A5100375714- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Luminescence and Fluorescent Materials
- Sulfur Compounds in Biology
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Click Chemistry and Applications
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Chemical Synthesis and Analysis
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Thermography and Photoacoustic Techniques
- Luminescence Properties of Advanced Materials
- Optical Imaging and Spectroscopy Techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Metal-Organic Frameworks: Synthesis and Applications
- Extracellular vesicles in disease
- Advanced Chemical Sensor Technologies
- Biosensors and Analytical Detection
- Carbon and Quantum Dots Applications
- Dendrimers and Hyperbranched Polymers
- Porphyrin and Phthalocyanine Chemistry
South China Normal University
2016-2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
Shaanxi University of Science and Technology
2025
Chungnam National University
2025
Central South University
2025
Nanjing University
2021-2025
Nanjing General Hospital of Nanjing Military Command
2025
Shandong University
2014-2024
Sun Yat-sen University
2021-2024
Immunotherapeutic interventions represent a promising approach to treating cancer, with strategies such as immune checkpoint blockade (ICB), immunogenic sonodynamic therapy (SDT), and adjuvant T cell delivery having exhibited clinical promise. In this report, we describe the use of cancer membrane-coated triphenylphosphonium (TPP) decorated nano-metal-organic framework (nMOF) constructs [Zr-TCPP(TPP)/R837@M] that were used generate homologous, mitochondria-targeted platforms high rate...
Phototheranostics based on upconversion nanoparticles (UCNPs) offer the integration of imaging diagnostics and phototherapeutics. However, programmable control photoactivation therapy with minimum side effects is challenging due to lack ideal switchable UCNPs agents. Here we demonstrate a facile strategy switch near infrared emission at 800 nm from rationally designed by modulating irradiation laser into pulse output. We further synthesize theranostic nanoagent combining photosensitizer...
Abstract Compared with traditional piezoelectric ultrasonic devices, optoacoustic devices have unique advantages such as a simple preparation process, anti-electromagnetic interference, and wireless long-distance power supply. However, current remain limited due to low damage threshold energy conversion efficiency, which seriously hinder their widespread applications. In this study, using self-healing polydimethylsiloxane (PDMS, Fe-Hpdca-PDMS) carbon nanotube composite, flexible patch is...
Developing multifunctional phototheranostics with nanoplatforms offers promising potential for effective eradication of malignant solid tumors. In this study, we develop a phototheranostic by combining photothermal therapy (PTT) and photoacoustic (PAT) based on tumor-targeting nanoagent (DBCO-ZnPc-LP). The DBCO-ZnPc-LP was facilely prepared self-assembling single lipophilic near-infrared (NIR) dye zinc(II)-phthalocyanine (ZnPc) lipid-poly(ethylene glycol) (LP) following modified further...
We have developed a new ratiometric fluorescent probe composed of coumarin-merocyanine dyad based on the FRET mechanism. The showed clear dual-emission signal changes in blue and red spectral windows upon addition H2S dose dependent manner under single wavelength excitation. targeted mitochondria with high selectivity sensitivity toward H2S.
A water-soluble porphyrinato ytterbium complex linked with rhodamine B (Yb-2) showed mitochondria-specific subcellular localization and strong two-photon-induced NIR emissions (λ(em) = 650 nm, porphyrinate ligand π → π* transition; λ(em) 1060 Yb(III) (5)F(5/2) (5)F(7/2) transitions; σ(2) 375 GM in DMSO) an impressive emission quantum yield (1% at λ(ex) 340 nm; 2.5% 430 nm) aqueous solution.
Near-infrared (NIR)-absorbing organic nanoparticles (ONPs) are emerging candidates for "one-for-all" theranostic nanomaterials with considerations of safety and formulation in mind. However, facile fabrication methods improvements the photothermal conversion efficiency (PCE) photostability likely needed before a clinically viable set emerges. Herein, new compound, [porphyrin-diketopyrrolopyrrole (Por-DPP)] donor-acceptor structure was synthesized, where porphyrin used as donor unit while...
Here, we report a reversible photoacoustic (PA) probe, BDP-DOH, to image the localized redox state in vivo via monitoring dynamic changes of couple, superoxide anion (O2•–) and glutathione (GSH). The probe features significant shift absorption between 680 750 nm during selective oxidation with O2•– reductive recovery GSH, thus showing responsiveness intensity ratio (PA750/PA680) successfully visualize status tissue situ. This specific sensitive response provides potential technical tool...
Triple-negative breast cancer (TNBC) is an aggressive subset of and currently lacks effective therapeutic targets. As two main phototherapeutic methods, photothermal therapy (PTT) photodynamic (PDT) show many advantages in TNBC treatment, their combination with chemotherapy can achieve synergistic effects. In the present study, a biomimetic nanoplatform was developed based on leukocyte/platelet hybrid membrane (LPHM) dendritic large pore mesoporous silicon nanoparticles (DLMSNs). A near...
Abstract Sonodynamic therapy (SDT), which uses reactive oxygen species to target tumors, has shown promise in the management of unresectable cancers. However, hypoxic tumor environment limits SDT efficiency, making complete destruction challenging. Here, a dual‐sonosensitizer nanoplatform is developed by loading an alkyl radical generator (2,2‐azobis[2‐(2‐imidazolin‐2‐yl)propane] dihydrochloride, AIPH) onto zirconium metal–organic framework (Zr‐MOF). The Zr‐MOF@AIPH nanoparticles (NPs) can...
Chromophores that absorb in the tissue-penetrant far-red/near-infrared window have long served as photocatalysts to generate singlet oxygen for photodynamic therapy. However, cytotoxicity and side reactions associated with sensitization posed a problem using long-wavelength photocatalysis initiate other types of chemical biological environments. Herein, silicon-Rhodamine compounds (SiRs) are described inducing rapid bioorthogonal chemistry 660 nm light through oxidation dihydrotetrazine...
Ultrasound super-resolution imaging through localisation and tracking of microbubbles can achieve sub-wave-diffraction resolution in mapping both micro-vascular structure flow dynamics deep tissue <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in vivo</i> . Currently, it is still challenging to high accuracy particularly with limited frame rates the presence bubble concentrations. This study introduces microbubble image features into a...
With the widespread interest and uptake of super-resolution ultrasound (SRUS) through localization tracking microbubbles, also known as microscopy (ULM), many algorithms have been developed. ULM can image centimeters into tissue in-vivo track microvascular flow non-invasively with sub-diffraction resolution. In a significant community effort, we organized challenge, Ultrasound Localization TRacking Algorithms for Super-Resolution (ULTRA-SR). The aims this paper are threefold: to describe...
Significance Next-generation photodynamic therapy (NG-PDT) for the treatment of tumors preponderates over conventional practices in that it is a kind effective precision medicine with minimal invasive procedures and side effects. Herein, newly developed NG-PDT paradigm agent gadolinium-porphyrin complex, Gd-N, introduced, which can successfully trace recognize tumor tissues via simple injection into blood vessel mouse models, selectively accumulate within them, superiorly exert therapeutic...
Remote optical detection and imaging of specific tumor-related biomarkers simultaneous activation therapy according to the expression level in tumor site with theranostic probes should be an effective modality for treatment cancers. Herein, upconversion nanobeacon (UCNPs-MB/Dox) is proposed as a new nanoprobe ratiometrically detect visualize thymidine kinase 1 (TK1) mRNA that can simultaneously trigger Dox release activate chemotherapy accordingly. UCNPs-MB/Dox constructed conjugation TK1...