A5007506717- Nanoplatforms for cancer theranostics
- Metal-Organic Frameworks: Synthesis and Applications
- Extracellular vesicles in disease
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Antibiotic Resistance in Bacteria
- Magnetism in coordination complexes
- Molecular Sensors and Ion Detection
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Liver physiology and pathology
- Vitamin K Research Studies
- Salmonella and Campylobacter epidemiology
- 2D Materials and Applications
- 3D Printing in Biomedical Research
- Bacteriophages and microbial interactions
- Vitamin C and Antioxidants Research
- Pluripotent Stem Cells Research
- Dendrimers and Hyperbranched Polymers
- Luminescence and Fluorescent Materials
- Advanced Nanomaterials in Catalysis
- Antimicrobial Peptides and Activities
- Metal complexes synthesis and properties
- Pancreatitis Pathology and Treatment
- Supramolecular Self-Assembly in Materials
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Shanxi Medical University
2017-2024
Hunan University
2023-2024
Jiangsu University
2022
Industrial and Commercial Bank of China
2022
Yan'an University
2022
Sun Yat-sen University
2018-2020
University of Shanghai for Science and Technology
2020
Shihezi University
2020
Nanjing Tech University
2016-2019
As a novel 2D material, black phosphorus (BP) nanosheets are considered as promising candidate for drug delivery platform synergistic chemo/photothermal therapy. However, the intrinsic instability of bare BP poses challenge in its biomedical applications. To date, some strategies have been employed to prevent from rapid ambient degradation. Unfortunately, most these not suitable systems. Here, simple polydopamine modification method is developed enhance stability and photothermal performance...
Abstract Black phosphorus (BP) has increasingly attracted scientific attention since its first applications in biomedicine due to unique properties and excellent biocompatibility. In particular, layer‐dependent bandgap, moderate carrier mobility, large surface‐area‐to‐volume ratio, biodegradability, intrinsic photoacoustic properties, biocompatibility make it an ideal candidate for use photothermal therapy, photodynamic drug delivery, 3D printing, bioimaging, biosensing, theranostics, which...
Human serum albumin (HSA) based drug delivery platforms that feature desirable biocompatibility and pharmacokinetic property are rapidly developed for tumor-targeted delivery. Even though various HSA-based have been established, it is still of great significance to develop more efficient preparation technology broaden the therapeutic applications nano-carriers. Here we report a bridging strategy unfastens HSA polypeptide chains subsequently crosslinks these by bridge-like molecule (BPY-Mal2)...
A new ZnII metal-organic framework, [Zn6 (L)3 (DMA)4 ]⋅5 DMA (H4 L=[1,1':3',1''-terphenyl]-3,3'',5,5''-tetracarboxylic acid, DMA=dimethylacetamide), has been synthesized and characterized. The structure contains a three-dimensional 3,4,4,6-connected net with (4.62 )2 (66 )(66 )(42 .610 .83 ) topology displays selective detection of nitrobenzene, CrO42- Fe3+ ions. present work thus indicates that this framework could be prospective candidate for developing novel luminescence sensors the...
Due to the inherent limitations, single chemo or photothermal therapies (PTT) are always inefficient. The combination of chemotherapy and PTT for treatment cancers has attracted a great interest during past few years. As agent, black phosphorus quantum dots (BPQDs) possess an excellent extinction coefficient, high conversion efficacy, good biocompatibility. Herein, we developed photo- pH-sensitive nanoparticle based on BPQDs targeted chemo-photothermal therapy. Doxorubicin (DOX) was employed...
Abstract The construction of bioartificial livers, such as liver organoids, offers significant promise for disease modeling, drug development, and regenerative medicine. However, existing methods generating organoids have limitations, including lengthy complex processes (taking 6–8 weeks or longer), safety concerns associated with pluripotency, limited functionality pluripotent stem cell‐derived hepatocytes, small, highly variable sizes (typically ≈50–500 µm in diameter). Prolonged culture...
Abstract: The development of versatile nanoscale drug delivery systems that integrate with multiple therapeutic agents or methods and improve the efficacy cancer therapy is urgently required. To satisfy this demand, polydopamine (PDA)-modified polymeric nanoplatforms were constructed for dual loading chemotherapeutic drugs. hydrophobic anticancer docetaxel (DTX) was loaded into nanoparticles (NPs) which fabricated from star-shaped copolymer CA-PLGA. Then DTX-loaded NPs coated PDA, followed...
