A5036274384- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Research and Splicing
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- MRI in cancer diagnosis
- Inflammatory Biomarkers in Disease Prognosis
- Liver Disease Diagnosis and Treatment
- Pelvic floor disorders treatments
- Metabolism, Diabetes, and Cancer
- Wnt/β-catenin signaling in development and cancer
- Pancreatic function and diabetes
- Radiomics and Machine Learning in Medical Imaging
- Medicinal plant effects and applications
- Beetle Biology and Toxicology Studies
- Urological Disorders and Treatments
- Advanced MRI Techniques and Applications
- Signaling Pathways in Disease
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Microfluidic and Capillary Electrophoresis Applications
- Genetics, Aging, and Longevity in Model Organisms
- Biological Activity of Diterpenoids and Biflavonoids
- Biosensors and Analytical Detection
University of Science and Technology of China
2012-2025
Hefei Infectious Disease Hospital
2022-2025
Peking University People's Hospital
2013-2024
Peking University
2013-2024
National Clinical Research Center for Digestive Diseases
2023-2024
Capital Medical University
2023-2024
Beijing Friendship Hospital
2023-2024
Kunming Medical University
2015-2024
Beijing Tongren Hospital
2024
Beijing Chest Hospital
2024
Abstract Background Immune system evasion, distance tumor metastases, and increased cell proliferation are the main reasons for progression of non-small lung cancer (NSCLC) death NSCLC patients. Dysregulation circular RNAs plays a critical role in NSCLC; therefore, further understanding biological mechanisms abnormally expressed circRNAs is to discovering novel, promising therapeutic targets treatment. Methods The expression RNA fibroblast growth factor receptor 1 (circFGFR1) tissues, paired...
Dysregulation of long noncoding RNAs (lncRNAs) plays important roles in carcinogenesis and tumor progression, including hepatocellular carcinoma (HCC). Small nucleolar RNA host gene 3 (SNHG3) has been considered as an lncRNA to be associated with a poor prognosis patients HCC. Here, we reported that SNHG3 expression was significantly higher the highly metastatic HCC (HCCLM3) cells compared lowly (Hep3B PLC/PRF/5). Furthermore, forced promoted cell invasion, epithelial‐mesenchymal transition...
Food and other environmental factors affect gene expression behaviour of animals. Differences in bacterial food the longevity Caenorhabditis elegans. However, no research has been carried out to investigate whether bacteria could utilize endogenous RNAs C. elegans physiology. Here we show that two Escherichia coli noncoding RNAs, OxyS DsrA, impact on physiology downregulates che-2, leading impairment chemosensory DsrA suppresses diacylglycerol lipase F42G9.6, a decrease longevity. We also...
Growing evidence suggests that YAP/TAZ are mediators of the Hippo pathway and promote breast cancer. However, roles transcription factor partners TEADs in cancer remain unclear. Here we found TEAD4 was expressed cell lines, especially triple negative cancers (TNBC) lines. binds to KLF5. Knockdown either or KLF5 HCC1937 HCC1806 cells induced expression CDK inhibitor p27. Depletion activated p27 gene promoter increased mRNA levels. partially prevents growth inhibition caused by knockdown....
MicroRNA128-1 (miR128-1), as a brain-specific miRNA, is downregulated in glioblastoma multiforme (GBM) and closely associated with the progression of GBM. However, underlying molecular mechanism downregulation its role regulation tumorigenesis anticancer drug resistance GBM remains largely unknown. In current study,we found that miR128-1 was glioma stem-like cells (GSCs). Intriguingly, treatment DNA methylation inhibitors 5-Aza-CdR (Aza) 4-phenylbutyric acid (PBA) resulted upregulation both...
Breast cancer is one of the most lethal cancers in women when it reaches metastatic stage. Here, we screen a library small molecules for inhibitors breast cell invasion, and use structure/activity relationship studies to develop series with improved activity. We find WJ460 as lead compounds exerting anti-metastatic activity nanomolar range cells. Proteomic biochemical identify myoferlin (MYOF) direct target WJ460. In parallel, loss MYOF or pharmacological inhibition by reduces extravasation...
