A5074406685- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Synthesis and Catalysis
- HER2/EGFR in Cancer Research
- Synthetic Organic Chemistry Methods
- Synthesis and Catalytic Reactions
- Monoclonal and Polyclonal Antibodies Research
- Catalytic Alkyne Reactions
- Asymmetric Hydrogenation and Catalysis
- Cytokine Signaling Pathways and Interactions
- Melanoma and MAPK Pathways
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Crystallography and molecular interactions
- Oxidative Organic Chemistry Reactions
- Carbohydrate Chemistry and Synthesis
- Multicomponent Synthesis of Heterocycles
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Advanced Biosensing Techniques and Applications
- Synthesis and Biological Evaluation
- Fluorine in Organic Chemistry
Sichuan University
2005-2025
West China Hospital of Sichuan University
2024-2025
Florida State University
2024-2025
Sun Yat-sen University
2014-2025
Yanshan University
2024-2025
Children's Hospital of Capital Institute of Pediatrics
2025
National High Magnetic Field Laboratory
2025
Integrated Optoelectronics (Norway)
2025
Hunan University
2025
Second Xiangya Hospital of Central South University
2025
Multicomponent reactions (MCRs) are one-pot processes in which three or more starting materials form a product that incorporates the structural features of each reagent. These date back to mid-19th century, when Strecker first prepared α-aminonitriles through condensation aldehydes with ammonia and hydrogen cyanide. In addition affording products complexity diversity, MCRs offer advantages simplicity, synthetic efficiency, convergence, atom economy. Therefore, they have played an important...
An asymmetric three-component reaction of diazo compounds and alcohols with imines catalyzed cooperatively by a rhodium complex chiral Brønsted acid provides general efficient entry to β-amino-α-hydroxyl derivatives in high yields excellent stereoselectivities.
Abstract There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC). It necessary to investigate the therapeutic efficacy safety of TACE combined with PD-(L)1 inhibitors MTT real-world situations. In this nationwide, retrospective, cohort study, 826 HCC patients receiving either plus blockades (combination group, n = 376) or monotherapy...
The diastereoselectively switchable enantioselective trapping of protic carbamate ammonium ylides with imines is reported. intriguing Rh(2)(OAc)(4) and chiral Brønsted acid cocatalyzed three-component Mannich-type reaction a diazo compound, carbamate, an imine provides rapid efficient access to both syn- anti-α-substituted α,β-diamino derivatives high level control chemo-, diastereo-, enantioselectivity.
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNovel Spiro Phosphinite Ligands and Their Application in Homogeneous Catalytic Hydrogenation ReactionsAlbert S. C. Chan, Wenhao Hu, Cheng-Chao Pai, Chak-Po Lau, Yaozhong Jiang, Aiqiao Mi, Ming Yan, Jian Sun, Rongliang Lou, Jingen DengView Author Information Union Laboratory of Asymmetric Synthesis Department Applied Biology Chemical Technology The Hong Kong Polytechnic University, Chengdu Institute Organic Chemistry Academia Sinica, Chengdu,...
Reaction trio: The title reaction delivers CH functionalized pyrrole derivatives in moderate to good yields. This novel three-component provides both syn- and anti-pyrrole having two contiguous stereocenters with regio-, diastereo-, enantioselectivity. process represents the first highly enantioselective palladium-carbenoid-mediated reaction. As a service our authors readers, this journal supporting information supplied by authors. Such materials are peer reviewed may be re-organized for...
Abstract Asymmetric functionalization of aromatic CH bonds N,N‐disubstituted anilines with diazo compounds and imines is reported for the efficient construction α,α‐diaryl benzylic quaternary stereocenters in good yields high diastereoselectivities excellent enantioselectivities. This Rh II /chiral phosphoric acid cocatalyzed transformation proposed to proceed through a metal‐carbene‐induced zwitterionic intermediate which undergoes electrophilic trapping. To best our knowledge, this first...
A novel enantioselective aminomethylation reaction of diazo compound, alcohol and α-aminomethyl ether enabled by asymmetric counteranion-directed catalysis is disclosed that offers an efficient convenient access to furnish optically active α-hydroxyl-β-amino acids in high yield with excellent enantioselectivities. Control experiments DFT calculations indicate the transformation proceeds through trapping situ generated enol intermediate methylene iminium ion, induction was chiral...
