A5101702509- Marine Bivalve and Aquaculture Studies
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- RNA regulation and disease
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- melanin and skin pigmentation
- Calcium Carbonate Crystallization and Inhibition
- Connexins and lens biology
- Aquaculture Nutrition and Growth
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- interferon and immune responses
- Hair Growth and Disorders
- Dermatologic Treatments and Research
- Algal biology and biofuel production
- Trace Elements in Health
- Pharmaceutical and Antibiotic Environmental Impacts
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Neuroscience and Neuropharmacology Research
- Hydrogels: synthesis, properties, applications
Ministry of Agriculture and Rural Affairs
2023-2025
Huazhong Agricultural University
2025
Agricultural Genomics Institute at Shenzhen
2025
Chinese Academy of Agricultural Sciences
2025
Shanghai Public Health Clinical Center
2025
Wenzhou Medical University
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2025
First Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Guangxi Academy of Fishery Sciences
2018-2024
Tumor metastasis is one of the big challenges in cancer treatment and often associated with high patient mortality. Until now, there an agreement that tumor invasion are related to degradation extracellular matrix (ECM) by enzymes. Inspired formation natural ECM situ self-assembly strategy developed our group, herein, we constructed artificial (AECM) based on transformable Laminin (LN)-mimic peptide 1 (BP-KLVFFK-GGDGR-YIGSR) for inhibition metastasis. The was composed three modules including...
While human cases of highly pathogenic avian influenza A (H5N1) virus infection continue to increase globally, available clinical data on H5N1 are limited. We conducted a retrospective study 26 confirmed identified through surveillance in China from October 2005 April 2008.
A biomimetic peptide recognizes and traps bacteria in vivo as human defensin-6 for inhibiting the invasion of host cells.
ConspectusSelf-assembled nanomaterials show potential high efficiency as theranostic agents for high-performance imaging and therapy. However, superstructures properties of preassembled are somewhat compromised under complicated physiological conditions. Given the advantages dynamic nature adaptive behavior self-assembly systems, we propose an "in vivo self-assembly" strategy in situ construction living objects. For proof-of-concept study self-assembly, developed a bispyrene (BP) molecule...
Platelets play a critical role in the regulation of coagulation, one essential processes life, attracting great attention. However, mimicking platelets for vivo artificial coagulation is still challenge due to complexity process. Here, we design platelet-like nanoparticles (pNPs) based on self-assembled peptides that initiate and form clots blood vessels. The pNPs first bind specifically membrane glycoprotein (i.e., CD105) overexpressed angiogenetic endothelial cells tumor site...
Abstract Stimuli‐responsive DNA hydrogels are promising candidates for cancer treatment, as they not only possess biocompatible and biodegradable 3D network structures highly efficient carriers therapeutic agents but also capable of undergoing programmable gel‐to‐solution transition upon external stimuli to achieve controlled delivery. Herein, a platform photothermal‐chemo synergistic therapy is established by integrating with Ti 3 C 2 T X ‐based MXene photothermal agent doxorubicin (DOX)...
Cancer therapeutic strategies based on angiogenesis attract great attention from fundamental and clinical research. Blocking oxygen nutrition supply to tumor cells could inhibit the growth of tumors occlusion blood vessels in tumor. Herein, we report a dual-responsive peptide-based nanoparticle, mimicking laminin fibrillogenesis specifically highly efficiently vessels, resulting blockage inhibition tumors. The mimic peptide (LMMP) is designed with fibrillation sequence, pH-responsive...
Abstract Crassostrea hongkongensis is a popular and important native oyster species that cultured mainly along the coast of South China Sea. However, absence reference genome has restricted genetic studies development molecular breeding schemes for this species. Here, we combined PacBio 10 × Genomics technologies to create C. assembly, which size 610 Mb, close estimated by flow cytometry (~650 Mb). Contig scaffold N50 are 2.57 4.99 respectively, BUSCO analysis indicates 95.8% metazoan...
Due to their programmable stimuli-responsiveness, excellent biocompatibility, and water-rich soft structures similar biological tissues, smart DNA hydrogels hold great promise for biosensing biomedical applications. However, most developed date are composed of randomly oriented isotropic polymer networks, the resulting slow response biotargets lack anisotropic properties those tissues have limited extensive Herein, consisting unidirectional void channels internally up macroscopic length...
Abstract: To study the clinical and epidemiologic profile of childhood alopecia areata, we performed a survey in which total 226 patients less than 16 years old were enrolled. Statistical analysis heritability using EPI INFO 6.0, SPSS10.0, Falconer method. The median age onset was 10 years. majority (84.96%) presented with limited alopecia. male : female ratio 1.4:1. Boys appeared to have more severe involvement. earlier onset, greater severity disease. Sixty‐seven (29.65%) had previous...
At present, one of main problems for photodynamic therapy (PDT) is how to improve the treatment depth. Two-photon activated (TPA) developed recently provide a possible solution it. In this work, we report energy-transferring assembled cationic dipeptide nanoparticles two-photon (TPA-PDT). nanoparticles, coencapsulated fluorescent dye bis(pyrene) (BP) an energy donor, and photosensitizer rose bengal (RB) acceptor based on intraparticle fluorescence resonance transfer (FRET) mechanism. BP in...
Although shrimp are of great economic importance, few full-length transcriptomes available. Here, we used Pacific Biosciences single-molecule real-time (SMRT) long-read sequencing technology to generate transcripts from the white (Litopenaeus vannamei). We obtained 322,600 non-chimeric reads, which generated 51,367 high-quality unique transcripts. corrected errors in SMRT sequences by comparison with Illumina-produced short reads. successfully annotated 81.72% all against NCBI non-redundant...
Abstract Programmable stimuli‐responsive materials have great potential in biosensing and biomedical applications. However, the slow response of DNA hydrogels to biological targets, especially bio‐macromolecules, i.e., proteins, due mass transfer within hydrogel matrices, as well poor mechanical strength, severely hinders their extensive Herein, construction hierarchically structured exhibiting significantly enhanced responsive properties via a facile cryostructuration process is...
Dyschromatosis symmetrica hereditaria (DSH) is an autosomal dominant pigmentary genodermatosis characterized by hyperpigmented and hypopigmented macules of on the extremities caused mutations in ADAR gene(also called DSRAD) encoding for RNA-specific adenosine deaminase. Here we reported clinical molecular findings 6 Chinese multi-generation families 2 sporadic patients with DSH. We found that same mutation could lead to different phenotypes even family did not establish a clear correlation...
Objective To investigate the value of intratumoral and peritumoral MRI radiomic models in predicting bone metastasis prostate cancer patients using T2WI combined with ADC images. Materials method A total 144 who underwent preoperative (T2WI DWI) were retrospectively included. All categorized into two groups based on presence metastasis. The radiomics features calculatd for entire tumor 3mm-peritumoral components pre-processed features, as well their merged respectively constructed....
Background: Functional alleles of host plant susceptibility genes (S genes) can exacerbate the severity diseases by enhancing pathogen compatibility. Genetic editing targeted S has demonstrated remarkable efficacy in conferring broad-spectrum resistance across multiple crop species. We have previously identified a Golgi-localized Nucleotide Sugar Transporter 1 homolog (SlGONST1.1) Solanum lycopersicum as gene towards late blight caused Phytophthora infestans. Methods: In this study, we...