A5019253173- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Synthesis and Catalytic Reactions
- Asymmetric Hydrogenation and Catalysis
- Microbial Metabolic Engineering and Bioproduction
- Polysaccharides and Plant Cell Walls
- Carbon and Quantum Dots Applications
- Microbial Community Ecology and Physiology
- Photosynthetic Processes and Mechanisms
- Sulfur-Based Synthesis Techniques
- Advanced biosensing and bioanalysis techniques
- Catalytic Alkyne Reactions
- Asymmetric Synthesis and Catalysis
- Nanoplatforms for cancer theranostics
- Sphingolipid Metabolism and Signaling
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Fungal Biology and Applications
- Perovskite Materials and Applications
- Peer-to-Peer Network Technologies
- Cell death mechanisms and regulation
- Retinoids in leukemia and cellular processes
- Radical Photochemical Reactions
- Traditional Chinese Medicine Analysis
Sun Yat-sen University
2017-2024
Huanggang Normal University
2015-2024
Yantai University
2024
Qufu Normal University
2024
Nanjing Agricultural University
2024
Scripps (United States)
2020
Scripps Institution of Oceanography
2020
Torrey Pines Institute For Molecular Studies
2020
State Council of the People's Republic of China
2017
Center of Hubei Cooperative Innovation for Emissions Trading System
2015
Multicomponent reactions that involve interception of onium ylides through Aldol, Mannich, and Michael addition with corresponding bench-stable acceptors have demonstrated broad applications in synthetic chemistry. However, because the high reactivity transient survival these situ generated intermediates, substitution-type process, especially asymmetric catalytic version, remains hitherto unknown. Herein, a three-component allylation α-diazo carbonyl compounds alcohols allyl carbonates is...
DNA encoded libraries (DEL) have shown promise as a valuable technology for democratizing the hit discovery process. Although DEL provides relatively inexpensive access to of unprecedented size, their production has been hampered by idiosyncratic needs encoding tag relegating compatible chemistry dilute aqueous environments. Recently reversible adsorption solid support (RASS) demonstrated promising method expand reactivity using standard organic synthesis protocols. Here we demonstrate suite...
To explore potential chemical space using DNA-encoded library (DEL) technology, the development of various types robust DNA-compatible reactions is urgently needed. Diazo compounds, which serve as valuable building blocks and important synthons in synthetic chemistry, have been rarely applied DEL synthesis, probably because their modifications bases phosphate backbone DNA. Herein we report two cases with alkenes diazo providing corresponding hydroalkylation cyclopropanation products moderate...
The constructed nanoparticles solved the aggregation, low solubility and poor selectivity of zinc phthalocyanine along with high singlet oxygen yield.
Abstract Pyridinium ylide is a versatile building block in synthetic organic chemistry, especially the synthesis of N ‐heterocycles. In this minireview, we have summarized advances [3+2]‐cycloaddition catalytically generated pyridinium for indolizines (since 1970s). Accordingly, discussed article situ from carbene precursors and ‐heteroarenes under catalytic conditions, including photocatalysis/thermocatalysis, metal‐catalysis. The metal‐catalyzed version main focus, which classified based...
A series of novel compounds bearing a cyclopropyl linkage were designed, synthesized, and evaluated as programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors. An optimized compound (1S,2S)-A25 showed potent inhibitory activity against the PD-1/PD-L1 interaction (IC50 = 0.029 μM) with selected binding affinity PD-L1 (KD 1.554 × 10–1 μM). Additionally, under co-culture H460/Jurkat cells, can reduce survival H460 cells in concentration-dependent way. liver microsomal assay...
Developing an efficient and highly enantioselective protocol to access homopropargyl amines is of high interest the synthetic community also remains a formidable challenge for organic chemists. Here, we present integrated Rh2(OAc)4- BINOL-derived chiral phosphoric acid cooperatively catalyzed three-component reactions alkynyldiazoacetates, imines with various nucleophiles including alcohols, indoles, N,N-disubstituted anilines, affording corresponding containing two vicinal centers in...
A photoredox-catalyzed reaction of secondary amines, aldehydes, diazo compounds, and Hantzsch ester is reported, affording biologically active γ-amino acid derivatives in high yields. This one-pot process tolerates a broad range functional groups various drug molecules compounds. Remarkably, gram-scale diverse transformations were successfully performed, the utility products demonstrated synthesis therapeutic agent pregabalin.
A DNA-compatible three-component reaction is disclosed for the synthesis of on-DNA polysubstituted isoxazolidines that serve as privileged core scaffolds in numerous natural products and bioactive molecules. This one-pot approach involves 1,3-dipolar cycloaddition DNA-tagged styrenes with diazo compounds nitrosoarenes an aqueous solution KOAc. The demonstrates excellent functional group compatibility, providing a conventional protocol construction DNA-labeled isoxazolidine library.
Paclitaxel (Taxol@) as a cornerstone of chemotherapy remains in high demand. The semi-synthesis paclitaxel via coupling Taxus leaf-produced baccatin III and manually synthesized isoserine (C-13 side chain) is one the solutions to avoid environmental damage caused by sacrifice whole brevifolia. A green synthesis C-13 chain pivotal production paclitaxel. We herein report derivatives straightforward assembly isoserines based on an Rh2(TPA)3(OAc)/CPA1 co-catalyzed asymmetric multi-component...
N-(Anthrancen-9-ylmethyl) isoserines are useful drug intermediates but short for efficient synthesis. We herein report the synthesis of N-(anthrancen-9-ylmethyl) via a Rh2(Ph3COO)3(OAc) and chiral phosphoric acid (CPA) synergistically catalyzed multicomponent reaction (MCR) N-alkyl imines, alcohols, diazoesters. The method representing first example imines-involved MCR is featured by high atom-economy, diastereo- enantioselectivities, broad substrate scope. DFT calculations on mechanism...
Abstract DNA encoded libraries (DEL) have shown promise as a valuable technology for democratizing the hit discovery process. Although DEL provides relatively inexpensive access to of unprecedented size, their production has been hampered by idiosyncratic needs encoding tag relegating compatible chemistry dilute aqueous environments. Recently reversible adsorption solid support (RASS) demonstrated promising method expand reactivity using standard organic synthesis protocols. Here we...
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Polygonati Rhizoma, a functional food and traditional Chinese medicine broadly used in China several Southeast Asia countries, possesses effective health-promoting activities. Prepared from three<em> </em>plants in<em> Polygonatum </em>family (<em>P. kingianum</em>, <em>P. sibiricum</em>, cyrtonema</em>), Rhizoma has drawn increasing attention due to its remarkable immune-enhancing metabolic regulatory activities recent years. In this review, we summarized the updated research of chemical...
Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is the key enzyme to assimilate CO 2 into biosphere. The structural and evolutionary relationships among RuBisCOs were discussed at domain level. nonredundant sets for three superfamilies of RuBisCO, i.e. large subunit C-terminal (LSC), N-terminal (LSN) small (SS) defined using QR factorization based on alignment RuBisCO domains with QH as similarity measure, respectively. results suggest: (1) core structures LSC, LSN SS are well...
Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is the key enzyme to assimilate CO 2 into biosphere. The structural and evolutionary relationships among RuBisCOs were discussed at domain level. nonredundant sets for three superfamilies of RuBisCO, i.e. large subunit C-terminal (LSC), N-terminal (LSN) small (SS) defined using QR factorization based on alignment RuBisCO domains with QH as similarity measure, respectively. results suggest: (1) core structures LSC, LSN SS are well...