Triazoles with fused-heterocycle nuclei were designed and evaluated for their in vitro activity on the basis of binding mode albaconazole using molecular docking, along SAR antifungal triazoles. Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine tetrahydro-thiazolo[5,4-c]pyridine preferable to other four investigated. Potent activity, broad spectrum better water solubility attained when triazoles containing nitrogen aromatic heterocycles attached these two nuclei. The most potent compounds 27aa 45x,...
Statistical inference on conditional dependence is essential in many fields including genetic association studies and graphical models. The classic measures focus linear correlations, are incapable of characterizing non-linear relationship non-monotonic relationship. To overcome this limitation, we introduces a nonparametric measure for multivariate random variables with arbitrary dimensions. Our possesses the necessary intuitive properties as correlation index. Briefly, it zero almost...
Abstract The chiral Rh I –diene‐catalyzed asymmetric three‐component reaction of aryldiazoacetates, aromatic amines, and β‐nitroacrylates was achieved to obtain γ‐nitro‐α‐amino‐succinates in good yields with high diastereo‐ enantioselectivity. This is proposed proceed through the enantioselective trapping ‐associated ammonium ylides by nitroacrylates. new transformation represents first example ‐carbene‐induced ylide transformation.
An enantioselective Mannich-type reaction of 3-butynol and nitrones is described, which affords dihydrofuran-3-ones in good yields with excellent enantioselectivities. The initiated by gold-catalyzed alkyne oxidation modification the resulting gold carbene species a tethered hydroxy group to form enolate species; terminates an addition assistance chiral phosphoric acid (CPA) hydrogen bonding. This novel pattern transformation involving chemical bond cleavage, fragment reassembly process,...
Chemical bond cleavage and reconstruction are common processes in traditional rearrangement reactions. In contrast, the process that involves cleavage, fragment modification then of modified provides an efficient way to build structurally diversified molecules. Here, we report a palladium(II)/chiral phosphoric acid catalysed three-component reaction aryldiazoacetates, enamines imines afford α-amino-δ-oxo pentanoic derivatives good yields with excellent diastereoselectivities high...
Constitutive activation of signal transducer and activator transcription 3 (STAT3) is a common feature in human non-small cell lung cancer (NSCLC).STAT3 plays an important role progression as driver oncogene acquired resistance targeted therapies alternatively activated pathway.W2014-S with pharmacophore structure imidazopyridine, which was firstly reported to be utilized STAT3 inhibitor discovery, screened out potent from library small molecules.The aim this study investigate the antitumor...
Multicomponent reactions that involve interception of onium ylides through Aldol, Mannich, and Michael addition with corresponding bench-stable acceptors have demonstrated broad applications in synthetic chemistry. However, because the high reactivity transient survival these situ generated intermediates, substitution-type process, especially asymmetric catalytic version, remains hitherto unknown. Herein, a three-component allylation α-diazo carbonyl compounds alcohols allyl carbonates is...
Abstract Enantioselective α -aminomethylation of carbonyl compounds constitutes a powerful protocol for introducing aminomethyl groups to simple organic molecules. However, current strategies rely on nucleophile-based enantioselective activation with inherently activated substrates only, and based the in situ-generated unstable formaldimines remains elusive, probably owing their nature lack steric environment efficient stereocontrols. Here, rhodium/chiral phosphoric acid cooperative...
Catalytic oxidative functionalization of alkynes has emerged as an effective method in synthetic chemistry recent decades. However, enantioselective transformations via metal carbene intermediates are quite rare due to the lack robust chiral catalysts, especially intermolecular versions. Herein, we report first asymmetric three-component reaction commercially available with nitrones and alcohols, which affords α-alkoxy-β-amino-ketones good yields high excellent enantioselectivity using...
Abstract Metal carbene is an active synthetic intermediate, which has shown versatile applications in chemistry. Although a variety of catalytic methods have been disclosed for the generation species from different precursors, there increasing demand development efficient and practical approaches in-situ formation metal intermediates with structural diversity unrevealed reactivity. Herein we report gold-catalyzed cascade protocol assembly polycarbocyclic frameworks high yields under mild...
Based on the strategy of polarity reversal in generation free radicals derived from diazo compounds, photocatalyzed multicomponent reactions (MCRs) nitrogen aromatic heterocycles, alkenes, and compounds form functionalized derivatives good to high yields exacting regioselectivities. The carbon generated acceptor are electrophilic, their selective additions with alkenes provide nucleophilic radicals, which enable further rapid assembly various heteroarenes. A delicate balance has been...