A5066271045- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Graphene and Nanomaterials Applications
- Porphyrin and Phthalocyanine Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organic Light-Emitting Diodes Research
- Supramolecular Self-Assembly in Materials
- Photoacoustic and Ultrasonic Imaging
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Polydiacetylene-based materials and applications
- Dendrimers and Hyperbranched Polymers
- Radiation Therapy and Dosimetry
- Synthesis and Properties of Aromatic Compounds
- interferon and immune responses
- Space Satellite Systems and Control
- Orbital Angular Momentum in Optics
- Boron Compounds in Chemistry
- Carbon and Quantum Dots Applications
Soochow University
2014-2024
Nanyang Technological University
2018-2023
Suzhou Research Institute
2015
Abstract Herein, an intelligent biodegradable hollow manganese dioxide (H-MnO 2 ) nano-platform is developed for not only tumor microenvironment (TME)-specific imaging and on-demand drug release, but also modulation of hypoxic TME to enhance cancer therapy, resulting in comprehensive effects favoring anti-tumor immune responses. With structures, H-MnO nanoshells post modification with polyethylene glycol (PEG) could be co-loaded a photodynamic agent chlorine e6 (Ce6), chemotherapy...
Hypoxia of solid tumor compromises the therapeutic outcome photodynamic therapy (PDT) that relies on localized O2 molecules to produce highly cytotoxic singlet oxygen (1O2) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting ruthenium as active catalytic site anchored in metal-organic framework Mn3[Co(CN)6]2 with encapsulated chlorin e6 (Ce6), which serves catalase-like nanozyme for generation....
Multifunctional nanoplatforms that are safe and have multiple therapeutic functions together with imaging capabilities highly demanded in the development of new cancer theranostic approaches. A number near-infrared (NIR)-absorbing inorganic nanomaterials, although having shown great promise not only to photothermally ablate tumors but also enhance efficacy other types therapies, biodegradable would be retained body for a long time. Herein, we develop multifunctional nanocomposite by coating...
Photodynamic therapy (PDT) is an oxygen-dependent light-triggered noninvasive therapeutic method showing many promising aspects in cancer treatment. For effective PDT, nanoscale carriers are often needed to realize tumor-targeted delivery of photosensitizers, which ideally should further target specific cell organelles that most vulnerable reactive oxygen species (ROS). Second, as critical for PDT-induced destruction, overcoming hypoxia existing the majority solid tumors important optimizing...
Photodynamic therapy (PDT) as a treatment method has many advantages such minimal invasiveness, repeatable dosage, and low systemic toxicity. Issues with conventional PDT agents include the limited availability of endogenous oxygen difficulty in accumulation at tumor site, which hindered successful tumors. Herein, we developed catalase-encapsulated hyaluronic-acid-based nanoparticles loaded adamantane-modified photosensitizer for enhanced solid Chlorin e6 (Ce6) was modified adamantane to...
Photodynamic therapy (PDT) is considered as a safe and selective way to treat wide range of cancers well nononcological disorders. However, oxygen required in the process PDT, hypoxic tumor microenvironment has largely limited efficacy PDT tumors especially those with relatively large sizes. To this end, we uncover that hyaluronidase (HAase), which breaks down hyaluronan, major component extracellular matrix (ECM) tumors, would be able enhance nanoparticle-based for vivo cancer treatment. It...
Uncontrolled cancer cell proliferation, insufficient blood flow, and inadequate endogenous oxygen lead to hypoxia in tumor tissues. Herein, a unique type of hypoxia-responsive human serum albumin (HSA)-based nanosystem (HCHOA) is reported, prepared by cross-linking the hypoxia-sensitive azobenzene group between photosensitizer chlorin e6 (Ce6)-conjugated HSA (HC) oxaliplatin prodrug-conjugated (HO). The HCHOA stable under normal partial pressure with size 100-150 nm. When exposed hypoxic...
Red blood cells are attached to iron oxide nanoparticles pre-coated with chlorine e6, a photosensitizer, and then loaded chemotherapeutic drug, doxorubicin, enable imaging-guided combined photodynamic chemotherapy of cancer, achieving excellent synergistic therapeutic effects in an animal tumor model. This work highlights the great promise integrating cell-based drug-delivery systems nanotechnology as biocompatible multifunctional platform for applications cancer theranostics. As service our...
With the increasing interests of using graphene and its derivatives in area biomedicine, systematic evaluation their potential risks impacts to biological systems is becoming critically important. In this work, we carefully study how surface coatings affect cytotoxicity extracellular biodegradation behaviors oxide (GO) derivatives. Although naked GO could induce significant toxicity macrophages, coating those two‐dimensional nanomaterials with biocompatible macromolecules such as...
