A5009894408- Natural product bioactivities and synthesis
- Cancer Mechanisms and Therapy
- Seaweed-derived Bioactive Compounds
- Phytochemistry and Biological Activities
- Immunotherapy and Immune Responses
- Protein Hydrolysis and Bioactive Peptides
- Asymmetric Hydrogenation and Catalysis
- Cytokine Signaling Pathways and Interactions
- Food composition and properties
- Cancer Immunotherapy and Biomarkers
- Crystallization and Solubility Studies
- Medicinal plant effects and applications
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Polysaccharides and Plant Cell Walls
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Biochemical and Molecular Research
- Insect Utilization and Effects
- Immune cells in cancer
- Aquaculture Nutrition and Growth
- Peptidase Inhibition and Analysis
- Proteins in Food Systems
- Asymmetric Synthesis and Catalysis
Southern Medical University
2015-2025
Shanghai University
2024-2025
Shanghai Sixth People's Hospital
2017-2025
Shanghai University of Medicine and Health Sciences
2017-2025
Shanghai Jiao Tong University
2017-2025
Xian Central Hospital
2011-2024
Anhui University of Science and Technology
2020-2024
Nanjing Medical University
2024
Huaian First People’s Hospital
2024
East China Normal University
2016-2024
The chemical composition, anti-inflammatory, cytotoxic and antioxidant activities of essential oil from leaves Mentha piperita (MEO) grown in China were investigated. Using GC-MS analysis, the composition MEO was characterized, showing that it mainly composed menthol, menthone menthy acetate. exhibited potent anti-inflammatory a croton oil-induced mouse ear edema model. It could also effectively inhibit nitric oxide (NO) prostaglandin E2 (PGE2) production lipopolysaccharide (LPS)-activated...
Research Article10 March 2016Open Access Source DataTransparent process CRISPR/Cas9-mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse Yuting Guan Shanghai Key Laboratory Regulatory Biology, Institute Biomedical Sciences and School Life Sciences, East China Normal University, Shanghai, Search for more papers by this author Yanlin Ma Corresponding Author Hainan Provincial Human Reproductive Medicine Genetic Research, Medical Center, the...
Abstract: Colorectal cancer (CRC) is a common digestive malignancy and emerging studies have closely linked its initiation development with gut microbiota changes. Fusobacterium nucleatum ( Fn ) has been recently identified as pathogenic bacteria for CRC; however, prognostic significance patients poorly investigated less within late stage. Therefore, in this study, we made efforts to analyze level retrospective cohort of 280 stage III/IV CRC patients. We found that the was abnormally high...
Signal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic target. Unfortunately, targeting STAT3 with small molecules has proven to be very challenging, for full activation STAT3, the cooperative phosphorylation both tyrosine 705 (Tyr705) serine 727 (Ser727) needed. Further, a selective inhibitor dual not been developed. Here, we identified low nanomolar potency highly small-molecule that simultaneously inhibits Tyr705 Ser727 phosphorylation. YY002...
A facile synthesis of copper nanoparticles supported on an ordered mesoporous polymer was developed for solvent-free Sonogashira coupling reactions.
Breast cancer is one of the most lethal cancers in women when it reaches metastatic stage. Here, we screen a library small molecules for inhibitors breast cell invasion, and use structure/activity relationship studies to develop series with improved activity. We find WJ460 as lead compounds exerting anti-metastatic activity nanomolar range cells. Proteomic biochemical identify myoferlin (MYOF) direct target WJ460. In parallel, loss MYOF or pharmacological inhibition by reduces extravasation...
Immunotherapies targeting immune checkpoint molecules have shown promising treatment for a subset of cancers; however, many "cold" tumors, such as prostate cancer, remain unresponsive. We aimed to identify potential targetable marker relevant cancer and develop novel immunotherapy.Analysis transcriptomic profiles at single-cell resolution was performed in clinical patients' samples, along with integrated analysis multiple RNA-sequencing datasets. The antitumor activity YY001, EP4 antagonist,...
