A5027358989- Protist diversity and phylogeny
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
- Plant Reproductive Biology
- Nanoplatforms for cancer theranostics
- Insect and Arachnid Ecology and Behavior
- Plant Molecular Biology Research
- Advanced Polymer Synthesis and Characterization
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Photosynthetic Processes and Mechanisms
- Chronic Lymphocytic Leukemia Research
- Traditional Chinese Medicine Analysis
- Epigenetics and DNA Methylation
- Plant and animal studies
- Supramolecular Self-Assembly in Materials
- Extracellular vesicles in disease
- Natural product bioactivities and synthesis
- Polymer Surface Interaction Studies
- Bacteriophages and microbial interactions
- Photochromic and Fluorescence Chemistry
- Periodontal Regeneration and Treatments
- Microbial Community Ecology and Physiology
- Chronic Myeloid Leukemia Treatments
- Pharmacological Effects of Natural Compounds
Institute of Hydrobiology
2018-2024
Chinese Academy of Sciences
2018-2024
Université de Lille
2024
University of Chinese Academy of Sciences
2011-2024
Huazhong Agricultural University
2024
State Key Laboratory of Freshwater Ecology and Biotechnology
2020-2024
Ministry of Agriculture and Rural Affairs
2024
Institute of Hydrobiology, Biology Centre, Academy of Sciences of the Czech Republic
2024
Inner Mongolia Agricultural University
2024
Zhejiang University
2021-2023
Summary Bone marrow‐derived mesenchymal stem cells ( BMMSC s) exhibit degenerative changes, including imbalanced differentiation and reduced proliferation during aging, that contribute to age‐related bone loss. We demonstrate here autophagy is significantly in aged s compared with young s. The inhibitor 3‐methyladenine (3‐ MA ) could turn into a relatively state by reducing their osteogenic capacity enhancing adipogenic capacity. Accordingly, the activator rapamycin restore biological...
Abstract Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self-detained system (TCASS) and incorporate imaging probes therapeutics. We show in different mouse models that TCASS accumulates solid tumours. The molecules enhanced accumulation tumour regions via effect recognition induced self-assembly. Analysis molecular penetration tissue shows vivo self-assembly increases capability compared to...
Rationale: The impaired function of endogenous bone marrow mesenchymal stem cells (BMMSCs) is a determinant in the development osteoporosis (OP). Recent researches have proved that autophagy plays an important role maintenance skeletal phenotype. However, whether affects OP through regulating BMMSCs remains elusive. Methods: Ovariectomy (OVX)-induced model and sham were established 8-week-old C57 mice. differentiation immunoregulation properties from two models examined by...
Topological structures of bio-architectonics and bio-interfaces play major roles in maintaining the normal functions organs, tissues, extracellular matrix, cells. In-depth understanding natural self-assembly mechanisms mimicking functional provide us opportunities to artificially control assemblies their biofunctions. Here, we report an intracellular enzyme-catalyzed polymerization approach for efficient synthesis polypeptides situ construction topology-controlled nanostructures. We reveal...
Autophagy plays a crucial role in the metabolic process. So far, conventional methods are incapable of rapid, precise, and real-time monitoring autophagy living objects. Herein, we describe an situ intracellular self-assembly strategy for quantitative temporal determination objectives. The intelligent building blocks (DPBP) composed by bulky dendrimer as carrier, bis(pyrene) derivative (BP) signal molecule, peptide linker responsive unit that can be cleaved autophagy-specific enzyme, i.e.,...
Numerous references made clear that Triphala is revered as a multiuse therapeutic and perhaps even panacea historically. Nevertheless, the protective mechanism of on cardio-cerebral vascular diseases (CCVDs) remains not comprehensive understanding. Hence, network pharmacology-based method was suggested in this study to address problem. This based pharmacology bioinformatics analysis. Information compounds herbal medicines formula acquired from public databases. Oral bioavailability well...
Intracellular construction of nanoaggregates from synthetic molecules to mimic natural ordered superstructures has gained increasing attention recently. Here, we develop an endogenous stimuli-induced aggregation (eSIA) approach construct functional for sensing and monitoring cellular physiological processes in situ. We design a series thermosensitive polymer–peptide conjugates (PPCs), which are capable constructing cells based on their isothermal phase transition property. The PPCs composed...
