A5023560466- Nanoplatforms for cancer theranostics
- interferon and immune responses
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Immune cells in cancer
- Chemokine receptors and signaling
- Oral and Maxillofacial Pathology
- Viral Infections and Vectors
- Erythrocyte Function and Pathophysiology
- Immune Response and Inflammation
- Bone health and treatments
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Photoacoustic and Ultrasonic Imaging
- Proteins in Food Systems
- Protein Hydrolysis and Bioactive Peptides
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Microencapsulation and Drying Processes
- Extracellular vesicles in disease
- CRISPR and Genetic Engineering
Icahn School of Medicine at Mount Sinai
2024-2025
Shanxi Agricultural University
2025
Tisch Hospital
2025
University of Michigan
2018-2024
BioSurfaces (United States)
2018-2024
Jining Medical University
2024
Moffitt Cancer Center
2024
Anhui Medical University
2023
Peking University
2008-2022
Beijing Jishuitan Hospital
2008-2022
Abstract Herein, an intelligent biodegradable hollow manganese dioxide (H-MnO 2 ) nano-platform is developed for not only tumor microenvironment (TME)-specific imaging and on-demand drug release, but also modulation of hypoxic TME to enhance cancer therapy, resulting in comprehensive effects favoring anti-tumor immune responses. With structures, H-MnO nanoshells post modification with polyethylene glycol (PEG) could be co-loaded a photodynamic agent chlorine e6 (Ce6), chemotherapy...
Tumor vaccines for cancer prevention and treatment have attracted tremendous interests in the area of immunotherapy recent years. In this work, we present a strategy to construct by encapsulating immune-adjuvant nanoparticles with cell membranes modified mannose. Poly(d,l-lactide-co-glycolide) are first loaded toll-like receptor 7 agonist, imiquimod (R837). Those adjuvant (NP-R) then coated (NP-R@M), whose surface proteins could act as tumor-specific antigens. With further modification...
Significance Hydrogen peroxide is closely associated with many important physiological and pathological events. Herein, we develop a liposomal nanoprobe for in vivo H 2 O -responsive chromogenic assay, which highly specific sensitive to . Using such nanoprobe, photoacoustic imaging of -related inflammation processes mice induced by either LPS or bacteria realized. Meanwhile, reacting endogenous produced tumor cells, allows early-stage small tumors orthotopic brain glioma even enables...
A novel type of bio-nanoreactor with catalase loaded inside TaOx hollow nanoshells is fabricated via a mild one-step method. Such bio-nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen decomposition endogenic H2O2 in microenvironment, and thus synergistically enhance efficacy cancer radiotherapy both depositing radiation energy within overcoming hypoxia-induced resistance. As service to our authors readers, this journal provides supporting information supplied...
Cancer combination therapy to treat tumors with different therapeutic approaches can efficiently improve treatment efficacy and reduce side effects.Herein, we develop a theranostic nano-platform based on polydopamine (PDA) nanoparticles, which then are exploited as versatile carrier allow simultaneous loading of indocyanine green (ICG), doxorubicin (DOX) manganese ions (PDA-ICG-PEG/DOX(Mn)), enable imaging-guided chemo & photothermal cancer therapy.In this system, ICG acts agent, shows...
Red blood cells are attached to iron oxide nanoparticles pre-coated with chlorine e6, a photosensitizer, and then loaded chemotherapeutic drug, doxorubicin, enable imaging-guided combined photodynamic chemotherapy of cancer, achieving excellent synergistic therapeutic effects in an animal tumor model. This work highlights the great promise integrating cell-based drug-delivery systems nanotechnology as biocompatible multifunctional platform for applications cancer theranostics. As service our...
Red blood cells (RBCs), the “innate carriers” in vessels, are gifted with many unique advantages drug transportation over synthetic delivery systems (DDSs). Herein, a tumor angiogenesis targeting, light stimulus‐responsive, RBC‐based DDS is developed by incorporating various functional components within RBC platform. An albumin bound near‐infrared (NIR) dye, together chemotherapy doxorubicin, encapsulated inside RBCs, surfaces of which modified targeting peptide to allow cancer targeting....
