A5034960507- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Luminescence and Fluorescent Materials
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Peptidase Inhibition and Analysis
- Enzyme Production and Characterization
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Molecular Sensors and Ion Detection
- Immune cells in cancer
- Dendrimers and Hyperbranched Polymers
- Phagocytosis and Immune Regulation
- RNA modifications and cancer
- Neuroblastoma Research and Treatments
- Epilepsy research and treatment
- Micro and Nano Robotics
- EEG and Brain-Computer Interfaces
- Chemical Synthesis and Analysis
- Nanoparticle-Based Drug Delivery
- Cancer therapeutics and mechanisms
- Cannabis and Cannabinoid Research
- Graphene and Nanomaterials Applications
National Center for Nanoscience and Technology
2013-2024
First People's Hospital of Foshan
2019-2024
University of Chinese Academy of Sciences
2015-2024
Tianma Microelectronics (China)
2023
Chinese Academy of Sciences
2022
Brigham and Women's Hospital
2019-2021
Harvard University
2019-2021
Sun Yat-sen University
2018-2019
Center for NanoScience
2015
China Medical University
2012-2013
As a novel 2D material, black phosphorus (BP) nanosheets are considered as promising candidate for drug delivery platform synergistic chemo/photothermal therapy. However, the intrinsic instability of bare BP poses challenge in its biomedical applications. To date, some strategies have been employed to prevent from rapid ambient degradation. Unfortunately, most these not suitable systems. Here, simple polydopamine modification method is developed enhance stability and photothermal performance...
Tumor is a severe disease that affects human health. In addition to surgical treatment and radiotherapy, applying therapeutic agents can kill the tumor directly or regulate immune systems one of most common treatments. The current problems these are lacking selective targeting causing unfavorable side effects. order solve develop more effective medicines, nano-carriers employed fabricate smart drug delivery systems. recent years, novel inorganic nano-materials, like mesoporous silica...
Tumor metastasis is one of the big challenges in cancer treatment and often associated with high patient mortality. Until now, there an agreement that tumor invasion are related to degradation extracellular matrix (ECM) by enzymes. Inspired formation natural ECM situ self-assembly strategy developed our group, herein, we constructed artificial (AECM) based on transformable Laminin (LN)-mimic peptide 1 (BP-KLVFFK-GGDGR-YIGSR) for inhibition metastasis. The was composed three modules including...
The restoration of tumor suppressor PTEN by synthetic mRNA nanoparticles sensitizes Pten -null or mutated tumors to immune checkpoint blockade therapy.
Abstract Cerebral amyloid β-peptide (Aβ) accumulation resulting from an imbalance between Aβ production and clearance is one of the most important causes in formation Alzheimer’s disease (AD). In order to preserve maintenance homeostasis have a notable AD therapy, achieving method clear up plaques becomes emerging task. Herein, we describe self-destructive nanosweeper based on multifunctional peptide-polymers that capable capturing clearing for effective treatment AD. The recognize bind via...
A peptide-conjugated poly(β-amino ester) that self-assembles into micelle-like nanoparticles is prepared by a convenient and modular supramolecular approach. The polymer–beclin-1 (P-Bec1) display enhanced cytotoxicity to breast cancer cells through induction of autophagy. This approach overcomes two major limitations the haploinsufficient tumor suppressor Bec1 compared small-molecule drugs: poor delivery tumors owing enzymatic degradation, unstable, non-specific bio-distribution targeting in...
Cisplatin-based chemotherapy is a widely used first-line strategy for numerous cancers. However, drug resistances are often inevitable accompanied by the long-term use of cisplatin in vivo, significantly hampering its therapeutic efficacy and clinical outcomes. Among others, autophagy induction one most common causes tumor resistance to cisplatin. Herein, self-assembled nanoprodrug platform was developed with synergistic effect RNAi fight against cisplatin-resistant lung cancer. The consists...
Autophagy plays a crucial role in the metabolic process. So far, conventional methods are incapable of rapid, precise, and real-time monitoring autophagy living objects. Herein, we describe an situ intracellular self-assembly strategy for quantitative temporal determination objectives. The intelligent building blocks (DPBP) composed by bulky dendrimer as carrier, bis(pyrene) derivative (BP) signal molecule, peptide linker responsive unit that can be cleaved autophagy-specific enzyme, i.e.,...
