A5010768212- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- T-cell and B-cell Immunology
- Plant Pathogens and Fungal Diseases
- Fungal and yeast genetics research
- Nail Diseases and Treatments
- Plant-Microbe Interactions and Immunity
- Infectious Diseases and Mycology
- Immunotherapy and Immune Responses
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Cutaneous lymphoproliferative disorders research
- Yeasts and Rust Fungi Studies
- IL-33, ST2, and ILC Pathways
- Transgenic Plants and Applications
- Pediatric health and respiratory diseases
- Parasitic Infections and Diagnostics
- Immune responses and vaccinations
- Allergic Rhinitis and Sensitization
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Studies on Chitinases and Chitosanases
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Mycobacterium research and diagnosis
- Hepatitis Viruses Studies and Epidemiology
University of Wisconsin–Madison
2016-2025
Massachusetts General Hospital
2023
UW Health University Hospital
2003-2020
Pediatrics and Genetics
2000-2017
University of Aberdeen
2015
Comprehensive Blood & Cancer Center
2007-2008
Bipar
2000-2006
University of Cincinnati Medical Center
1995
Wisconsin Division of Public Health
1985-1994
William S. Middleton Memorial Veterans Hospital
1994
In investigating six cases of blastomycosis in two school groups that had separately visited an environmental camp northern Wisconsin June 1984, we identified a large outbreak the disease and isolated Blastomyces dermatitidis from soil at beaver pond near camp. Of 89 elementary-school children 10 adults groups, 48 (51 percent) 95 evaluated September blastomycosis. cases, 26 (54 were symptomatic (the median incubation period was 45 days; range, 21 to 106 days). No weeks before or after these...
Microbial pathogens that normally inhabit our environment can adapt to thrive inside mammalian hosts. There are six dimorphic fungi cause disease worldwide, which switch from nonpathogenic molds in soil pathogenic yeast after spores inhaled and exposed elevated temperature. Mechanisms regulate this remain obscure. We show a hybrid histidine kinase senses host signals triggers the transition mold yeast. The also regulates cell-wall integrity, sporulation, expression of virulence genes vivo....
All human γδ T cells coexpressing the products of variable (V) region cell receptor (TCR) gene segments V γ 9 and δ 2 recognize antigens from some mycobacterial extracts Daudi cells. Exogenous endogenous ligands on surface, homologous to groEL heat shock family, induced reactivities that resembled superantigen responses in this major subset peripheral blood Stimulation 9/V is not restricted by leukocyte (HLA), including nonpolymorphic β -microglobulin (β M)-associated class Ib molecules....
Finding a role for PNECs in asthma Pulmonary neuroendocrine cells (PNECs) are rare cell type located airway and alveolar epithelia often contact with sensory nerve fibers. They have wide phylogenic distribution found even the relatively primitive lungs of amphibia reptiles, suggesting critical function. Sui et al. that mice lacking suppressed 2 (allergic) immune responses. were observed close proximity to group innate lymphoid (ILC2s) around branch points. The enhanced ILC2 activity by...
To determine whether simple protective isolation reduces the incidence of nosocomial bacterial and fungal infection during pediatric intensive care, we randomly assigned 70 children who were not immunosuppressed required mechanical ventilator support three or more days care to receive standard (n = 38) 32) with use disposable, nonwoven, polypropylene gowns nonsterile latex gloves. Risk factors predisposing patients comparable in two groups. Nosocomial colonization occurred later among...
Blastomycosis cannot yet be prevented or controlled, in part because the natural habitat of causative fungus, Blastomyces dermatitidis, remains ill defined. In investigating 2 outbreaks blastomycosis that occurred summer 1985 among persons engaged activities along rivers contiguous central Wisconsin counties, we isolated B. dermatitidis from soil at one riverbanks. developed 7 (58%) 12 residents and guests who has gathered a pheasant farm on Tomorrow River early May, (88%) 8 boys 1 adult had...
The Fenton-chemistry-generating properties of copper ions are considered a potent phagolysosome defense against pathogenic microbes, yet our understanding underlying host/microbe dynamics remains unclear. We address this issue in invasive aspergillosis and demonstrate that host fungal responses inextricably connect reactive oxygen intermediate (ROI) mechanisms. Loss the copper-binding transcription factor AceA yields an Aspergillus fumigatus strain displaying increased sensitivity to ROI...
Millions of hibernating bats across North America have died from white-nose syndrome (WNS), an emerging disease caused by a psychrophilic (cold-loving) fungus,
Systemic fungal infections with primary and opportunistic pathogens have become increasingly common represent a growing health menace in patients AIDS other immune deficiencies. T lymphocyte immunity, particular the CD4+ Th 1 cells, is considered main defense against these pathogens, their absence associated increased susceptibility. It would seem illogical then to propose vaccinating vulnerable infections. We report here that cells are dispensable for vaccine-induced resistance experimental...
Systemic fungal infections are becoming more common and difficult to treat, yet the pathogenesis of these infectious diseases remains poorly understood. In many cases, pathogenicity can be attributed ability fungi adhere target tissues, but lack tractable genetic systems has limited progress in understanding interfering with offending products. Blastomyces dermatitidis, agent blastomycosis, a respiratory disseminated mycosis people animals worldwide, expression putative adhesin encoded by...
Recent studies of the dimorphic fungal pathogens Histoplasma capsulatum and Paracoccidioides brasiliensis have suggested a role in virulence for cell surface carbohydrate alpha-(1,3)-glucan. To investigate possible basis alpha-(1,3)-glucan pathogenicity fungus Blastomyces dermatitidis, we examined three genetically related strains B. dermatitidis that differ their mice: wild-type virulent strain ATCC 26199; mutant 60915, which is 10,000-fold reduced virulence; 60916, avirulent. Immunologic...
Blastomyces dermatitidis, the etiologic agent of blastomycosis, causes severe disease and substantial mortality in those immunocompromised by acquired immunodeficiency syndrome or malignancy. In solid organ transplant recipients, epidemiology, clinical features, outcomes have not been fully described.We conducted a retrospective case-series at University Wisconsin Hospital Clinics. Case patients were recipients with blastomycosis.From 1986 to 2004, we identified 11 cases post-transplant...
Three genetically related strains of Blastomyces dermatitidis (Bd) yeasts that differ in their expression WI-1, an immunodominant cell wall Ag, were tested for capacity to bind human macrophages (M phi) the absence serum. These included American Type Culture Collection (ATCC, Rockville, MD) ATCC 26199, which is virulent mice; attenuated mutant strain 60915, expresses 2.5-fold more WI-1 than 26199; and avirulent strain, 60916, has sixfold 26199. Attachment both M phi was rapid maximum after...