A5052957670- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Immune cells in cancer
- Pediatric health and respiratory diseases
- Viral Infections and Vectors
- interferon and immune responses
- Chronic Myeloid Leukemia Treatments
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Parasitic Infections and Diagnostics
- Connective tissue disorders research
- Amphibian and Reptile Biology
- Food Allergy and Anaphylaxis Research
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Protease and Inhibitor Mechanisms
- Cutaneous lymphoproliferative disorders research
University of Michigan
2021-2024
BioSurfaces (United States)
2022-2024
University of Wisconsin–Madison
2019-2022
University of Rhode Island
2019
Ninewells Hospital
1994-1999
University of Dundee
1994-1999
Abstract Despite significant advances in immune checkpoint blockade (ICB), immunosuppression mediated by tumor-associated myeloid cells (TAMCs) poses a major barrier to cancer immunotherapy. In addition, while immunogenic cell death (ICD) provides viable approach inducing anti-tumor response, it remains unknown how effectively trigger ICD addressing immunosuppressive TAMCs. Here, we show that SC144, gp130 inhibitor blocks the IL-6/gp130/STAT3 pathway, induces of tumor and polarizes...
Abstract White-nose syndrome (WNS) caused by the fungus, Pseudogymnoascus destructans ( Pd ) has killed millions of North American hibernating bats. Currently, methods to prevent disease are limited. We conducted two trials assess potential WNS vaccine candidates in wild-caught Myotis lucifugus . In a pilot study, we immunized bats with one four treatments or phosphate-buffered saline (PBS) as control and challenged them upon transfer into hibernation chambers. Bats vaccine-treated group,...
Blastomycosis is a potentially life-threatening infection caused by the fungus Blastomyces dermatitidis . As with related fungal diseases, blastomycosis noted to affect some populations more than others. These patterns of illness are often not predisposing conditions or exposure risks; thus, genetic differences thought underlie these health disparities. People Hmong ancestry in Wisconsin at elevated risk compared general population. We studied codes patients and identified candidate sites...
AbstractHuman fibrillin, a major component of the extracellular matrix, exists as two highly homologous forms (fibrillin-1 and -2). Several modules fibrillin are to TGF-β1 binding protein. Two these modules, D25 (the 25th module fibrillin-1 -2 D segment) D12 12th fibrillin-2 contain cell adhesion motif arginyl-glycyl-aspartyl (RGD). The ability RGD mediate D25-1 D12-2 was investigated using bacterially expressed fusion proteins. Human skin fibroblasts murine L-cells were used in microassays...
The development of effective vaccines against fungal infections requires the induction protective, pathogen-specific cell-mediated immune responses. Here, we asked whether combination adjuvants based on delta inulin (Advax) formulated with Toll-like receptor (TLR) agonists could improve vaccine protection mediated by a recombinant protein, Bl-Eng2 (i.e., Blastomyces endoglucanase 2), which itself harbors an immunodominant antigen and dectin-2 agonist/adjuvant. We found that Advax3 containing...
The distribution of a range integrins, E-cadherin, and carcino-embryonic antigen (CEA) like molecules in normal human oesophageal epithelium was investigated immunohistochemically on frozen sections endoscopic biopsy specimens. integrin subunits alpha 2, 3, 6, v, beta 1, 5 were expressed throughout the epithelium. There strong expression 1 basal cell layer for all studied intensity staining decreased as cells moved towards lumen. heterodimer v 3 weakly aspect only. CEA not present but there...
The development of safe subunit vaccines requires adjuvants that augment immunogenicity non-replicating protein-based antigens. Current against infectious diseases preferentially induce protective antibodies driven by such as alum. However, the contribution antibody to host defense is limited for certain classes fungi, whereas animal studies and clinical observations implicate cellular immunity an essential component resolution fungal pathogens. Here, we decipher structural bases a newly...