Au-BP7@SP nanohybrids with active motion under NIR laser irradiation can effectively enhance the temperature of tumor potentially by converting kinetic energy to thermal energy, enhancing killing efficiency cells compared Au@SP. The study provides an insight nanohybrids' effect on photothermal treatment and opens a new avenue cancer using self-propulsion Janus nanohybrids. As service our authors readers, this journal supporting information supplied authors. Such materials are peer reviewed...
Cellular immunotherapeutics aim to employ immune cells as anticancer agents. Ex vivo engineering of dendritic (DCs), the initial role an response, benefits tumor elimination by boosting specific antitumor responses. However, directly activating DCs in is less efficient and therefore quite challenging. Here, we designed a nanoactivator that manufactures through autophagy upregulating directly, which lead high-efficiency antigen presention antigen-specific T generation. The significantly...
Smart nanorobots have emerged as novel drug delivery platforms in nanomedicine, potentially improving anti-cancer efficacy and reducing side effects. In this study, an intelligent tumor microenvironment-responsive nanorobot is developed that effectively delivers CpG payloads to Toll-like receptor 9 (TLR9)-positive tumors induce autophagy-mediated cell death for immunotherapy. The are fabricated by co-self-assembly of two amphiphilic triblock polymer peptides: one containing the matrix...
It is important to develop rapid, accurate, and portable technologies for detecting the freshness of chilled meat meet current demands industry. This report introduces indicators monitoring changes meat, systematically analyzes status existing detection which focus on feasibility using nanozyme sensing detection. Furthermore, it examines limitations foresees future development trends utilizing systems in evaluating freshness. Harmful chemicals are produced by food spoilage degradation,...
Various nanomaterials have been demonstrated as autophagy inducers owing to their endocytosis cell uptake pathway and impairment of lysosomes. pH-dependent drug delivery systems that are capable dissociating in weakly acidic lysosomal environment (pH 4–5) consequently releasing the payloads into cytoplasm paid extensive attention, but autophagy-modulating effects less reported so far. In this study, we report pH-sensitive micelle-like nanoparticles (NPs) self-assembled from poly(β-amino...
Intracellular construction of nanoaggregates from synthetic molecules to mimic natural ordered superstructures has gained increasing attention recently. Here, we develop an endogenous stimuli-induced aggregation (eSIA) approach construct functional for sensing and monitoring cellular physiological processes in situ. We design a series thermosensitive polymer–peptide conjugates (PPCs), which are capable constructing cells based on their isothermal phase transition property. The PPCs composed...
We report a supramolecular approach for preparation of photostable NIR nanovesicles based on cyanine dye derivative as photoacoustic (PA) contrast agent high-performance nano-imaging.
Co-self-assembled vesicular nanoparticles of two structurally comparable amphiphilic boron-dipyrromethene (BODIPY) dyes with dequenchable dual colour fluorescence were prepared for ratiometric imaging live cells.
DOX-encapsulated self-assembled micelle formation by cytotoxic peptide conjugated poly(β-amino ester)s for synergistic cancer chemotherapy.
In drug delivery systems, pH-sensitive polymers are commonly used as carriers, and significant efforts have been devoted to the aspects of controlled release drugs. However, few studies address possible autophagic effects on cells. Here, for first time, using a fluorescent autophagy-reporting cell line, this study evaluates autophagy-induced capabilities four types polymeric nanoparticles (NPs) with different physical properties, including size, surface modification, pH-sensitivity. Based...
Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, only method for PCO treatment precisely focused laser However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens (Nano-IOLs) reported, in which rim of commercially available IOLs (C-IOLs) decorated with silica coated Au nanorods (Au@SiO2 ), high-efficient prevention The Nano-IOLs capable...
A universal strategy for efficient, mild, and purification-free synthesis in situ screening of functional polymer-peptide nanomaterials is described. More than 1000 polymer–peptide conjugates (PPCs) with various chemical structures, compositions, therapeutic efficacy are created. According to this strategy, the structure–function relationship PPCs revealed, antitumor efficacies top performing evaluated vivo. As a service our authors readers, journal provides supporting information supplied...
Urinary tract infections are typical bacterial which result in a number of economic burdens. With increasing antibiotic resistance, it is urgent that new approaches explored can eliminate pathogenic bacteria without inducing drug resistance. Antimicrobial photodynamic therapy (PDT) promising tactic. It gentle situ photochemical reaction photosensitizer (PS) generates reactive oxygen species (ROS) under laser irradiation. In this work, we have demonstrated Chlorin e6 (Ce6) encapsulated...