Previous studies suggested that zinc level was related to a certain diabetic microvascular complication. However, the relationship between and all complications in type 2 patients remains unknown. The purpose of this study analyze each complication identify features low serum level.We included hospitalized with diabetes (T2D) at our department from May 30, 2013 March 31, 2014. We initially compared levels specific those without. then analyzed association Furthermore, we identified unique...
Long noncoding RNAs (lncRNAs) have been implicated in numerous physiological and pathological processes, including cancer development progression. However, the role molecular mechanism of lncRNAs resistance to chemotherapy colorectal (CRC) remain enigmatic. Here, we found that lncRNA small Cajal body-specific RNA 2 (SCARNA2) is expressed higher CRC tissues than adjacent normal tissues, a robust expression SCARNA2 correlated with bad prognosis patients after surgery. overexpression...
Recently, an increasing number of studies have reported that dysregulation long noncoding RNAs (lncRNAs) plays important role in cancer initiation and progression, including epithelial ovarian carcinoma (EOC). However, little is known about the detailed biological functions lncRNA small nucleolar RNA host gene 22 (SNHG22) during progression EOC. Here, we found SNHG22 was significantly increased EOC tissues associated with a low level differentiation. Forced expression promoted chemotherapy...
Abstract Background To examine the cardiovascular disease (CVD) risks associated with metabolic dysfunction‐associated steatotic liver (MASLD) and different numbers of cardiometabolic risk factors (CMRFs) in patients inflammatory bowel (IBD) based on a long‐term prospective cohort. Methods Prevalent IBD at baseline who were free CVD, cancer, alcoholic disease, cancer hepatitis B/C virus seropositive included (N = 4204). MASLD, MASLD subtypes [pure increased alcohol intake (MetALD)],...
Purpose To investigate the predictive value of serum hepatitis B virus (HBV) RNA on HBeAg seroconversion in treated chronic (CHB) patients. Methods Sixty-four HBeAg-positive CHB patients were selected. They divided into group including 11 cases and non-seroconversion 53 cases. HBV levels other laboratory results measured at baseline week 12, 24, 48, 72 during treatment both groups. The level for was analyzed. Results Significant differences existed DNA between two groups while there no...
Emerging studies show that long noncoding RNAs (lncRNAs) have important roles in carcinogenesis. This study investigated the role of lncRNA highly upregulated liver cancer (HULC) expression glioma and its clinical significance patients.HULC was detected tissues cell lines by using real-time quantitative reverse transcription polymerase chain reactions. Association between HULC levels clinicopathological factors patients prognosis also analyzed. Expression restored knocked down line U87 cDNA...
Cantharidin, one of the active components mylabris, is believed to have antitumor activity. Cantharidin selectively inhibits protein phosphatase 2A (PP2A), which can repress multiple oncogenic kinases (ERK, JNK, PKC, and NF-κB). Researches in vitro shown that cantharidin suppresses cell viability metastasis pancreatic cancer cells. This study aims investigate effects on xenografts vivo. Xenograft models were established using cells stably expressing luciferase. growth was evaluated by living...
Prostate cancer is the most common among men in Unites States. The cytokine IL-6 activates several prostate pathways, but its upstream trans-signaling pathway remains poorly understood. In this study, we evaluated role of PDCD4 gene expression and how microRNA miR-21 regulates process cell lines PC-3 LNCaP. pattern from samples human cancer, precancerous lesions, benign prostatic hyperplasia was investigated by immunohistochemistry. transcription translation were detected quantitative...
Colorectal cancer (CRC) represents the third most common malignancy worldwide. The aim of present study was to investigate predictive values platelet-associated indicators, including platelet count (PLT), plateletcrit (PCT), mean volume (MPV) and distribution width (PDW) in patients with resectable CRC. current retrospective included 153 who were pathologically diagnosed divided into two groups according median value PLT, PCT, MPV or PDW. To evaluate changes PDW following resection adjuvant...