies have shown that porcine circovirus 2 (PCV2) infection decreases mitochondrial membrane potential and causes elevation reactive oxygen species (ROS), which may ultimately lead to apoptosis. However, whether PCV2 induce mitophagy remains unknown. Here we show PCV2-induced in PK-15 cells via Drp1 phosphorylation PINK1/Parkin activation. enhanced its subsequent translocation mitochondria. could be...
Colorectal cancer (CRC) is a leading cause of mortality while diabetes recognized risk factor for CRC. Here we report that tirzepatide (TZP), novel polypeptide/glucagon-like peptide 1 receptor (GIPR/GLP-1R) agonist the treatment diabetes, has role in attenuating CRC growth. TZP significantly inhibited colon cell proliferation promoted apoptosis vitro and induced durable tumor regression vivo under hyperglycemic nonhyperglycemic conditions across multiple murine models. As glucose metabolism...
Vascular remodeling is an important complication of hypertension with oxidative stress-related profibrotic pathways involved. The transforming growth factor β1 (TGF-β1) has been shown to be a potential target vasoprotection, and multiple roles in vascular remodeling. Acetyl-11-Keto-β-Boswellic Acid (AKBA) one the active principles Boswellic acids, shows antioxidant activity many diseases. study determine effects AKBA on systemic stress In experiments, spontaneously hypertensive rats (SHR)...
Considering the fact that clinical porcine circovirus-associated diseases (PCVAD) mostly results from activation of latent PCV2 infection by confounding factors such as coinfection or environmental stresses, we propose might impose oxidative stress to animals, where in infected cells utilize elevated reactive oxygen species (ROS) promote HMGB1 migration out nuclei favor its replication. An animal model with a particular stressor could be approached without antioxidant treatment examine...
Background: Low grade of sterile inflammation plays detrimental roles in the progression diabetic kidney disease (DKD). Sappanone A (SA), a kind homoisoflavanone isolated from heartwood Caesalpinia sappan, exerts anti-inflammatory effects acute injury. However, whether SA has beneficial on remains further exploration. Methods and Results: In present study, uninephrectomized male mice were treated with Streptozotocin (STZ, 50 mg/kg) for five consecutive days to induce diabetes. Next,...
Vascular remodeling is a common complication and pathological basis of hypertension. Transforming growth factor‑β1 (TGF‑β1)/small mothers against decapentaplegic 3 (Smad3) considered potential therapeutic target for vascular in The present study aimed to demonstrate the antifibrotic effects telmisartan examined mechanisms associated with its prevention remodeling. Spontaneously hypertensive rats (SHRs) were treated (20 mg/kg), contractility, reactivity oxidative stress preliminarily...
BACKGROUND: Restoring the capacity of endothelial progenitor cells (EPCs) to promote angiogenesis is major therapeutic strategy diabetic peripheral artery disease. The aim this study was investigate effects GLP-1 (glucagon-like peptide 1; 32–36)—an end product GLP-1—on EPCs and T1DM (type 1 diabetes) mice, as well its interaction with classical GLP-1R (GLP-1 receptor) pathway effect on mitochondrial metabolism. METHODS: In in vivo experiments, we conducted streptozocin-induced type mice a...