Resveratrol is a natural polyphenol in lots of foods and traditional Chinese medicines, which has shown promising treatment for neurodegenerative diseases (NDs). However, the molecular mechanisms its action have not been systematically studied yet. In order to elucidate network pharmacological prospective effects resveratrol on NDs, we assessed pharmacokinetics (PK) properties resveratrol, target prediction analysis, discussed interacting pathways using pharmacology method. Main PK were...
We herein report a thermocontrolled strategy for realizing in situ conformational transition of polymer-peptide conjugates at cell surfaces to manipulate and monitor HER2 receptor clustering, which finally result effective breast cancer proliferation inhibition. Functional paring motifs (HBP) are covalently linked synthetic thermoresponsive polymer PNIPAAm incorporate temperature control properties targeting peptide. At 40 °C, the polymers collapse act as "shield" block aggregation HBP. Upon...
A morphospecies is defined as a taxonomic species based wholly on morphology, but often consist of clusters cryptic that can be identified genetically or molecularly. The nature the evolutionary novelty accompanies speciation in an intriguing question. Morphospecies are particularly common among ciliates, group unicellular eukaryotes separates 2 kinds nuclei—the silenced germline nucleus (micronucleus [MIC]) and actively expressed somatic (macronucleus [MAC])—within cytoplasm. Because their...
Buyang Huanwu Decoction (BYHWD) is used to promote blood circulation and widely in Chinese clinical practice for the treatment prevention of ischemic cerebral vascular diseases. However, mechanism active compounds BYHWD treat stroke are not well understood. The current study aimed identify potential components explore its using network pharmacology bioinformatics analyses. were obtained from public databases. Oral bioavailability drug-likeness screened absorption, distribution, metabolism...
Anisotropic structures made by hierarchical self-assembly and crystallization play an essential role in the living system. However, spontaneous formation of liquid crystalline hydrogel low molecular weight organic molecules with controlled properties remains challenging. This work describes a rational design tetrapeptide without N-terminal modification chemical conjugation that utilizes intermolecular interactions to drive nanofiber bundles two-component system, which could not be accessed...
The purpose of this work was to investigate the bioactive compounds, core genes, and pharmacological mechanisms provide a further research orientation Erzhi pill (EZP) on drug-induced liver injury (DILI).At first, we collected information compounds EZP from Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform (TCMSP) previous studies. And then, targets related DILI were obtained 4 public databases. At last, Cytoscape used establish visual network. Moreover, Gene...
Although most species have two sexes, multisexual (or multi-mating type) are also widespread. However, it is unclear how mating-type recognition achieved at the molecular level in species. The unicellular ciliate Tetrahymena thermophila has seven mating types, which determined by MTA and MTB proteins. In this study, we found that both proteins essential for cells to send or receive complete information, transmission of signal requires be expressed same cell. We form a complex localizes...
The transcription factor Sox4 plays an indispensable role in the development of early progenitor B cells from hematopoietic stem cells. However, its B-cell acute lymphoblastic leukemia, a malignant counterpart normal cells, is not fully understood. Here we show that SOX4 highly expressed human leukemia To systematically study function established genetically defined mouse model by transforming carrying floxed allele and inducing deletion self-excising Cre recombinase. This allowed us to work...
Abstract Dental implants are widely used to replace missing teeth, providing patients with unparalleled levels of effectiveness, convenience, and affordability. The biological basis for the clinical success dental is osseointegration. Bone aging a high-risk factor reduced osseointegration survival rates implants. In aged individuals, mesenchymal stem cells (MSCs) in bone marrow show imbalanced differentiation reduction osteogenesis an increase adipogenesis. This leads impaired implant...
To investigate the mechanisms underlying initiation of sexual cell cycle in eukaryotes, we have focused on cyclins and cyclin-dependent kinases (CDKs) well-studied model ciliate, Tetrahymena thermophila We identified two genes, CDK19 CYC9, which are highly co-expressed with mating-associated factors MTA, MTB HAP2. Both CYC9 were found to be essential for mating T. Subcellular localization experiments suggested that these proteins located at oral area, including conjugation junction or...
Evolutionarily conserved E2F family transcription factors regulate the cell cycle via controlling gene expression in a wide range of eukaryotes. We previously demonstrated that meiosis-specific factor E2fl1 had an important role meiosis model ciliate Tetrahymena thermophila. Here, we report another DPL2 correlates highly with E2FL1. Similar to e2fl1Δ cells, dpl2Δ cells undergo meiotic arrest prior anaphase I, five chromosomes adopting abnormal tandem arrangement. Immunofluorescence staining...