// Hannah E. Dobson 1 , Shasha Ruan 2 Alfred Chang Max S. Wicha and Qiao Li Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA Department Clinical Oncology, Renmin Hospital Wuhan University, Wuhan, Hubei 430060, China Correspondence to: Li, email: qiaoli@umich.edu Keywords: cancer stem cells; ITGβ4; dendritic cell vaccine; bispecific antibody; T cells Received: April 15, 2021 Accepted: May 13, Published: August 31, Copyright: © et al. This is an open access article...
Memory T cells underpin vaccine-induced immunity but are not yet fully understood. To distinguish features of memory that confer protective immunity, we used single cell transcriptome analysis to compare antigen-specific CD4+T recalled lungs mice received a or nonprotective subunit vaccine followed by challenge with fungal pathogen. We unexpectedly found populations specific protection expressed strong type I interferon response signature, whose distinctive transcriptional signature appeared...
Homotypic signaling lymphocyte activation molecule (SLAM) receptor-ligand cell surface interactions between myeloid and lymphoid cells regulate innate adaptive immune responses. In this article, we report that SLAMF1 is indispensable for host resistance to primary vaccine-induced protection against fungal infection. Because vaccine immunity dependent on cell-mediated immunity, investigated the development of Ag-specific T cells. We studied cell-intrinsic -extrinsic role SLAMF1. generated...
Host genetic determinants that underpin variation in susceptibility to systemic fungal infection are poorly understood. Genes responsible for complex traits can be identified by correlating phenotype with allele founder strains of wild mice known variation, assembled reference panels. In this work, we describe wide natural both primary and acquired resistance experimental pulmonary blastomycosis eight strains, including 129, A/J, BL/6, CAST, NOD, NZO, PWK, WSB the Collaborative Cross...
ABSTRACT The development of effective vaccines against fungal infections requires the induction protective, pathogen-specific cell mediated immune responses. Here, we asked whether combination adjuvants based on delta inulin (Advax) formulated with TLR agonists could improve vaccine protection by a recombinant protein, Bl-Eng2, which itself harbors an immunodominant antigen and Dectin-2 agonist/adjuvant. We found that Bl-Eng2 Advax3 containing TLR9 agonist or Advax8, TLR4 agonist, provided...
<h3>Background</h3> Identification of neoepitopes/neoantigens represents a novel approach to cancer immunotherapy. In this study, we identified and characterized potential neoantigen peptides from lung adenocarcinoma patient tested their immunogenicity induce anti-tumor activity. <h3>Methods</h3> Six samples were examined. The tumor tissue the first was used for whole exome sequencing bulk RNA sequencing. Most candidate selected based on surface markers Ly9 (CD229), PLVAP, MBOAT7 non-surface...
ABSTRACT The development of safe subunit vaccines requires adjuvants that augment immunogenicity non-replicating protein-based antigens. Current against infectious diseases preferentially induce protective antibodies driven by such as alum. However, the contribution antibody to host defense is limited for certain classes fungi, whereas animal studies and clinical observations implicate cellular immunity an essential component resolution fungal pathogens. Here, we decipher structural bases a...
ABSTRACT Memory T cells underpin vaccine-induced immunity but are not yet fully understood. To distinguish features of memory that confer protective immunity, we used single cell transcriptome analysis to compare antigen-specific CD4 + recalled lungs mice received a or nonprotective subunit vaccine followed by challenge with fungal pathogen. We unexpectedly found populations specific protection expressed strong type I interferon response signature, whose distinctive transcriptional signature...
Abstract Using HER2-targeted antibody drug conjugates (ADC), we tested the therapeutic efficacy, direct impact on cancer stem cells (CSCs), and potential added benefit when combined with PD-L1 blockade in immunocompetent mouse tumor models. Two murine mammary models were used this study: D2F2/E2, a cell line resulting from stable transfection of parental D2F2 wild-type human HER2, 4T1-HER2, derived 4T1 by transduction HER2. We demonstrate that ADC treatment induced both cellular humoral...