The ability to accurately characterize microorganism distribution in the intestinal tract is helpful for understanding intrinsic mechanisms. Within intestine, traditional optical probes used labeling commonly suffer from a low imaging penetration depth and poor resolution. We report novel observation tool useful microbial research by near-infrared-IIb (NIR-IIb, 1500–1700 nm) lanthanide nanomaterials NaGdF4:Yb3+,Er3+@NaGdF4,Nd3+ (Er@Nd NPs) onto surface of Lactobacillus bulgaricus (L....
The utilization of three-dimensional (3D) bioprinting technology to create a transplantable bioartificial liver emerges as promising remedy for the scarcity donors. This study outlines our strategy constructing 3D-bioprinted liver, using in vitro–expanded primary hepatocytes recognized their safety and enhanced functional robustness hepatic cell sources construction. In addition, we have developed bioink biomaterials with mechanical rheological properties, well printing capabilities,...
Addressing the global challenge of bacterial resistance demands innovative approaches, among which multitargeting is a widely used strategy. Current strategies multitargeting, typically achieved through drug combinations or single agents inherently aiming at multiple targets, face challenges such as stringent pharmacokinetic and pharmacodynamic requirements cytotoxicity concerns. In this report, we propose bacterial-specific disruption approach vastly expanded strategy that effectively...
To investigate the effect of a social media platform for treatment Helicobacter pylori infection.We enrolled 222 patients from October 2018 to June 2019, who required H therapy. We used WeChat, platform, as patient reminder tool. They were randomly divided into intervention and control groups (n = 111 per group) compare evaluate their disease awareness, medication adherence, incidence adverse drug reactions, eradication rate.Patients in group had significantly better disease-related...
The development of advanced in vitro models for assessing liver toxicity and drug responses is crucial personalized medicine preclinical development. 3D bioprinting technology provides opportunities to create human that are suitable conducting high-throughput screening toxicity. In this study, we fabricated a humanized model using human-induced hepatocytes (hiHeps) derived from fibroblasts via rapid efficient reprogramming process. These hiHeps were then employed bioprinted with bioink...
Prostate cancer is the second most common malignancy among men worldwide. However, conventional chemotherapy, such as taxane therapy, fails to exhibit efficient treatment for almost half of patients. In this study, a nano-drug delivery system based on black phosphorus nanosheets (BP NSs) was developed, which then employed multifunctional nanoplatform targeted combinational chemo-photothermal therapy against prostate cancer. Zinc ion (Zn2+), has been proven be able inhibit cell proliferation,...
Manganese (Mn) is a common environmental pollutant. Mn exposure can lead to neurodegenerative diseases resembling Parkinson's disease, and has become major public health concern. However, the mechanism of Mn-induced neurotoxicity in brain not clear. Fecal microbiome transplantation (FMT) may alleviate by remodeling gut microbiota. In this study, MnCl2 (manganese chloride) was administered mice as drinking water (Mn: 200 mg/L), fecal matter from donor oral gavage every other day recipient...
Highly fluoroquinolone-resistant Salmonella enterica serotype Kentucky has become widespread in recent years, largely associated with the spread of sequence type 198 (ST198), which often leads to multidrug resistance. Research on genomic epidemiology China is currently uncommon. In this study, we analysed and antimicrobial resistance characteristics ST198 collected from foodborne disease surveillance Shenzhen, China, during 2010-2021, using whole-genome sequencing antibiotic susceptibility...
The metal‐organic frameworks (MOFs), {[Cd(L)(H 2 O)] · CH 3 OH DMF} ( 1 ) and [Pb(L)(DMF)] (L = 2,4‐dihydroxybenzaldehyde nicotinoylhydrazone), were synthesized characterized using microanalyses, IR spectroscopy, single‐crystal X‐ray diffraction. Single crystal analyses revealed that both exhibit 2D grid networks. photoluminescence investigation indicates could be a prospective candidate for developing luminescencent sensors the selective sensing of nitrobenzene, which is used as precursor...
Protein kinase-mediated phosphorylation plays a critical role in many biological processes. However, the identification of key regulatory kinases is still great challenge. Here, we develop trans-omics-based method, central kinase inference, to predict potentially by integrating quantitative transcriptomic and phosphoproteomic data. Using known associated with anti-cancer drug resistance, accuracy our method denoted area under curve 5.2% 29.5% higher than Kinase-Substrate Enrichment Analysis....