The cGAS-STING pathway plays a crucial role in innate immune activation against cancer and infections, STING agonists based on cyclic dinucleotides (CDN) have garnered attention for their potential use immunotherapy vaccines. However, the limited drug-like properties of CDN necessitate an efficient delivery system to system. To address these challenges, we developed immunostimulatory agonists. Here, examined aqueous coordination interactions between metal ions report that mixed with Zn2+...
Abstract Advanced drug delivery systems are widely considered to be powerful approaches for treating cancer and many other diseases because of their superior ability improve pharmacokinetics, promote lesion‐targeted efficacy, and/or reduce the toxic effects diverse therapeutics. Owing unique biomimetic structure lipid bilayers surrounding aqueous cavities, liposomes have been found encapsulate various therapeutics, ranging from small molecules with different hydrophobicities...
In this study, gold nanorods (GNRs) were incorporated into the hydrogel networks formed by copolymerization of N-isopropylacrylamide (NIPAm) and methacrylated poly-β-cyclodextrin (MPCD)-based macromer to fabricate an injectable near-infrared (NIR)/pH-responsive poly(NIPAm-co-MPCD)/GNRs nanocomposite hydrogel, which could serve as a long-acting implant for chemophotothermal synergistic cancer therapy. The showed superior mechanical swelling properties, gelation characteristics, excellent...
Smart drug delivery systems with on‐demand release capability are rather attractive to realize highly specific cancer treatment. Herein, a novel light‐responsive platform based on photosensitizer chlorin e6 (Ce6) doped mesoporous silica nanorods (CMSNRs) is developed for light‐triggered release. In this design, CMSNRs coated bovine serum albumin (BSA) via singlet oxygen (SO)‐sensitive bis‐(alkylthio)alkene (BATA) linker, and then modified polyethylene glycol (PEG). The obtained...
Prussian blue (PB) as a clinically adapted agent recently has drawn much attention in cancer theranostics for potential applications magnetic resonance (MR) imaging well photothermal treatment. In this work, we take closer look at the and therapy performance of PB agents once they are doped with Mn2+. It is found that Mn2+-doped nanocubes exhibit increased longitudinal relaxivity along enhanced optical absorption red-shifted to near-infrared (NIR) region. Those properties make PB:Mn...
Recent studies have shown that certain combinations of Toll-like receptor (TLR) agonists can induce synergistic immune activation. However, it remains challenging to achieve such robust responses in vivo a manner is effective, facile, and amenable for clinical translation. Here, we show MPLA, TLR4 agonist, CpG, TLR9 be efficiently co-loaded into synthetic high-density lipoprotein nanodiscs, forming potent adjuvant system (ND-MPLA/CpG) readily combined with variety subunit antigens, including...
Recently, the development of nano‐theranostic agents aiming at imaging guided therapy has received great attention. In this work, a near‐infrared (NIR) heptamethine indocyanine dye, IR825, in presence cationic polymer, polyallylamine hydrochloride (PAH), forms J‐aggregates with red‐shifted and significantly enhanced absorbance. After further complexing ultra‐small iron oxide nanoparticles (IONPs) followed functionalization polyethylene glycol (PEG), obtained IR825@PAH‐IONP‐PEG composite are...
Adoptive T cell immunotherapy, such as chimeric antigen receptor (CAR) therapy, has proven to be highly efficient in the treatment of hematologic malignancies. However, it is challenged by complicated ex vivo engineering, systemic side effects, and low expression tumor-specific antigen, especially solid tumors. In this paper, we present a "recognition-then-activation" strategy, which first assists naïve cells recognize adhere cancer then activates accumulated situ specifically kill cells....
While cancer immunotherapy provides new exciting treatment options for patients, there is an urgent need strategies that can synergize with immune checkpoint blockers and boost the patient response rates. We have developed a personalized vaccine nanodisc platform based on synthetic high-density lipoproteins co-delivery of immunostimulatory agents tumor antigens, including tumor-specific neoantigens. Here we examined route delivery, safety profiles, therapeutic efficacy vaccination against...