Abstract Purpose: Pancreatic cancer is the worst prognosis among all human cancers, and novel effective treatments are urgently needed. Signal transducer activator of transcription 3 (STAT3) has been demonstrated as a promising target for pancreatic cancer. Meanwhile, selectively targeted STAT3 with small molecule remains challenging. Experimental Design: To specifically identify inhibitors, more than 1.3 million compounds were screened by structure-based virtual screening confirmed direct...
In this research, oat resistant starch (ORS) was prepared by autoclaving-retrogradation cycle (ORS-A), enzymatic hydrolysis (ORS-B), and ultrasound combined (ORS-C). Differences in their structural features, physicochemical properties digestive were studied. Results of particle size distribution, XRD, DSC, FTIR, SEM vitro digestion showed that ORS-C a B + C-crystal, had larger size, the smallest span value, highest relative crystallinity, most ordered stable double helix structure, roughest...
A cascade [3 + 2] annulation and ring opening of N-aryloxyacetamides with 1-alkynylcyclobutanols via Rh(III)-catalyzed redox-neutral C–H/C–C activations using internal oxidative O–NHAc −OH as the dual directing groups has been achieved. This reaction provided an efficient regioselective approach to benzofuran derivatives good functional group compatibility high yields.
Abstract Rapid metabolism differentiates cancer cells from normal and relies on anaplerotic pathways. However, the mechanisms of anaplerosis‐associated enzymes are rarely understood. The lack potent selective antimetabolism drugs restrains further clinical investigations. A small molecule ZY‐444 (( N 4 ‐((5‐(4‐(benzyloxy)phenyl)‐2‐thiophenyl)methyl)‐ 2 ‐isobutyl‐2,4‐pyrimidinediamine) is discovered to inhibit cell proliferation specifically, having efficacies against tumor growth,...
Abstract The work reported within this paper describes an example of the application bimetallic catalysts system in allylic substitution reactions. development new nucleophiles and control enantio‐ diastereoselectivity are main research topics area. An improvement reactivity has been realized for dual Ir/Cu catalyzed alkylation inactive prochiral nucleophiles, under mild reaction conditions. Furthermore, choice metallacyclic iridium complex chiral Cu‐Phox combination allows access to all...
MEK is a canonical effector of mutant KRAS; however, inhibitors fail to yield satisfactory clinical outcomes in KRAS-mutant cancers. Here, we identified mitochondrial oxidative phosphorylation (OXPHOS) induction as profound metabolic alteration confer non-small cell lung cancer (NSCLC) resistance the inhibitor trametinib. Metabolic flux analysis demonstrated that pyruvate metabolism and fatty acid oxidation were markedly enhanced coordinately powered OXPHOS system resistant cells after...
Matrix metalloproteinases (MMPs), mostly abundant in the tumor extracellular matrix (ECM), cells, and vasculatures, are closely correlated with progression metastasis. In this case, making use of MMPs was supposed to achieve site-specific drug delivery a satisfactory treatment effect. Herein, we rationally developed novel microenvironment cell dual-targeting nanoparticle by integrating chemotherapeutic-loaded drug-loaded carrier versatile polypeptide-LinTT1-PVGLIG-TAT (LPT) which is composed...
This study describes the extraction, preliminary characterization and evaluation of in vitro antitumor antioxidant activities polysaccharides extracted from Mentha piperita (MPP). The optimal parameters for extraction MPP were obtained by Box-Behnken experimental design response surface methodology (RSM) at ratio water to raw material 20, time 1.5 h temperature 80 °C. Chemical composition analysis showed that was mainly composed glucuronic acid, galacturonic glucose, galactose arabinose,...
The fucoidans were obtained by extraction with water and gradient precipitation different concentrations of ethanol. main structural characterisations bioactivities achieved. Four fractions water-soluble crude molecular weights - SPC60, SPC70, SPH60, SPH70 extracted from S. pallidum collected the Yellow Sea, China, using cold hot extraction, fractional Chemical analysis demonstrated that all these fucoidan consisted fucose, rhamnose, xylose, mannose, glucose, galactose monosaccharide mole...