While manipulating the helicity of nanostructures is a challenging task, it attracts great research interest on account its crucial role in better understanding formation mechanisms helical systems. For supramolecular chirality self-assembly systems, one challenge how to understand origin and inherent information regulated by functionality-oriented stacking modes (such as J- H-aggregation) building blocks. Herein, two-component hydrogels were prepared phenylalanine-based enantiomers achiral...
Abstract Development of novel strategies for achieving amorphous ultralong organic phosphorescence (UOP) at room temperature is highly desired. Herein, a simple approach reported by coassembling small molecules with polyvinyl alcohol (PVA) to afford UOP. These planar conformation present quenched triplet state emission in an excessive stacking solid state. When these PVA, their structures are well confined coassembly films. Such environment leads restricted molecular rotation and vibration,...
Developing molecules with high emission efficiency both in solution and the solid state is still a great challenge, since most organic luminogens are either aggregation-caused quenching or aggregation-induced molecules. This dilemma was overcome by integrating planar distorted structures long alkyl side chains to achieve DAπAD type emitters. A linear diphenyl-diacetylene core charge transfer effect ensure considerable planarity of these excited state, allowing strong dilute (quantum yield up...
Abstract Reactive oxygen species (ROS) plays a critical role in tissue repair, including bone. Therefore, detecting and regulating ROS is essential for monitoring facilitating bone repair. In this study, the first time, spatiotemporal profile of ROS, represented by hydrogen peroxide (H 2 O ), injury microenvironment using photoacoustic imaging technique visualized. The levels significantly increase upon injury, peak at certain stage healing, then gradually decrease toward baseline level. To...
Radiotherapy (RT), as one of the main methods in clinical treatment various malignant tumors, would induce systemic immunotherapeutic effects by triggering immunogenic cell death (ICD) cancer cells. However, antitumor immune responses produced RT-induced ICD alone usually are not robust enough to eliminate distant tumors and thus ineffective against metastases. Herein, a biomimetic mineralization method for facile synthesis MnO2 nanoparticles with high anti-programmed ligand 1 (αPDL1)...
Abstract Radiotherapy (RT) is an extensively used strategy for cancer treatment, but its therapeutic effect usually limited by the abnormal tumor microenvironment (TME) and it lacks ability to control metastases. In this work, a nanoscale coordination polymer, Hf‐nIm@PEG (HNP), prepared of hafnium ions (Hf 4+ ) with 2‐nitroimidazole (2‐nIm), then modified lipid bilayers containing poly(ethylene glycol) (PEG). Under low‐dose X‐ray irradiation, on one hand, Hf high computed tomography signal...
Smart drug delivery systems with on‐demand release capability are rather attractive to realize highly specific cancer treatment. Herein, a novel light‐responsive platform based on photosensitizer chlorin e6 (Ce6) doped mesoporous silica nanorods (CMSNRs) is developed for light‐triggered release. In this design, CMSNRs coated bovine serum albumin (BSA) via singlet oxygen (SO)‐sensitive bis‐(alkylthio)alkene (BATA) linker, and then modified polyethylene glycol (PEG). The obtained...
Upconversion nanoparticles (UCNPs) have drawn much attention in cancer imaging and therapy recent years. Herein, we for the first time report use of UCNPs with carefully engineered surface chemistry combined photodynamic (PDT) gene cancer. In our system, positively charged NaGdF4:Yb,Er multilayered polymer coatings are synthesized via a layer by strategy, then loaded simultaneously Chlorin e6 (Ce6), photosensitizing molecule, small interfering RNA (siRNA), which targets Plk1 oncogene. On one...
Abstract Recently, the development of multifunctional theranostic nanoplatforms to realize tumor‐specific imaging and enhanced cancer therapy via responding or modulating tumor microenvironment (TME) has attracted tremendous interests in field nanomedicine. Herein, tungsten disulfide (WS 2 ) nanoflakes with their surface adsorbed iron oxide nanoparticles (IONPs) self‐assembly are coated silica then subsequently manganese dioxide (MnO ), on which polyethylene glycol (PEG) is attached. The...
Precise control over helical chirality and dimensions of molecular self-assemblies, a remaining challenge for both chemists materials scientists, is the key to manipulate property performance supramolecular materials. Herein, we report that cholesterol-azopyridine conjugate could self-assemble into organogels with photocontrollable dimensional transition from 2D microbelts 1D nanotubes finally 0D nanoparticles. The E/ Z-Photoisomerization 4-azopyridine unit major driving force...