A5102768898- Angiogenesis and VEGF in Cancer
- Diabetes Treatment and Management
- Pancreatic and Hepatic Oncology Research
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Liver physiology and pathology
- Cardiovascular Issues in Pregnancy
- S100 Proteins and Annexins
- PI3K/AKT/mTOR signaling in cancer
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Reproductive System and Pregnancy
- Antiplatelet Therapy and Cardiovascular Diseases
- Protease and Inhibitor Mechanisms
- Kruppel-like factors research
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy-related medical research
- Apelin-related biomedical research
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
Second Affiliated Hospital of Zhejiang University
2023-2025
Zhejiang University
2024
Lanzhou University
2021
State Key Laboratory of Genetic Engineering
2011
Fudan University
2011
Shanghai First People's Hospital
2011
Colorectal cancer (CRC) is a leading cause of mortality while diabetes recognized risk factor for CRC. Here we report that tirzepatide (TZP), novel polypeptide/glucagon-like peptide 1 receptor (GIPR/GLP-1R) agonist the treatment diabetes, has role in attenuating CRC growth. TZP significantly inhibited colon cell proliferation promoted apoptosis vitro and induced durable tumor regression vivo under hyperglycemic nonhyperglycemic conditions across multiple murine models. As glucose metabolism...
BACKGROUND: Restoring the capacity of endothelial progenitor cells (EPCs) to promote angiogenesis is major therapeutic strategy diabetic peripheral artery disease. The aim this study was investigate effects GLP-1 (glucagon-like peptide 1; 32–36)—an end product GLP-1—on EPCs and T1DM (type 1 diabetes) mice, as well its interaction with classical GLP-1R (GLP-1 receptor) pathway effect on mitochondrial metabolism. METHODS: In in vivo experiments, we conducted streptozocin-induced type mice a...
Abstract Objective. To investigate expression of matrix metalloproteinases (MMPs) and the tissue inhibitors MMPs (TIMPs) at feto‐maternal interface non‐implantation sites in unruptured tubal pregnancies. Design. Prospective study. Setting. University teaching hospital. Population. Eighteen patients with pregnancy undergoing salpingectomy. Methods. Immunohistochemistry was used to detect MMP‐2, ‐9 ‐14, TIMP‐1, ‐2 ‐3 regions Fallopian tube. Serum levels human chorionic gonadotropin (β‐hCG)...
Abstract Glucagon-like peptide 1 (GLP-1) improves angiogenesis, but the mechanism remains unclear. To address this question, we conducted a metabolomics analysis in bone marrow-derived endothelial progenitor cells (EPCs) isolated from T1DM mice treated with or without GLP-1(32-36) amide, an end-product of GLP-1. treatment recovered glycolysis. In addition, rescued diabetic ischemic lower limbs and EPCs dysfunction by regulating PFKFB3-driven glycolytic flux capacity mitochondrial dynamics....
Abstract Background: PCGF4 is highly expressed in liver cancer and can be used as a marker for stem cells. However, PCGF2, homologue of PCGF4, not clear whether it HCC, regulates the stemness Methods: IHC Western blot were to detect expression PCGF2 protein human HCC tissues cell lines. Flow cytometry sphere formation performed effect or on stem-like properties Kaplan-Meier curves conducted OS DFS. Cell viability was measured at indicated time points using Counting Kit-8. We KEGG analysis...